Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

by Mahajan A., SIM XUELING, Ng H.J., Manning A., Rivas M.A., Highland H.M., Locke A.E., Grarup N., Im H.K., Cingolani P., Flannick J., Fontanillas P., Fuchsberger C., Gaulton K.J., Teslovich T.M., Rayner N.W., Robertson N.R., Beer N.L., Rundle J.K., Bork-Jensen J., Ladenvall C., Blancher C., Buck D., Buck G., Burtt N.P., Gabriel S., Gjesing A.P., Groves C.J., Hollensted M., Huyghe J.R., Jackson A.U., Jun G., Justesen J.M., Mangino M., Murphy J., Neville M., Onofrio R., Small K.S., Stringham H.M., Syvänen A.-C., Trakalo J., Abecasis G., Bell G.I., Blangero J., Cox N.J., Duggirala R., Hanis C.L., Seielstad M., Wilson J.G., Christensen C., Brandslund I., Rauramaa R., Surdulescu G.L., Doney A.S.F., Lannfelt L., Linneberg A., Isomaa B., Tuomi T., Jørgensen M.E., Jørgensen T., Kuusisto J., Uusitupa M., Salomaa V., Spector T.D., Morris A.D., Palmer C.N.A., Collins F.S., Mohlke K.L., Bergman R.N., Ingelsson E., Lind L., Tuomilehto J., Hansen T., Watanabe R.M., Prokopenko I., Dupuis J., Karpe F., Groop L., Laakso M., Pedersen O., Florez J.C., Morris A.P., Altshuler D., Meigs J.B., Boehnke M., McCarthy M.I., Lindgren C.M., Gloyn A.L., Abboud H.E., Afzal U., Aguilar D., Arya R., Atzmon G., Aung T., Banks E., Barroso I., Barzilai N., Below J.E., Bharadwaj D., Blackwell T.W., Bonnycastle L.L., Bowden D., Carey J., Carneiro M.O., Chambers J.C., Chan E., Chan J., Chandak G.R., Chen P., Chen Y., Chen H., Cheng C.-Y., Chia K.S., Cho Y.S., Correa A., Curran J.E., Daly M.J., Day-Williams A.G., DeFronzo R.A., DePristo M., Donnelly P.J., Ebrahim S.B., Elliott P., Esko T., Fadista J., Farjoun Y., Farmer A.J., Farook V.S., Fennell T., Ferreira T., Fingerlin T., Forsén T., Fowler S.P., Franks P.W., Frayling T.M., Freedman B.I., Froguel P., Gamazon E.R., Gieger C., Glaser B., Go M.J., Goldstein J.I., Grallert H., Grant G., Green T., Griswold M., Hale D.E., Han B.-G., Hartl C., Hattersley A.T., Hicks P.J., Hodgkiss D., Horikoshi M., Hrabé de Angelis M., Hu C., Hu F.B., Huh I., Kamran Ikram M., Illig T., Jablonski K.A., Jenkinson C.P., Jia W., Kang H.M., Khor C.-C., Kim Y., Kim Y.J., Kim B.-J., Kinnunen L., Kooner J.S., Kravic J., Kriebel J., Kumar A., Kumar S., Kuulasmaa T., Kwon M.-S., Langenberg C., Lauritzen T., Lee S., Lee J., Lee J., Lee J.-Y., Lehman D.M., Lehne B., Levy J.C., Li J., Liang L., Lim W.Y., Lin K.-H., Liu J., Loh M., Ma R.C.W., Ma C., Mägi R., Maguire J., Maxwell T.J., McVean G., Meisinger C., Meitinger T., Melander O., Metspalu A., Mihailov E., Milani L., Moutsianas L., Müller-Nurasyid M., K. Musani S., Nagai Y., Narisu N., Neale B.M., Ng M.C.Y., Nilsson P., O'Rahilly S.P., Orho-Melander M., Owen K.R., Palmer N.D., Park T., Pasko D., Pearson R.D., Perry J.R.B., Peters A., Pollin T.I., Poplin R., Prabhakaran D., Puppala S., Purcell S., Qi L., Qi Q., Roden M., Rolandsson O., Rosengren A.H., Sandhu M., Schwarzmayr T., Scott L.J., Scott R.A., Scott J., Scott W.R., Sehmi J., Shakir K., Sladek R., Smith J.D., Stancáková A., Strauch K., Strom T.M., Swift A., Tai E.S., Tajes J.F., Tan S.-T., Tandon N., Taylor H.A., Jr., Teo Y.Y., Thameem F., Thorand B., van de Bunt M., Varga T.V., Walker M., Wareham N.J., Welch R.P., Wieland T., Wilson G., Sr., Wong T.Y., Wood A.R., Yoon J., Zeggini E., Zhang W.
Published 2018

A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

by Manning, A, Highland, HM, Gasser, J, Sim, X, Tukiainen, T, Fontanillas, P, Grarup, N, Rivas, MA, Mahajan, A, Locke, AE, Cingolani, P, Pers, TH, Viñuela, A, Brown, AA, Wu, Y, Flannick, J, Fuchsberger, C, Gamazon, ER, Gaulton, KJ, Im, HK, Teslovich, TM, Blackwell, TW, Bork-Jensen, J, Burtt, NP, Chen, Y, Green, T, Hartl, C, Kang, HM, Kumar, A, Ladenvall, C, Ma, C, Moutsianas, L, Pearson, RD, Perry, JRB, Rayner, NW, Robertson, NR, Scott, LJ, van de Bunt, M, Eriksson, JG, Jula, A, Koskinen, S, Lehtimäki, T, Palotie, A, Raitakari, OT, Jacobs, SB, Wessel, J, Chu, AY, Scott, RA, Goodarzi, MO, Blancher, C, Buck, G, Buck, D, Chines, PS, Gabriel, S, Gjesing, AP, Groves, CJ, Hollensted, M, Huyghe, JR, Jackson, AU, Jun, G, Justesen, JM, Mangino, M, Murphy, J, Neville, M, Onofrio, R, Small, KS, Stringham, HM, Trakalo, J, Banks, E, Carey, J, Carneiro, MO, DePristo, M, Farjoun, Y, Fennell, T, Goldstein, JI, Grant, G, Hrabé de Angelis, M, Maguire, J, Neale, BM, Poplin, R, Purcell, S, Schwarzmayr, T, Shakir, K, Smith, JD, Strom, TM, Wieland, T, Lindstrom, J, Brandslund, I, Christensen, C, Surdulescu, GL, Lakka, TA, Doney, ASF, Nilsson, P, Wareham, NJ, Langenberg, C, Varga, TV, Franks, PW, Rolandsson, O, Rosengren, AH, Farook, VS, Thameem, F, Puppala, S, Kumar, S, Lehman, DM, Jenkinson, CP, Curran, JE, Hale, DE, Fowler, SP, Arya, R, DeFronzo, RA, Abboud, HE, Syvänen, A-C, Hicks, PJ, Palmer, ND, Ng, MCY, Bowden, DW, Freedman, BI, Esko, T, Mägi, R, Milani, L, Mihailov, E, Metspalu, A, Narisu, N, Kinnunen, L, Bonnycastle, LL, Swift, A, Pasko, D, Wood, AR, Fadista, J, Pollin, TI, Barzilai, N, Atzmon, G, Glaser, B, Thorand, B, Strauch, K, Peters, A, Roden, M, Müller-Nurasyid, M, Liang, L, Kriebel, J, Illig, T, Grallert, H, Gieger, C, Meisinger, C, Lannfelt, L, Musani, SK, Griswold, M, Taylor, HA, Wilson, G, Correa, A, Oksa, H, Scott, WR, Afzal, U, Tan, S-T, Loh, M, Chambers, JC, Sehmi, J, Kooner, JS, Lehne, B, Cho, YS, Lee, J-Y, Han, B-G, Käräjämäki, A, Qi, Q, Qi, L, Huang, J, Hu, FB, Melander, O, Orho-Melander, M, Below, JE, Aguilar, D, Wong, TY, Liu, J, Khor, C-C, Chia, KS, Lim, WY, Cheng, C-Y, Chan, E, Tai, ES, Aung, T, Linneberg, A, Isomaa, B, Meitinger, T, Tuomi, T, Hakaste, L, Kravic, J, Jørgensen, ME, Lauritzen, T, Deloukas, P, Stirrups, KE, Owen, KR, Farmer, AJ, Frayling, TM, O'Rahilly, SP, Walker, M, Levy, JC, Hodgkiss, D, Hattersley, AT, Kuulasmaa, T, Stančáková, A, Barroso, I, Bharadwaj, D, Chan, J, Chandak, GR, Daly, MJ, Donnelly, PJ, Ebrahim, SB, Elliott, P, Fingerlin, T, Froguel, P, Hu, C, Jia, W, Ma, RCW, McVean, G, Park, T, Prabhakaran, D, Sandhu, M, Scott, J, Sladek, R, Tandon, N, Teo, YY, Zeggini, E, Watanabe, RM, Koistinen, HA, Kesaniemi, YA, Uusitupa, M, Spector, TD, Salomaa, V, Rauramaa, R, Palmer, CNA, Prokopenko, I, Morris, AD, Bergman, RN, Collins, FS, Lind, L, Ingelsson, E, Tuomilehto, J, Karpe, F, Groop, L, Jørgensen, T, Hansen, T, Pedersen, O, Kuusisto, J, Abecasis, G, Bell, GI, Blangero, J, Cox, NJ, Duggirala, R, Seielstad, M, Wilson, JG, Dupuis, J, Ripatti, S, Hanis, CL, Florez, JC, Mohlke, KL, Meigs, JB, Laakso, M, Morris, AP, Boehnke, M, Altshuler, D, McCarthy, MI, Gloyn, AL, Lindgren, CM
Published 2017