The relationship between retinal arteriolar and venular calibers is genetically mediated, and each is associated with risk of cardiovascular disease

by Fahy, S.J., Sun, C., Zhu, G., Healey, P.R., Spector, T.D., Martin, N.G., Mitchell, P., Wong, T.Y., Mackey, D.A., Hammond, C.J., Andrew, T.
Published 2014

NOVEL SUSCEPTABILITY LOCI FOR OSTEOARTHRITIS OF THE HAND: CODING VARIANTS IN MGP AND ENPP3

by Hollander, W. den, Boer, C.G., Hart, D., Yau, M.S., Ramos, Y.F., Metrustry, S., Broer, L., Deelen, J., Beekman, M., Cupples, L.A., Rivadeneira, F., Kloppenburg, M., Peters, M., Spector, T.D., Hofman, A., Slagboom, P.E., Nelissen, R.G., Uitterlinden, A.G., Felson, D.T., Valdes, A., Meulenbelt, I., Meurs, J.J. van
Published 2016

Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

by Williams, F.M.K., Bansal, A.T., Meurs, J.B. van, Bell, J.T., Meulenbelt, I., Suri, P., Rivadeneira, F., Sambrook, P.N., Hofman, A., Bierma-Zeinstra, S., Menni, C., Kloppenburg, M., Slagboom, P.E., Hunter, D.J., MacGregor, A.J., Uitterlinden, A.G., Spector, T.D.
Published 2013

LARGE SCALE META-ANALYSIS OF INTERLEUKIN-1 BETA AND INTERLEUKIN-1 RECEPTOR ANTAGONIST POLYMORPHISMS ON RISK OF RADIOGRAPHIC HIP AND KNEE OSTEOARTHRITIS AND SEVERITY OF KNEE OSTEOAR...

by Kerkhof, H.J., Doherty, M., Abramson, S.B., Arden, N.K., Attur, M., Bos, S., Cooper, C., Doherty, S.A., Evangelou, E., Kerna, I., Kisand, K., Kloppenburg, M., Maciewicz, R.A., Meulenbelt, I., Sezgin, M., Slagboom, E., Smith, A., Spector, T.D., Tamm, A., Uitterlinden, A.G., Wheeler, M., Zhang, W., Meurs, J.B. van, Valdes, A.M.
Published 2010

IRF4 Variants Have Age-Specific Effects on Nevus Count and Predispose to Melanoma

by Duffy, D.L., Iles, M.M., Glass, D., Zhu, G., Barrett, J.H., Hoiom, V., Zhao, Z.Z., Sturm, R.A., Soranzo, N., Hammond, C., Kvaskoff, M., Whiteman, D.C., Mangino, M., Hansson, J., Newton-Bishop, J.A., Bataille, V., Hayward, N.K., Martin, N.G., Bishop, D.T., Spector, T.D., Montgomery, G.W., GenoMEL
Published 2010

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

by Hollander, W. den, Boer, C.G., Hart, D.J., Yau, M.S., Ramos, Y.F.M., Metrustry, S., Broer, L., Deelen, J., Cupples, L.A., Rivadeneira, F., Kloppenburg, M., Peters, M., Spector, T.D., Hofman, A., Slagboom, P.E., Nelissen, R.G.H.H., Uitterlinden, A.G., Felson, D.T., Valdes, A.M., Meulenbelt, I., Meurs, J.J.B. van
Published 2017

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

by Hollander, W. den, Boer, C.G., Hart, D.J., Yau, M.S., Ramos, Y.F.M., Metrustry, S., Broer, L., Deelen, J., Cupples, L.A., Rivadeneira, F., Kloppenburg, M., Peters, M., Spector, T.D., Hofman, A., Slagboom, P.E., Nelissen, R.G.H.H., Uitterlinden, A.G., Felson, D.T., Valdes, A.M., Meulenbelt, I., Meurs, J.J.B. van
Published 2017

The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome- wide statistical significance in males

by Evangelou, E., Valdes, A.M., Castano-Betancourt, M.C., Doherty, M., Doherty, S., Esko, T., Ingvarsson, T., Ioannidis, J.P.A., Kloppenburg, M., Metspalu, A., Ntzani, E.E., Panoutsopoulou, K., Slagboom, P.E., Southam, L., Spector, T.D., Styrkarsdottir, U., Stefanson, K., Uitterlinden, A.G., Wheeler, M., Zeggini, E., Meulenbelt, I., Meurs, J.B. van, ArcOGEN Consortium, TREAT-OA Consortium
Published 2013

Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, i...

by Valdes, A.M., Meulenbelt, I., Chassaing, E., Arden, N.K., Bierma-Zeinstra, S., Harat, D., Hofman, A., Karsdal, M., Kloppenburg, M., Kroon, H.M., Slagboom, E.P., Spector, T.D., Uitterlinden, A.G., Meurs, J.B. van, Bay-Jensen, A.C.
Published 2014

Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance

by Ramos, Y.F.M., Metrustry, S., Arden, N., Bay-Jensen, A.C., Beekman, M., Craen, A.J.M. de, Cupples, L.A., Esko, T., Evangelou, E., Felson, D.T., Hart, D.J., Ioannidis, J.P.A., Karsdal, M., Kloppenburg, M., Lafeber, F., Metspalu, A., Panoutsopoulou, K., Slagboom, P.E., Spector, T.D., Spil, E.W.E. van, Uitterlinden, A.G., Zhu, Y.Y., Valdes, A.M., Meurs, J.B.J. van, Meulenbelt, I., arcOGEN Consortium, TreatOA Collaborators
Published 2014

Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study

by Liu Y.-Z., Wilson S.G., Wang L., Liu X.-G., Guo Y.-F., Li J., Yan H., Deloukas P., Soranzo N., Chinnapen-Horsley U., Cervino A., Williams F.M., Xiong D.-H., Zhang Y.-P., Jin T.-B., Levy S., Papasian C.J., Drees B.M., Hamilton J.J., Recker R.R., Spector T.D., Deng H.-W.
Published 2019

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

by Deelen, J., Kettunen, J., Fischer, K., Spek, A. van der, Trompet, S., Kastenmuller, G., Boyd, A., Zierer, J., Akker, E.B. van den, Ala-Korpela, M., Amin, N., Demirkan, A., Ghanbari, M., Heemst, D. van, Ikram, M.A., Klinken, J.B. van, Mooijaart, S.P., Peters, A., Salomaa, V., Sattar, N., Spector, T.D., Tiemeier, H., Verhoeven, A., Waldenberger, M., Wurtz, P., Smith, G.D., Metspalu, A., Perola, M., Menni, C., Geleijnse, J.M., Drenos, F., Beekman, M., Jukema, J.W., Duijn, C.M. van, Slagboom, P.E.
Published 2019

IgG glycosylation and DNA methylation are interconnected with smoking

by Wahl, A., Kasela, S., Carnero-Montoro, E., Iterson, M. van, Stambuk, J., Sharma, S., Akker, E. van den, Klaric, L., Benedetti, E., Razdorov, G., Trbojevic-Akmacic, I., Vuckovic, F., Ugrina, I., Beekman, M., Deelen, J., Heemst, D. van, Heijmans, B.T., Wuhrer, M., Plomp, R., Keser, T., Simurina, M., Pavic, T., Gudelj, I., Kristic, J., Grallert, H., Kunze, S., Peters, A., Bell, J.T., Spector, T.D., Milani, L., Slagboom, P.E., Lauc, G., Gieger, C., B I O S Consortium
Published 2018

Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

by Broer, L., Codd, V., Nyholt, D.R., Deelen, J., Mangino, M., Willemsen, G., Albrecht, E., Amin, N., Beekman, M., Geus, E.J.C. de, Henders, A., Nelson, C.P., Steves, C.J., Wright, M.J., Craen, A.J.M. de, Isaacs, A., Matthews, M., Moayyeri, A., Montgomery, G.W., Oostra, B.A., Vink, J.M., Spector, T.D., Slagboom, P.E., Martin, N.G., Samani, N.J., Duijn, C.M. van, Boomsma, D.I.
Published 2013

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

by Broer, L., Raschenberger, J., Deelen, J., Mangino, M., Codd, V., Pietilainen, K.H., Albrecht, E., Amin, N., Beekman, M., Craen, A.J.M. de, Gieger, C., Haun, M., Henneman, P., Herder, C., Hovatta, I., Laser, A., Kedenko, L., Koenig, W., Kollerits, B., Moilanen, E., Oostra, B.A., Paulweber, B., Quaye, L., Rissanen, A., Roden, M., Surakka, I., Valdes, A.M., Vuolteenaho, K., Thorand, B., Dijk, K.W. van, Kaprio, J., Spector, T.D., Slagboom, P.E., Samani, N.J., Kronenberg, F., Duijn, C.M. van, Ladwig, K.H.
Published 2014

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis

by Castano-Betancourt, M.C., Evans, D.S., Ramos, Y.F.M., Boer, C.G., Metrustry, S., Liu, Y.F., Hollander, W. den, Rooij, J. van, Kraus, V.B., Yau, M.S., Mitchell, B.D., Muir, K., Hofman, A., Doherty, M., Doherty, S., Zhang, W.Y., Kraaij, R., Rivadeneira, F., Barrett-Connor, E., Maciewicz, R.A., Arden, N., Nelissen, R.G.H.H., Kloppenburg, M., Jordan, J.M., Nevitt, M.C., Slagboom, E.P., Hart, D.J., Lafeber, F., Styrkarsdottir, U., Zeggini, E., Evangelou, E., Spector, T.D., Uitterlinden, A.G., Lane, N.E., Meulenbelt, I., Valdes, A.M., Meurs, J.B.J. van
Published 2016

EPHA2 is associated with age-related cortical cataract in mice and humans

by Jun G., Guo H., Klein B.E.K., Klein R., Jie J.W., Mitchell P., Miao H., Lee K.E., Joshi T., Buck M., Chugha P., Bardenstein D., Klein A.P., Bailey-Wilson J.E., Gong X., Spector T.D., Andrew T., Hammond C.J., Elston R.C., Iyengar S.K., Wang B.
Published 2019

A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14

by Solouki, A.M., Verhoeven, V.J.M., Duijn, C.M. van, Verkerk, A.J.M.H., Ikram, M.K., Hysi, P.G., Despriet, D.D.G., Koolwijk, L.M. van, Ho, L., Ramdas, W.D., Czudowska, M., Kuijpers, R.W.A.M., Amin, N., Struchalin, M., Aulchenko, Y.S., Rij, G. van, Riemslag, F.C.C., Young, T.L., Mackey, D.A., Spector, T.D., Gorgels, T.G.M.F., Willemse-Assink, J.J.M., Isaacs, A., Kramer, R., Swagemakers, S.M.A., Bergen, A.A.B., Oosterhout, A.A.L.J. van, Oostra, B.A., Rivadeneira, F., Uitterlinden, A.G., Hofman, A., Jong, P.T.V.M. de, Hammond, C.J., Vingerling, J.R., Klaver, C.C.W.
Published 2010

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

by Spek, A. van der, Broer, L., Draisma, H.H.M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D.R., Dharuri, H.K., Codd, V., Amin, N., Geus, E.J.C. de, Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A.K., Isaacs, A., Medland, S.E., Montgomery, G.W., Mooijaart, S.P., Strauch, K., Suchiman, H.E.D., Vaarhorst, A.A.M., Heemst, D. van, Wang-Sattler, R., Whitfield, J.B., Willemsen, G., Wright, M.J., Martin, N.G., Samani, N.J., Metspalu, A., Slagboom, P.E., Spector, T.D., Boomsma, D.I., Duijn, C.M. van, Gieger, C.
Published 2019

A genome-wide association study of early menopause and the combined impact of identified variants

by Perry, J.R.B., Corre, T., Esko, T., Chasman, D.I., Fischer, K., Franceschini, N., He, C., Kutalik, Z., Mangino, M., Rose, L.M., Vernon smith, A., Stolk, L., Sulem, P., Weedon, M.N., Zhuang, W.V., Arnold, A., Ashworth, A., Bergmann, S., Buring, J.E., Burri, A., Chen, C., Cornelis, M.C., Couper, D.J., Goodarzi, M.O., Gudnason, V., Harris, T., Hofman, A., Jones, M., Kraft, P., Launer, L., Laven, J.S.E., Li, G., Mcknight, B., Masciullo, C., Milani, L., Orr, N., Psaty, B.M., Ridker, P.M., Rivadeneira, F., Sala, C., Salumets, A., Schoemaker, M., Traglia, M., Waeber, G., Chanock, S.J., Demerath, E.W., Garcia, M., Hankinson, S.E., Hu, F.B., Hunter, D.J., Lunetta, K.L., Metspalu, A., Montgomery, G.W., Murabito, J.M., Newman, A.B., Ong, K.K., Spector, T.D., Stefansson, K., Swerdlow, A.J., Thorsteinsdottir, U., Van dam, R.M., Uitterlinden, A.G., Visser, J.A., Vollenweider, P., Toniolo, D., Murray, A.
Published 2014