Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice—An Animal Model of CLN10 Disease

by Mahmoud Bassal, Junling Liu, Wanda Jankowiak, Paul Saftig, Udo Bartsch
Published 2021-03-01

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice

by Julia Kobuch, Haissi Cui, Barbara Grünwald, Paul Saftig, Percy A. Knolle, Achim Krüger
Published 2015-08-01

Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function

by Tobias Huth, Karoline Schmidt-Neuenfeldt, Andrea Rittger, Paul Saftig, Karina Reiss, Christian Alzheimer
Published 2009-02-01

Adam10-dependent Notch signaling establishes dental epithelial cell boundaries required for enamel formation

by Thimios A. Mitsiadis, Lucia Jimenez-Rojo, Anamaria Balic, Silvio Weber, Paul Saftig, Pierfrancesco Pagella
Published 2022-10-01

Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.

by Hanna Appelqvist, Linnea Sandin, Karin Björnström, Paul Saftig, Brett Garner, Karin Ollinger, Katarina Kågedal
Published 2012-01-01

Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment

by Karen Caeyenberghs, Detlef Balschun, Diego Prieto Roces, Michael Schwake, Paul Saftig, Rudi D'Hooge
Published 2006-08-01

Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes

by Adriana Carolina Gonzalez, Michaela Schweizer, Sebastian Jagdmann, Christian Bernreuther, Thomas Reinheckel, Paul Saftig, Markus Damme
Published 2018-01-01

Intravitreal gene therapy restores the autophagy-lysosomal pathway and attenuates retinal degeneration in cathepsin D-deficient mice

by Junling Liu, Mahmoud Bassal, Stefanie Schlichting, Ingke Braren, Alessandro Di Spiezio, Paul Saftig, Udo Bartsch
Published 2022-03-01

Tetraspanin 15 depletion impairs extracellular vesicle docking at target neurons

by Daniele Stajano, Franco L. Lombino, Michaela Schweizer, Markus Glatzel, Paul Saftig, Kira V. Gromova, Matthias Kneussel
Published 2023-09-01

Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation

by Marion Willenborg, Christine Kathrin Schmidt, Peter Braun, Jobst Landgrebe, Kurt von Figura, Paul Saftig, Eeva-Liisa Eskelinen
Published 2005-12-01

Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes

by Ariane Schleinitz, Lara-Alina Pöttgen, Tal Keren-Kaplan, Jing Pu, Paul Saftig, Juan S. Bonifacino, Albert Haas, Andreas Jeschke
Published 2023-01-01

LAMP-2 Is Involved in Surface Expression of RANKL of Osteoblasts In Vitro

by Ineke D.C. Jansen, Wikky Tigchelaar-Gutter, Jolanda M. A. Hogervorst, Teun J. de Vries, Paul Saftig, Vincent Everts
Published 2020-08-01

Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice

by Stijn Stroobants, Markus Damme, Ann Van der Jeugd, Ben Vermaercke, Claes Andersson, Jens Fogh, Paul Saftig, Judith Blanz, Rudi D'Hooge
Published 2017-10-01

Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease

by Lisa Gallwitz, Lina Schmidt, André R.A. Marques, Andreas Tholey, Liam Cassidy, Irem Ulku, Gerhard Multhaup, Alessandro Di Spiezio, Paul Saftig
Published 2022-12-01

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

by Irem Ulku, Filip Liebsch, S. Can Akerman, Jana F. Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup
Published 2023-02-01

The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP

by David Massa López, Melanie Thelen, Felix Stahl, Christian Thiel, Arne Linhorst, Marc Sylvester, Irm Hermanns-Borgmeyer, Renate Lüllmann-Rauch, Winnie Eskild, Paul Saftig, Markus Damme
Published 2019-10-01

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

by Caitlin N. Suire, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Monica K. Brizuela, Paul Saftig, Dennis W. Dickson, Terrone L. Rosenberry, Malcolm A. Leissring
Published 2020-07-01

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

by Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel, Hermann C. Altmeppen
Published 2018-04-01

Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.

by Peter W Janes, Sabine H Wimmer-Kleikamp, Achilleas S Frangakis, Kane Treble, Bettina Griesshaber, Ola Sabet, Markus Grabenbauer, Alice Y Ting, Paul Saftig, Philippe I Bastiaens, Martin Lackmann
Published 2009-10-01

LAMP3 deficiency affects surfactant homeostasis in mice.

by Lars P Lunding, Daniel Krause, Guido Stichtenoth, Cordula Stamme, Niklas Lauterbach, Jan Hegermann, Matthias Ochs, Björn Schuster, Radislav Sedlacek, Paul Saftig, Dominik Schwudke, Michael Wegmann, Markus Damme
Published 2021-06-01