Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells

by Hideyuki Hara, Junji Chida, Keiji Uchiyama, Agriani Dini Pasiana, Etsuhisa Takahashi, Hiroshi Kido, Suehiro Sakaguchi
Published 2021-05-01

Prions amplify through degradation of the VPS10P sorting receptor sortilin.

by Keiji Uchiyama, Mitsuru Tomita, Masashi Yano, Junji Chida, Hideyuki Hara, Nandita Rani Das, Anders Nykjaer, Suehiro Sakaguchi
Published 2017-06-01

Biological and biochemical characterization of mice expressing prion protein devoid of the octapeptide repeat region after infection with prions.

by Yoshitaka Yamaguchi, Hironori Miyata, Keiji Uchiyama, Akira Ootsuyama, Sachiko Inubushi, Tsuyoshi Mori, Naomi Muramatsu, Shigeru Katamine, Suehiro Sakaguchi
Published 2012-01-01

Ethanolamine Is a New Anti-Prion Compound

by Keiji Uchiyama, Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Morikazu Imamura, Tsuyoshi Mori, Hanae Takatsuki, Ryuichiro Atarashi, Suehiro Sakaguchi
Published 2021-10-01

Mouse-hamster chimeric prion protein (PrP) devoid of N-terminal residues 23-88 restores susceptibility to 22L prions, but not to RML prions in PrP-knockout mice.

by Keiji Uchiyama, Hironori Miyata, Masashi Yano, Yoshitaka Yamaguchi, Morikazu Imamura, Naomi Muramatsu, Nandita Rani Das, Junji Chida, Hideyuki Hara, Suehiro Sakaguchi
Published 2014-01-01

Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire

by Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Keiji Uchiyama, Yutaka Kikuchi, Tomoko Naito, Yuichi Takahashi, Junji Yamamura, Hisashi Kuromatsu, Suehiro Sakaguchi
Published 2021-03-01

Prion protein protects mice from lethal infection with influenza A viruses.

by Junji Chida, Hideyuki Hara, Masashi Yano, Keiji Uchiyama, Nandita Rani Das, Etsuhisa Takahashi, Hironori Miyata, Yukiko Tomioka, Toshihiro Ito, Hiroshi Kido, Suehiro Sakaguchi
Published 2018-05-01

Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice.

by Junji Chida, Hideyuki Hara, Keiji Uchiyama, Etsuhisa Takahashi, Hironori Miyata, Hidetaka Kosako, Yukiko Tomioka, Toshihiro Ito, Hiroyuki Horiuchi, Haruo Matsuda, Hiroshi Kido, Suehiro Sakaguchi
Published 2020-08-01

Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91–106

by Keiji Uchiyama, Hironori Miyata, Yoshitaka Yamaguchi, Morikazu Imamura, Mariya Okazaki, Agriani Dini Pasiana, Junji Chida, Hideyuki Hara, Ryuichiro Atarashi, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi
Published 2020-10-01

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

by Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel, Hermann C. Altmeppen
Published 2018-04-01