Externally-Controlled Systems for Immunotherapy: From Bench to Bedside

by María Tristán-Manzano, Pedro Justicia-Lirio, Pedro Justicia-Lirio, Noelia Maldonado-Pérez, Marina Cortijo-Gutiérrez, Karim Benabdellah, Francisco Martin
Published 2020-09-01

Exosome: A New Player in Translational Nanomedicine

by Houssam Aheget, María Tristán-Manzano, Loubna Mazini, Marina Cortijo-Gutierrez, Pablo Galindo-Moreno, Concha Herrera, Francisco Martin, Juan Antonio Marchal, Karim Benabdellah
Published 2020-07-01

Development of Cellular Models to Study Efficiency and Safety of Gene Edition by Homologous Directed Recombination Using the CRISPR/Cas9 System

by Sabina Sánchez-Hernández, Araceli Aguilar-González, Beatriz Guijarro-Albaladejo, Noelia Maldonado-Pérez, Iris Ramos-Hernández, Marina Cortijo-Gutiérrez, Rosario María Sánchez Martín, Karim Benabdellah, Francisco Martin
Published 2020-06-01

Improved Functionality of Integration-Deficient Lentiviral Vectors (IDLVs) by the Inclusion of IS₂ Protein Docks

by Marina Cortijo-Gutiérrez, Sabina Sánchez-Hernández, María Tristán-Manzano, Noelia Maldonado-Pérez, Lourdes Lopez-Onieva, Pedro J. Real, Concha Herrera, Juan Antonio Marchal, Francisco Martin, Karim Benabdellah
Published 2021-08-01

Genome‐edited adult stem cells: Next‐generation advanced therapy medicinal products

by Karim Benabdellah, Sabina Sánchez‐Hernández, Araceli Aguilar‐González, Noelia Maldonado‐Pérez, Alejandra Gutierrez‐Guerrero, Marina Cortijo‐Gutierrez, Iris Ramos‐Hernández, María Tristán‐Manzano, Pablo Galindo‐Moreno, Concha Herrera, Francisco Martin
Published 2020-06-01

Using Gene Editing Approaches to Fine-Tune the Immune System

by Kristina Pavlovic, Kristina Pavlovic, María Tristán-Manzano, Noelia Maldonado-Pérez, Marina Cortijo-Gutierrez, Sabina Sánchez-Hernández, Pedro Justicia-Lirio, Pedro Justicia-Lirio, M. Dolores Carmona, Concha Herrera, Concha Herrera, Francisco Martin, Karim Benabdellah
Published 2020-09-01

Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells

by María Tristán-Manzano, Noelia Maldonado-Pérez, Pedro Justicia-Lirio, Marina Cortijo-Gutierréz, Pablo Tristán-Ramos, Carlos Blanco-Benítez, Kristina Pavlovic, Araceli Aguilar-González, Pilar Muñoz, Francisco J. Molina-Estevez, Valerie Griesche, Juan Antonio Marchal, Sara R. Heras, Karim Benabdellah, Francisco Martin
Published 2023-06-01

The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes

by Sabina Sánchez-Hernández, Alejandra Gutierrez-Guerrero, Rocío Martín-Guerra, Marina Cortijo-Gutierrez, María Tristán-Manzano, Sandra Rodriguez-Perales, Laura Sanchez, Jose Luis Garcia-Perez, Jesus Chato-Astrain, Ricardo Fernandez-Valades, Ana Belén Carrillo-Galvez, Per Anderson, Rosa Montes, Pedro J. Real, Francisco Martin, Karim Benabdellah
Published 2018-12-01

Physiological lentiviral vectors for the generation of improved CAR-T cells

by María Tristán-Manzano, Noelia Maldonado-Pérez, Pedro Justicia-Lirio, Pilar Muñoz, Marina Cortijo-Gutiérrez, Kristina Pavlovic, Rosario Jiménez-Moreno, Sonia Nogueras, M. Dolores Carmona, Sabina Sánchez-Hernández, Araceli Aguilar-González, María Castella, Manel Juan, Concepción Marañón, Juan Antonio Marchal, Karim Benabdellah, Concha Herrera, Francisco Martin
Published 2022-06-01

Physiological lentiviral vectors for the generation of improved CAR-T cells

by María Tristán-Manzano, Noelia Maldonado-Pérez, Pedro Justicia-Lirio, Pilar Muñoz, Marina Cortijo-Gutiérrez, Kristina Pavlovic, Rosario Jiménez-Moreno, Sonia Nogueras, M. Dolores Carmona, Sabina Sánchez-Hernández, Araceli Aguilar-González, María Castella, Manel Juan, Concepción Marañón, Juan Antonio Marchal, Karim Benabdellah, Concha Herrera, Francisco Martin
Published 2022-09-01

Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma

by Noelia Maldonado-Pérez, María Tristán-Manzano, María Tristán-Manzano, Pedro Justicia-Lirio, Pedro Justicia-Lirio, Elena Martínez-Planes, Pilar Muñoz, Pilar Muñoz, Kristina Pavlovic, Kristina Pavlovic, Marina Cortijo-Gutiérrez, Carlos Blanco-Benítez, Carlos Blanco-Benítez, María Castella, Manel Juan, Mathias Wenes, Pedro Romero, Francisco J. Molina-Estévez, Concepción Marañón, Concha Herrera, Karim Benabdellah, Francisco Martin, Francisco Martin
Published 2022-10-01

Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy

by José L. Blaya-Cánovas, Carmen Griñán-Lisón, Isabel Blancas, Juan A. Marchal, César Ramírez-Tortosa, Araceli López-Tejada, Karim Benabdellah, Marina Cortijo-Gutiérrez, M. Victoria Cano-Cortés, Pablo Graván, Saúl A. Navarro-Marchal, Jaime Gómez-Morales, Violeta Delgado-Almenta, Jesús Calahorra, María Agudo-Lera, Amaia Sagarzazu, Carlos J. Rodríguez-González, Tania Gallart-Aragón, Christina Eich, Rosario M. Sánchez-Martín, Sergio Granados-Principal
Published 2024-05-01

Generating universal anti-CD19 CAR T cells with a defined memory phenotype by CRISPR/Cas9 editing and safety evaluation of the transcriptome

by Kristina Pavlovic, Kristina Pavlovic, MDolores Carmona-Luque, Giulia I. Corsi, Noelia Maldonado-Pérez, Francisco J. Molina-Estevez, Esther Peralbo-Santaella, Marina Cortijo-Gutiérrez, Pedro Justicia-Lirio, María Tristán-Manzano, Víctor Ronco-Díaz, Antonio Ballesteros-Ribelles, Alejandro Millán-López, Paula Heredia-Velázquez, Paula Heredia-Velázquez, Carla Fuster-García, Toni Cathomen, Stefan E. Seemann, Jan Gorodkin, Francisco Martin, Francisco Martin, Francisco Martin, Concha Herrera, Concha Herrera, Concha Herrera, Karim Benabdellah
Published 2024-05-01