CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling

by Raul Torres-Ruiz, Sandra Rodriguez-Perales
Published 2015-09-01

Modeling mixed-lineage-rearranged leukemia initiation in CD34+ cells: a “CRISPR” solution

by Raúl Torres-Ruiz, Sandra Rodriguez-Perales, Clara Bueno, Pablo Menendez
Published 2017-09-01

CRISPR/Cas9 for Cancer Therapy: Hopes and Challenges

by Marta Martinez-Lage, Pilar Puig-Serra, Pablo Menendez, Raul Torres-Ruiz, Sandra Rodriguez-Perales
Published 2018-11-01

Functional characterization of two enhancers located downstream FOXP2

by Raúl Torres-Ruiz, Antonio Benítez-Burraco, Marta Martínez-Lage, Sandra Rodríguez-Perales, Paloma García-Bellido
Published 2019-05-01

Detection of chromosome instability by interphase FISH in mouse and human tissues

by Raul Torres-Ruiz, Tatiana P. Grazioso, Marta Brandt, Marta Martinez-Lage, Sandra Rodriguez-Perales, Nabil Djouder
Published 2021-09-01

Functional Characterization of a Dual Enhancer/Promoter Regulatory Element Leading Human CD69 Expression

by Jennifer Redondo-Antón, MG Fontela, Laura Notario, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Elena Lorente, Pilar Lauzurica
Published 2020-10-01

Fast Diffusion Sustains Plasma Membrane Accumulation of Phosphatase of Regenerating Liver-1

by Patricia Castro-Sánchez, Sara Hernández-Pérez, Oscar Aguilar-Sopeña, Rocia Ramírez-Muñoz, Sandra Rodríguez-Perales, Raúl Torres-Ruiz, Pedro Roda-Navarro
Published 2020-12-01

CRISPR Approaches for the Diagnosis of Human Diseases

by Pilar Puig-Serra, Maria Cruz Casado-Rosas, Marta Martinez-Lage, Beatriz Olalla-Sastre, Alejandro Alonso-Yanez, Raul Torres-Ruiz, Sandra Rodriguez-Perales
Published 2022-02-01

Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling

by Barbara Oldrini, Álvaro Curiel-García, Carolina Marques, Veronica Matia, Özge Uluçkan, Osvaldo Graña-Castro, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Jason T. Huse, Massimo Squatrito
Published 2018-04-01

Restored glyoxylate metabolism after AGXT gene correction and direct reprogramming of primary hyperoxaluria type 1 fibroblasts

by Virginia Nieto-Romero, Aida García-Torralba, Andrea Molinos-Vicente, Francisco José Moya, Sandra Rodríguez-Perales, Ramón García-Escudero, Eduardo Salido, José-Carlos Segovia, María García-Bravo
Published 2024-04-01

RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment

by Alvaro Torres-Gomez, Jose Luis Sanchez-Trincado, Víctor Toribio, Raul Torres-Ruiz, Sandra Rodríguez-Perales, María Yáñez-Mó, Pedro A. Reche, Carlos Cabañas, Esther M. Lafuente
Published 2020-05-01

Abrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22)

by Ana Rio-Machín, Juliane Menezes, Alba Maiques-Diaz, Xabier Agirre, Bibiana I. Ferreira, Francesco Acquadro, Sandra Rodriguez-Perales, Karmele A. Juaristi, Sara Álvarez, Juan C. Cigudosa
Published 2012-04-01

Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the “safe harbor” AAVS1 locus

by Julio Castaño, Clara Bueno, Senda Jiménez-Delgado, Heleia Roca-Ho, Mario F. Fraga, Agustín F. Fernandez, Mahito Nakanishi, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Pablo Menéndez
Published 2017-05-01

Efficient Recreation of t(11;22) EWSR1-FLI1+ in Human Stem Cells Using CRISPR/Cas9

by Raul Torres-Ruiz, Marta Martinez-Lage, Maria C. Martin, Aida Garcia, Clara Bueno, Julio Castaño, Juan C. Ramirez, Pablo Menendez, Juan C. Cigudosa, Sandra Rodriguez-Perales
Published 2017-05-01

Narrowing the Genetic Causes of Language Dysfunction in the 1q21.1 Microduplication Syndrome

by Antonio Benítez-Burraco, Montserrat Barcos-Martínez, Montserrat Barcos-Martínez, Isabel Espejo-Portero, Isabel Espejo-Portero, Maite Fernández-Urquiza, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Ma Salud Jiménez-Romero
Published 2018-06-01

Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid–Base Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel Mechanism for a Co-Occurring Polyautoimmune Scenario

by Oriol Calvete, José Reyes, Hernán Valdés-Socin, Paloma Martin, Mónica Marazuela, Alicia Barroso, Javier Escalada, Antoni Castells, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, María Currás-Freixes, Javier Benítez
Published 2021-12-01

Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression

by Lin Li-Bao, Covadonga Díaz-Díaz, Morena Raiola, Rocío Sierra, Susana Temiño, Francisco J. Moya, Sandra Rodriguez-Perales, Elisa Santos, Giovanna Giovinazzo, Tore Bleckwehl, Álvaro Rada-Iglesias, Francois Spitz, Miguel Torres
Published 2024-05-01

Robustness of Catalytically Dead Cas9 Activators in Human Pluripotent and Mesenchymal Stem Cells

by Paolo Petazzi, Raul Torres-Ruiz, Antonella Fidanza, Heleia Roca-Ho, Francisco Gutierrez-Agüera, Julio Castaño, Sandra Rodriguez-Perales, Rafael Díaz de la Guardia, Belén López-Millán, Anna Bigas, Lesley M. Forrester, Clara Bueno, Pablo Menéndez
Published 2020-06-01

OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells

by Juan Miguel Baquero, Erik Marchena-Perea, Rocío Mirabet, Raúl Torres-Ruiz, Raúl Torres-Ruiz, Carmen Blanco-Aparicio, Sandra Rodríguez-Perales, Thomas Helleday, Thomas Helleday, Carlos Benítez-Buelga, Javier Benítez, Javier Benítez, Ana Osorio, Ana Osorio, Ana Osorio
Published 2022-05-01

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

by Juan Miguel Baquero, Carlos Benítez-Buelga, Varshni Rajagopal, Zhao Zhenjun, Raúl Torres-Ruiz, Sarah Müller, Bishoy M. F. Hanna, Olga Loseva, Olov Wallner, Maurice Michel, Sandra Rodríguez-Perales, Helge Gad, Torkild Visnes, Thomas Helleday, Javier Benítez, Ana Osorio
Published 2021-02-01