Impact of radiopacified bone cement on radiotherapy dose calculation

by Scott B. Crowe, Jane Bennett, Marika Lathouras, Craig M. Lancaster, Steven R. Sylvander, Benjamin Chua, Catherine S. Bettington, Charles Y. Lin, Tanya Kairn
Published 2020-04-01

Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape

by Behnam Nabet, Pilib Ó Broin, Jaime M. Reyes, Kevin Shieh, Charles Y. Lin, Christine M. Will, Relja Popovic, Teresa Ezponda, James E. Bradner, Aaron A. Golden, Jonathan D. Licht
Published 2015-08-01

Development of a customisable 3D-printed intra-oral stent for head-and-neck radiotherapy

by Susannah Cleland, Scott B. Crowe, Philip Chan, Benjamin Chua, Jodi Dawes, Lizbeth Kenny, Charles Y. Lin, William R. McDowall, Elise Obereigner, Tania Poroa, Kate Stewart, Tanya Kairn
Published 2022-09-01

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer

by Jennifer M. Spangle, Koen M. Dreijerink, Anna C. Groner, Hailing Cheng, Carolynn E. Ohlson, Jaime Reyes, Charles Y. Lin, James Bradner, Jean J. Zhao, Thomas M. Roberts, Myles Brown
Published 2016-06-01

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA

by Matthew S. Stratton, Charles Y. Lin, Priti Anand, Philip D. Tatman, Bradley S. Ferguson, Sean T. Wickers, Amrut V. Ambardekar, Carmen C. Sucharov, James E. Bradner, Saptarsi M. Haldar, Timothy A. McKinsey
Published 2016-08-01

Targeting the Apoa1 locus for liver-directed gene therapy

by Marco De Giorgi, Ang Li, Ayrea Hurley, Mercedes Barzi, Alexandria M. Doerfler, Nikitha A. Cherayil, Harrison E. Smith, Jonathan D. Brown, Charles Y. Lin, Karl-Dimiter Bissig, Gang Bao, William R. Lagor
Published 2021-06-01

Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma

by Mariateresa Fulciniti, Charles Y. Lin, Mehmet K. Samur, Michael A. Lopez, Irtisha Singh, Matthew A. Lawlor, Raphael E. Szalat, Christopher J. Ott, Herve’ Avet-Loiseau, Kenneth C. Anderson, Richard A. Young, James E. Bradner, Nikhil C. Munshi
Published 2018-12-01

Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer

by Koen M.A. Dreijerink, Anna C. Groner, Erica S.M. Vos, Alba Font-Tello, Lei Gu, David Chi, Jaime Reyes, Jennifer Cook, Elgene Lim, Charles Y. Lin, Wouter de Laat, Prakash K. Rao, Henry W. Long, Myles Brown
Published 2017-03-01

Targeting transcription in heart failure via CDK7/12/13 inhibition

by Austin Hsu, Qiming Duan, Daniel S. Day, Xin Luo, Sarah McMahon, Yu Huang, Zachary B. Feldman, Zhen Jiang, Tinghu Zhang, Yanke Liang, Michael Alexanian, Arun Padmanabhan, Jonathan D. Brown, Charles Y. Lin, Nathanael S. Gray, Richard A. Young, Benoit G. Bruneau, Saptarsi M. Haldar
Published 2022-07-01

PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

by Melusine Bleu, Swann Gaulis, Rui Lopes, Kathleen Sprouffske, Verena Apfel, Sjoerd Holwerda, Marco Pregnolato, Umut Yildiz, Valentina Cordoʹ, Antonella F. M. Dost, Judith Knehr, Walter Carbone, Felix Lohmann, Charles Y. Lin, James E. Bradner, Audrey Kauffmann, Luca Tordella, Guglielmo Roma, Giorgio G. Galli
Published 2019-08-01

Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression

by Cody T. Mowery, Jaime M. Reyes, Lucia Cabal-Hierro, Kelly J. Higby, Kristen L. Karlin, Jarey H. Wang, Robert J. Kimmerling, Paloma Cejas, Klothilda Lim, Hubo Li, Takashi Furusawa, Henry W. Long, David Pellman, Bjoern Chapuy, Michael Bustin, Scott R. Manalis, Thomas F. Westbrook, Charles Y. Lin, Andrew A. Lane
Published 2018-11-01

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

by Mei Zeng, Nicholas P Kwiatkowski, Tinghu Zhang, Behnam Nabet, Mousheng Xu, Yanke Liang, Chunshan Quan, Jinhua Wang, Mingfeng Hao, Sangeetha Palakurthi, Shan Zhou, Qing Zeng, Paul T Kirschmeier, Khyati Meghani, Alan L Leggett, Jun Qi, Geoffrey I Shapiro, Joyce F Liu, Ursula A Matulonis, Charles Y Lin, Panagiotis A Konstantinopoulos, Nathanael S Gray
Published 2018-11-01

IRF2 is a master regulator of human keratinocyte stem cell fate

by Nicolas Mercado, Gabi Schutzius, Christian Kolter, David Estoppey, Sebastian Bergling, Guglielmo Roma, Caroline Gubser Keller, Florian Nigsch, Adrian Salathe, Remi Terranova, John Reece-Hoyes, John Alford, Carsten Russ, Judith Knehr, Dominic Hoepfner, Alexandra Aebi, Heinz Ruffner, Tanner C. Beck, Sajjeev Jagannathan, Calla M. Olson, Hadley E. Sheppard, Selma Z. Elsarrag, Tewis Bouwmeester, Mathias Frederiksen, Felix Lohmann, Charles Y. Lin, Susan Kirkland
Published 2019-10-01

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

by David P. Labbé, Giorgia Zadra, Meng Yang, Jaime M. Reyes, Charles Y. Lin, Stefano Cacciatore, Ericka M. Ebot, Amanda L. Creech, Francesca Giunchi, Michelangelo Fiorentino, Habiba Elfandy, Sudeepa Syamala, Edward D. Karoly, Mohammed Alshalalfa, Nicholas Erho, Ashley Ross, Edward M. Schaeffer, Ewan A. Gibb, Mandeep Takhar, Robert B. Den, Jonathan Lehrer, R. Jeffrey Karnes, Stephen J. Freedland, Elai Davicioni, Daniel E. Spratt, Leigh Ellis, Jacob D. Jaffe, Anthony V. DʼAmico, Philip W. Kantoff, James E. Bradner, Lorelei A. Mucci, Jorge E. Chavarro, Massimo Loda, Myles Brown
Published 2019-09-01

DHODH modulates transcriptional elongation in the neural crest and melanoma

by White, Richard Mark, Cech, Jennifer, Ratanasirintrawoot, Sutheera, Lin, Charles P., Rahl, Peter B., Burke, Christopher J., Langdon, Erin, Tomlinson, Matthew L., Mosher, Jack, Kaufman, Charles Kore, Chen, Frank, Long, Hannah K., Kramer, Martin, Datta, Sumon Michael, Neuberg, Donna S., Granter, Scott R., Young, Richard A., Morrison, Sean, Wheeler, Grant N., Zon, Leonard Ira
Published 2017

Revisiting Global Gene Expression Analysis

by Loven, Jakob, Orlando, David A., Sigova, Alla A., Lin, Charles Y., Rahl, Peter B., Burge, Christopher B., Levens, David L., Lee, Tong Ihn, Young, Richard A.
Published 2015

SR Proteins Collaborate with 7SK and Promoter-Associated Nascent RNA to Release Paused Polymerase

by Ji, Xiong, Zhou, Yu, Pandit, Shatakshi, Huang, Jie, Li, Hairi, Lin, Charles Y., Xiao, Rui, Fu, Xiang-Dong, Burge, Christopher B
Published 2015

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

by Loven, Jakob, Hoke, Heather Ashley, Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.
Published 2014

Models of human core transcriptional regulatory circuitries

by Saint-André, Violaine, Federation, Alexander J., Lin, Charles Y., Abraham, Brian J., Lee, Tong Ihn, Bradner, James E., Reddy, Jessica, Young, Richard A.
Published 2017

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

by Whyte, Warren A., Orlando, David A., Hnisz, Denes, Abraham, Brian J., Lin, Charles Y., Kagey, Michael H., Rahl, Peter B., Lee, Tong Ihn, Young, Richard A., Young, Richard A.
Published 2016