Targeting EZH2 in Multiple Myeloma—Multifaceted Anti-Tumor Activity

by Mohammad Alzrigat, Helena Jernberg-Wiklund, Jonathan D. Licht
Published 2018-09-01

Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis.

by Kelly M Arcipowski, Marinka Bulic, Sandeep Gurbuxani, Jonathan D Licht
Published 2016-01-01

The role of sex and rurality in cancer fatalistic beliefs and cancer screening utilization in Florida

by Yi Guo, Sarah M. Szurek, Jiang Bian, Dejana Braithwaite, Jonathan D. Licht, Elizabeth A. Shenkman
Published 2021-09-01

Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1.

by Sam Collins, Adam Waickman, Albert Basson, Abraham Kupfer, Jonathan D Licht, Maureen R Horton, Jonathan D Powell
Published 2012-01-01

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

by Jung Kim, Yongik Lee, Xiaodong Lu, Bing Song, Ka-Wing Fong, Qi Cao, Jonathan D. Licht, Jonathan C. Zhao, Jindan Yu
Published 2018-12-01

Kidney development in the absence of Gdnf and Spry1 requires Fgf10.

by Odyssé Michos, Cristina Cebrian, Deborah Hyink, Uta Grieshammer, Linda Williams, Vivette D'Agati, Jonathan D Licht, Gail R Martin, Frank Costantini
Published 2010-01-01

Cancer disparities related to poverty and rurality for 22 top cancers in Florida

by Jaclyn M. Hall, Sarah M. Szurek, Heedeok Cho, Yi Guo, Michael S. Gutter, Georges E. Khalil, Jonathan D. Licht, Elizabeth A. Shenkman
Published 2022-10-01

Cancer incidence after asthma diagnosis: Evidence from a large clinical research network in the United States

by Yi Guo, Jiang Bian, Zhaoyi Chen, Jennifer N. Fishe, Dongyu Zhang, Dejana Braithwaite, Thomas J. George, Elizabeth A. Shenkman, Jonathan D. Licht
Published 2023-05-01

A Pathologic Link between Wilms Tumor Suppressor Gene, WT1, and IFI16

by Marianne K-H. Kim, Jacqueline M. Mason, Chi-Ming Li, Windy Berkofsky-Fessler, Le Jiang, Divaker Choubey, Paul E. Grundy, Benjamin Tycko, Jonathan D. Licht
Published 2008-01-01

FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

by Yue Sheng, Chunjie Yu, Yin Liu, Chao Hu, Rui Ma, Xinyan Lu, Peng Ji, Jianjun Chen, Benjamin Mizukawa, Yong Huang, Jonathan D. Licht, Zhijian Qian
Published 2020-02-01

Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape

by Behnam Nabet, Pilib Ó Broin, Jaime M. Reyes, Kevin Shieh, Charles Y. Lin, Christine M. Will, Relja Popovic, Teresa Ezponda, James E. Bradner, Aaron A. Golden, Jonathan D. Licht
Published 2015-08-01

BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in<br /> Class 2 Uveal Melanomas

by Christopher J. Kaler, James J. Dollar, Anthony M. Cruz, Jeffim N. Kuznetsoff, Margaret I. Sanchez, Christina L. Decatur, Jonathan D. Licht, Keiran S. M. Smalley, Zelia M. Correa, Stefan Kurtenbach, J. William Harbour
Published 2022-07-01

HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis

by Michael F. Emmons, Richard L. Bennett, Alberto Riva, Kanchan Gupta, Larissa Anastasio Da Costa Carvalho, Chao Zhang, Robert Macaulay, Daphne Dupéré-Richér, Bin Fang, Edward Seto, John M. Koomen, Jiannong Li, Y. Ann Chen, Peter A. Forsyth, Jonathan D. Licht, Keiran S. M. Smalley
Published 2023-11-01

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition

by Teresa Ezponda, Daphné Dupéré-Richer, Christine M. Will, Eliza C. Small, Nobish Varghese, Tej Patel, Behnam Nabet, Relja Popovic, Jon Oyer, Marinka Bulic, Yupeng Zheng, Xiaoxiao Huang, Mrinal Y. Shah, Sayantan Maji, Alberto Riva, Manuela Occhionorelli, Giovanni Tonon, Neil Kelleher, Jonathan Keats, Jonathan D. Licht
Published 2017-10-01

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.

by Relja Popovic, Eva Martinez-Garcia, Eugenia G Giannopoulou, Quanwei Zhang, Qingyang Zhang, Teresa Ezponda, Mrinal Y Shah, Yupeng Zheng, Christine M Will, Eliza C Small, Youjia Hua, Marinka Bulic, Yanwen Jiang, Matteo Carrara, Raffaele A Calogero, William L Kath, Neil L Kelleher, Ji-Ping Wang, Olivier Elemento, Jonathan D Licht
Published 2014-09-01

First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival

by Maria V. Guijarro, Patrick C. Kellish, Peter E. Dib, Nicholas G. Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Nicholas V. Borrero, Carlos Modenutti, Michael Feely, Elham Nasri, Robert P. Seifert, Xiaoping Luo, Richard L. Bennett, Daniil Shabashvili, Jonathan D. Licht, Robert McKenna, Adrian Roitberg, Robert W. Huigens III, Frederic J. Kaye, Maria Zajac-Kaye
Published 2023-05-01

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia

by Barry M. Zee, Kamrine E. Poels, Cong-Hui Yao, Kimihito C. Kawabata, Gongwei Wu, Cihangir Duy, William D. Jacobus, Elizabeth Senior, Jennifer E. Endress, Ashwini Jambhekar, Scott B. Lovitch, Jiexian Ma, Abhinav Dhall, Isaac S. Harris, M. Andres Blanco, David B. Sykes, Jonathan D. Licht, David M. Weinstock, Ari Melnick, Marcia C. Haigis, Franziska Michor, Yang Shi
Published 2021-06-01

DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

by Raajit Rampal, Altuna Alkalin, Jozef Madzo, Aparna Vasanthakumar, Elodie Pronier, Jay Patel, Yushan Li, Jihae Ahn, Omar Abdel-Wahab, Alan Shih, Chao Lu, Patrick S. Ward, Jennifer J. Tsai, Todd Hricik, Valeria Tosello, Jacob E. Tallman, Xinyang Zhao, Danette Daniels, Qing Dai, Luisa Ciminio, Iannis Aifantis, Chuan He, Francois Fuks, Martin S. Tallman, Adolfo Ferrando, Stephen Nimer, Elisabeth Paietta, Craig B. Thompson, Jonathan D. Licht, Christopher E. Mason, Lucy A. Godley, Ari Melnick, Maria E. Figueroa, Ross L. Levine
Published 2014-12-01

SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck

by Nupur Nigam, Benjamin Bernard, Samantha Sevilla, Sohyoung Kim, Mohd Saleem Dar, Daniel Tsai, Yvette Robbins, Kyunghee Burkitt, Cem Sievers, Clint T. Allen, Richard L. Bennett, Theophilus T. Tettey, Benjamin Carter, Lorenzo Rinaldi, Mark W. Lingen, Houssein Sater, Elijah F. Edmondson, Arfa Moshiri, Abbas Saeed, Hui Cheng, Xiaolin Luo, Kevin Brennan, Vishal Koparde, Chen Chen, Sudipto Das, Thorkell Andresson, Abdalla Abdelmaksoud, Madhavi Murali, Seiji Sakata, Kengo Takeuchi, Raj Chari, Yusuke Nakamura, Ravindra Uppaluri, John B. Sunwoo, Carter Van Waes, Jonathan D. Licht, Gordon L. Hager, Vassiliki Saloura
Published 2023-07-01

Kidney Development in the Absence of Gdnf and Spry1 Requires Fgf10

by Michos, Odyssé, Cebrian, Cristina, Hyink, Deborah, Grieshammer, Uta, Williams, Linda, D'Agati, Vivette, Licht, Jonathan D., Martin, Gail R., Costantini, Frank
Published 2012