Targeting tumor-associated macrophages with STING agonism improves the antitumor efficacy of osimertinib in a mouse model of EGFR-mutant lung cancer

by Ziying Lin, Ziying Lin, Qiwei Wang, Qiwei Wang, Qiwei Wang, Tao Jiang, Weihua Wang, Jean J. Zhao, Jean J. Zhao, Jean J. Zhao, Jean J. Zhao
Published 2023-02-01

Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss

by Onur Cizmecioglu, Jing Ni, Shaozhen Xie, Jean J Zhao, Thomas M Roberts
Published 2016-10-01

A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells

by Yubao Wang, Ben B. Li, Jing Li, Thomas M. Roberts, Jean J. Zhao
Published 2018-11-01

The role of the PIK3CA gene in the development and aging of the brain

by Shaozhen Xie, Jing Ni, Hanbing Guo, Victor Luu, Yanzhi Wang, Jean J. Zhao, Thomas M. Roberts
Published 2021-01-01

CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells

by Jing Zhang, Xueliang Gao, Fabienne Schmit, Guillaume Adelmant, Michael J. Eck, Jarrod A. Marto, Jean J. Zhao, Thomas M. Roberts
Published 2017-07-01

Pik3ca is required for mouse uterine gland development and pregnancy.

by Hye Jin Chang, Hee Sung Shin, Tae Hoon Kim, Jung-Yoon Yoo, Hanna E Teasley, Jean J Zhao, Un-Hwan Ha, Jae-Wook Jeong
Published 2018-01-01

Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy

by Achira Roy, Jonathan Skibo, Franck Kalume, Jing Ni, Sherri Rankin, Yiling Lu, William B Dobyns, Gordon B Mills, Jean J Zhao, Suzanne J Baker, Kathleen J Millen
Published 2015-12-01

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer

by Jennifer M. Spangle, Koen M. Dreijerink, Anna C. Groner, Hailing Cheng, Carolynn E. Ohlson, Jaime Reyes, Charles Y. Lin, James Bradner, Jean J. Zhao, Thomas M. Roberts, Myles Brown
Published 2016-06-01

p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases

by Jing Ni, Sheheryar Kabraji, Shaozhen Xie, Yanzhi Wang, Peichen Pan, Xiaofang He, Zongming Liu, Jose Palbo Leone, Henry W. Long, Myles A. Brown, Eric P. Winer, Deborah A. R. Dillon, Nancy U. Lin, Jean J. Zhao
Published 2022-03-01

Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

by Yubao Wang, Young-Mi Li, Lukas Baitsch, Alan Huang, Yi Xiang, Haoxuan Tong, Ana Lako, Thanh Von, Christine Choi, Elgene Lim, Junxia Min, Li Li, Frank Stegmeier, Robert Schlegel, Michael J Eck, Nathanael S Gray, Timothy J Mitchison, Jean J Zhao
Published 2018-03-01

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

by Yubao Wang, Young-Mi Lee, Lukas Baitsch, Alan Huang, Yi Xiang, Haoxuan Tong, Ana Lako, Thanh Von, Christine Choi, Elgene Lim, Junxia Min, Li Li, Frank Stegmeier, Robert Schlegel, Michael J Eck, Nathanael S Gray, Timothy J Mitchison, Jean J Zhao
Published 2014-05-01

STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

by Changli Qian, Gordon J Freeman, Tao Jiang, Ursula Matulonis, Ziying Lin, Hye-Jung Kim, Anniina Färkkilä, Hua Yu, Xin Cheng, Antons Martincuks, Joyce F Liu, Qiwei Wang, Liya Ding, Michael J Kearns, Shaozhen Xie, Inga-Maria Launonen, Thomas M Roberts, Jean J Zhao
Published 2023-01-01

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer

by Liya Ding, Hye-Jung Kim, Qiwei Wang, Michael Kearns, Tao Jiang, Carolynn E. Ohlson, Ben B. Li, Shaozhen Xie, Joyce F. Liu, Elizabeth H. Stover, Brooke E. Howitt, Roderick T. Bronson, Suzan Lazo, Thomas M. Roberts, Gordon J. Freeman, Panagiotis A. Konstantinopoulos, Ursula A. Matulonis, Jean J. Zhao
Published 2018-12-01

STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer

by Qiwei Wang, Johann S. Bergholz, Liya Ding, Ziying Lin, Sheheryar K. Kabraji, Melissa E. Hughes, Xiadi He, Shaozhen Xie, Tao Jiang, Weihua Wang, Jason J. Zoeller, Hye-Jung Kim, Thomas M. Roberts, Panagiotis A. Konstantinopoulos, Ursula A. Matulonis, Deborah A. Dillon, Eric P. Winer, Nancy U. Lin, Jean J. Zhao
Published 2022-05-01

MELK is not necessary for the proliferation of basal-like breast cancer cells

by Hai-Tsang Huang, Hyuk-Soo Seo, Tinghu Zhang, Yubao Wang, Baishan Jiang, Qing Li, Dennis L Buckley, Behnam Nabet, Justin M Roberts, Joshiawa Paulk, Shiva Dastjerdi, Georg E Winter, Hilary McLauchlan, Jennifer Moran, James E Bradner, Michael J Eck, Sirano Dhe-Paganon, Jean J Zhao, Nathanael S Gray
Published 2017-09-01

Therapeutic implications of GIPC1 silencing in cancer.

by Thomas W Chittenden, Jane Pak, Renee Rubio, Hailing Cheng, Kristina Holton, Niall Prendergast, Vladimir Glinskii, Yi Cai, Aedin Culhane, Stefan Bentink, Mathew Schwede, Jessica C Mar, Eleanor A Howe, Martin Aryee, Razvan Sultana, Anthony A Lanahan, Jennifer M Taylor, Chris Holmes, William C Hahn, Jean J Zhao, J Dirk Iglehart, John Quackenbush
Published 2010-12-01

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

by Ji Li, Peter S Choi, Christine L Chaffer, Katherine Labella, Justin H Hwang, Andrew O Giacomelli, Jong Wook Kim, Nina Ilic, John G Doench, Seav Huong Ly, Chao Dai, Kimberly Hagel, Andrew L Hong, Ole Gjoerup, Shom Goel, Jennifer Y Ge, David E Root, Jean J Zhao, Angela N Brooks, Robert A Weinberg, William C Hahn
Published 2018-07-01

A Genetic Screen for Candidate Tumor Suppressors Identifies REST

by Westbrook, Thomas F., Martin, Eric S., Schlabach, Michael R., Leng, Yumei, Liang, Anthony C., Feng, Bin, Zhao, Jean J., Roberts, Thomas M., Mandel, Gail, Hannon, Gregory J., DePinho, Ronald A., Chin, Lynda, Elledge, Stephen
Published 2019

Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss

by Cizmecioglu, Onur, Ni, Jing, Xie, Shaozhen, Zhao, Jean J, Roberts, Thomas M
Published 2016

ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor

by Simond, Alexandra M., Rao, Trisha, Zuo, Dongmei, Zhao, Jean J., Muller, William J.
Published 2018