The G2 checkpoint—a node‐based molecular switch

by Mark C. deGooijer, Arnout van denTop, Irena Bockaj, Jos H. Beijnen, Thomas Würdinger, Olaf vanTellingen
Published 2017-04-01

EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors.

by Serge A L Zander, Wendy Sol, Lee Greenberger, Yixian Zhang, Olaf van Tellingen, Jos Jonkers, Piet Borst, Sven Rottenberg
Published 2012-01-01

Identification of a Druggable Pathway Controlling Glioblastoma Invasiveness

by Nora Pencheva, Mark C. de Gooijer, Daniel J. Vis, Lodewyk F.A. Wessels, Tom Würdinger, Olaf van Tellingen, René Bernards
Published 2017-07-01

Acquired and intrinsic resistance to vemurafenib in BRAFV600E‐driven melanoma brain metastases

by Ping Zhang, Laura Esmee Kuil, Levi Conrad Maria Buil, Stephan Freriks, Jos Hendrik Beijnen, Olaf vanTellingen, Mark Cornelis deGooijer
Published 2024-01-01

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2

by Mark C. de Gooijer, Nienke A. de Vries, Tessa Buckle, Levi C.M. Buil, Jos H. Beijnen, Willem Boogerd, Olaf van Tellingen
Published 2018-07-01

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression

by Nienke A. de Vries, Danielle Hulsman, Waseem Akhtar, Johann de Jong, Denise C. Miles, Marleen Blom, Olaf van Tellingen, Jos Jonkers, Maarten van Lohuizen
Published 2015-01-01

Protocol for live-cell imaging during Tumor Treating Fields treatment with Inovitro Live

by Paul L.G. Slangen, Yaara Porat, Marjolijn Mertz, Bram van den Broek, Kees Jalink, Mark C. de Gooijer, Olaf van Tellingen, Gerben R. Borst
Published 2022-06-01

Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib

by Sali Al-Ansari, Rozita Jalali, Antonius L. J. J. Bronckers, Olaf van Tellingen, Judith Raber-Durlacher, Nasser Nadjmi, Alan Henry Brook, Jan de Lange, Frederik R. Rozema
Published 2022-07-01

Non-therapeutic plasma levels in individuals utilizing curcumin supplements in daily life

by Maurice A. G. M. Kroon, Jacqueline K. Berbee, Soumia Majait, Eleonora L. Swart, Olaf van Tellingen, Hanneke W. M. van Laarhoven, E. Marleen Kemper, E. Marleen Kemper
Published 2023-11-01

Validity of bioluminescence measurements for noninvasive in vivo imaging of tumor load in small animals

by Clara P.W. Klerk, Renée M. Overmeer, Tatjana M.H. Niers, Henri H. Versteeg, Dick J. Richel, Tessa Buckle, Cornelis J.F. Van Noorden, Olaf van Tellingen
Published 2007-07-01

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101).

by Pieter J Gaillard, Chantal C M Appeldoorn, Rick Dorland, Joan van Kregten, Francesca Manca, Danielle J Vugts, Bert Windhorst, Guus A M S van Dongen, Helga E de Vries, David Maussang, Olaf van Tellingen
Published 2014-01-01

Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs

by Wenlong Li, Dilek Iusuf, Rolf W. Sparidans, Els Wagenaar, Yaogeng Wang, Dirk R. de Waart, Margarida L.F. Martins, Stéphanie van Hoppe, Maria C. Lebre, Olaf van Tellingen, Jos H. Beijnen, Alfred H. Schinkel
Published 2023-04-01

Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs

by Wenlong Li, Rolf W. Sparidans, Yaogeng Wang, Margarida L.F. Martins, Dirk R. de Waart, Olaf van Tellingen, Ji-Ying Song, Maria C. Lebre, Stéphanie van Hoppe, Els Wagenaar, Jos H. Beijnen, Alfred H. Schinkel
Published 2024-06-01

Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients

by Xiaohang Qiao, Sabina Y. van der Zanden, Xiaoyang Li, Minkang Tan, Yunxiang Zhang, Ji-Ying Song, Merle A. van Gelder, Feija L. Hamoen, Lennert Janssen, Charlotte L. Zuur, Baoxu Pang, Olaf van Tellingen, Junmin Li, Jacques Neefjes
Published 2024-06-01

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

by Sander Mertens, Maarten A. Huismans, Carla S. Verissimo, Bas Ponsioen, Rene Overmeer, Natalie Proost, Olaf van Tellingen, Marieke van de Ven, Harry Begthel, Sylvia F. Boj, Hans Clevers, Jeanine M.L. Roodhart, Johannes L. Bos, Hugo J.G. Snippert
Published 2023-04-01

Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma

by Antonio Mulero‐Sánchez, Christel F. A. Ramirez, Aimée duChatinier, Hui Wang, Sofie J. I. Koomen, Ji‐Ying Song, Marnix H. P. deGroot, Cor Lieftink, Astrid Bosma, Artur Burylo, Olaf vanTellingen, Roderick L. Beijersbergen, Cun Wang, Leila Akkari, René Bernards, Sara Mainardi
Published 2023-06-01

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours

by João M. Fernandes Neto, Ernest Nadal, Evert Bosdriesz, Salo N. Ooft, Lourdes Farre, Chelsea McLean, Sjoerd Klarenbeek, Anouk Jurgens, Hannes Hagen, Liqin Wang, Enriqueta Felip, Alex Martinez-Marti, August Vidal, Emile Voest, Lodewyk F. A. Wessels, Olaf van Tellingen, Alberto Villanueva, René Bernards
Published 2020-06-01

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.

by Ziva Pogacar, Jackie L Johnson, Lenno Krenning, Giulia De Conti, Fleur Jochems, Cor Lieftink, Arno Velds, Leyma Wardak, Kelvin Groot, Arnout Schepers, Liqin Wang, Ji-Ying Song, Marieke van de Ven, Olaf van Tellingen, Rene H Medema, Roderick L Beijersbergen, Rene Bernards, Rodrigo Leite de Oliveira
Published 2022-01-01

Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8

by Jordi Berenguer, Tonny Lagerweij, Xi Wen Zhao, Sophie Dusoswa, Petra van der Stoop, Bart Westerman, Mark C. de Gooijer, Marloes Zoetemelk, Anoek Zomer, Matheus H. W. Crommentuijn, Laurine E. Wedekind, Àlan López-López, Alberta Giovanazzi, Marina Bruch-Oms, Ida H. van der Meulen-Muileman, Rogier M. Reijmers, Toin H. van Kuppevelt, Juan-Jesús García-Vallejo, Yvette van Kooyk, Bakhos A. Tannous, Pieter Wesseling, Danijela Koppers-Lalic, W. Peter Vandertop, David P. Noske, Victor W. van Beusechem, Jacco van Rheenen, D. Michiel Pegtel, Olaf van Tellingen, Thomas Wurdinger
Published 2018-12-01

The G2 checkpoint—a node‐based molecular switch

by de Gooijer, Mark C., van den Top, Arnout, Bockaj, Irena, Beijnen, Jos H., Würdinger, Thomas, van Tellingen, Olaf
Published 2017