It takes two to tango, and the right music: Synergistic drug combinations with cell-cycle phase-dependent sensitivities

by Cor Lieftink, Roderick L Beijersbergen
Published 2021-07-01

The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence.

by Jeroen H Nijwening, Ernst-Jan Geutjes, Rene Bernards, Roderick L Beijersbergen
Published 2011-01-01

A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway.

by Jasper Mullenders, Armida W M Fabius, Mandy Madiredjo, René Bernards, Roderick L Beijersbergen
Published 2009-01-01

A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways

by Martin F. M. de Rooij, Yvonne J. Thus, Nathalie Swier, Roderick L. Beijersbergen, Steven T. Pals, Marcel Spaargaren
Published 2022-04-01

A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing

by Miguel Vizoso, Colin E. J. Pritchard, Lorenzo Bombardelli, Bram van den Broek, Paul Krimpenfort, Roderick L. Beijersbergen, Kees Jalink, Jacco van Rheenen
Published 2022-10-01

A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

by Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards
Published 2018-11-01

Correction to: A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

by Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards
Published 2021-02-01

Widespread chromatin context-dependencies of DNA double-strand break repair proteins

by Xabier Vergara, Anna G. Manjón, Marcel de Haas, Ben Morris, Ruben Schep, Christ Leemans, Anoek Friskes, Roderick L. Beijersbergen, Mathijs A. Sanders, René H. Medema, Bas van Steensel
Published 2024-06-01

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

by Liqin Wang, Rodrigo Leite de Oliveira, Cun Wang, João M. Fernandes Neto, Sara Mainardi, Bastiaan Evers, Cor Lieftink, Ben Morris, Fleur Jochems, Lisa Willemsen, Roderick L. Beijersbergen, René Bernards
Published 2017-10-01

Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation

by Yvonne J. Thus, Martin F.M. de Rooij, Nathalie Swier, Roderick L. Beijersbergen, Jeroen E.J. Guikema, Marie-José Kersten, Eric Eldering, Steven T. Pals, Arnon P. Kater, Marcel Spaargaren
Published 2022-10-01

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs

by Anirudh Prahallad, Guus J.J.E. Heynen, Giovanni Germano, Stefan M. Willems, Bastiaan Evers, Loredana Vecchione, Valentina Gambino, Cor Lieftink, Roderick L. Beijersbergen, Federica Di Nicolantonio, Alberto Bardelli, Rene Bernards
Published 2015-09-01

The Cancer SENESCopedia: A delineation of cancer cell senescence

by Fleur Jochems, Bram Thijssen, Giulia De Conti, Robin Jansen, Ziva Pogacar, Kelvin Groot, Liqin Wang, Arnout Schepers, Cun Wang, Haojie Jin, Roderick L. Beijersbergen, Rodrigo Leite de Oliveira, Lodewyk F.A. Wessels, René Bernards
Published 2021-07-01

Sustained activation of EGFR-ERK1/2 signaling limits the response to tigecycline-induced mitochondrial respiratory deficiency in liver cancerResearch in context

by Yangyang Zhou, Siying Wang, Wei Wu, Jing Ling, Haoyu Li, Qi Jia, Jiaojiao Zheng, Xingling Zheng, Ruobing Yu, Qiangxin Wu, Yaoping Shi, Cor Lieftink, Roderick L. Beijersbergen, Shengxian Yuan, René Bernards, Haojie Jin, Wenxin Qin
Published 2023-01-01

Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors

by Vera E. van der Noord, Wanda van der Stel, Gijs Louwerens, Danielle Verhoeven, Hendrik J. Kuiken, Cor Lieftink, Melanie Grandits, Gerhard F. Ecker, Roderick L. Beijersbergen, Peter Bouwman, Sylvia E. Le Dévédec, Bob van de Water
Published 2023-05-01

Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer

by Yuchen Guo, Jun Wang, Bente Benedict, Chen Yang, Frank van Gemert, Xuhui Ma, Dongmei Gao, Hui Wang, Shu Zhang, Cor Lieftink, Roderick L. Beijersbergen, Hein te Riele, Xiaohang Qiao, Qiang Gao, Chong Sun, Wenxin Qin, René Bernards, Cun Wang
Published 2021-10-01

Parallel In Vivo and In Vitro Melanoma RNAi Dropout Screens Reveal Synthetic Lethality between Hypoxia and DNA Damage Response Inhibition

by Patricia A. Possik, Judith Müller, Carmen Gerlach, Juliana C.N. Kenski, Xinyao Huang, Aida Shahrabi, Oscar Krijgsman, Ji-Ying Song, Marjon A. Smit, Bram Gerritsen, Cor Lieftink, Kristel Kemper, Magali Michaut, Roderick L. Beijersbergen, Lodewyk Wessels, Ton N. Schumacher, Daniel S. Peeper
Published 2014-11-01

Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma

by Antonio Mulero‐Sánchez, Christel F. A. Ramirez, Aimée duChatinier, Hui Wang, Sofie J. I. Koomen, Ji‐Ying Song, Marnix H. P. deGroot, Cor Lieftink, Astrid Bosma, Artur Burylo, Olaf vanTellingen, Roderick L. Beijersbergen, Cun Wang, Leila Akkari, René Bernards, Sara Mainardi
Published 2023-06-01

Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3

by Chong Sun, Sebastijan Hobor, Andrea Bertotti, Davide Zecchin, Sidong Huang, Francesco Galimi, Francesca Cottino, Anirudh Prahallad, Wipawadee Grernrum, Anna Tzani, Andreas Schlicker, Lodewyk F.A. Wessels, Egbert F. Smit, Erik Thunnissen, Pasi Halonen, Cor Lieftink, Roderick L. Beijersbergen, Federica Di Nicolantonio, Alberto Bardelli, Livio Trusolino, Rene Bernards
Published 2014-04-01

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.

by Ziva Pogacar, Jackie L Johnson, Lenno Krenning, Giulia De Conti, Fleur Jochems, Cor Lieftink, Arno Velds, Leyma Wardak, Kelvin Groot, Arnout Schepers, Liqin Wang, Ji-Ying Song, Marieke van de Ven, Olaf van Tellingen, Rene H Medema, Roderick L Beijersbergen, Rene Bernards, Rodrigo Leite de Oliveira
Published 2022-01-01

Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer

by Joyce Y. Buikhuisen, Patricia M. Gomez Barila, Kate Cameron, Saskia J. E. Suijkerbuijk, Cor Lieftink, Simone di Franco, Ana Krotenberg Garcia, Rebeca Uceda Castro, Kristiaan J. Lenos, Lisanne E. Nijman, Arezo Torang, Ciro Longobardi, Joan H. de Jong, Daniëlle Dekker, Giorgio Stassi, Louis Vermeulen, Roderick L. Beijersbergen, Jacco van Rheenen, Stephan Huveneers, Jan Paul Medema
Published 2023-03-01