The Polycomb protein and E3 ubiquitin ligase Ring1B harbors an IRES in its highly conserved 5' UTR.

by Erwin Boutsma, Sonja Noback, Maarten van Lohuizen
Published 2008-06-01

SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes.

by Alexandre Prieur, Karim Nacerddine, Maarten van Lohuizen, Daniel S Peeper
Published 2009-01-01

A genome-wide enrichment screen identifies NUMA1-loss as a resistance mechanism against mitotic cell-death induced by BMI1 inhibition.

by Santiago Gisler, Ana Rita R Maia, Gayathri Chandrasekaran, Jawahar Kopparam, Maarten van Lohuizen
Published 2020-01-01

Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos.

by Bernd Schuettengruber, Mythily Ganapathi, Benjamin Leblanc, Manuela Portoso, Rami Jaschek, Bas Tolhuis, Maarten van Lohuizen, Amos Tanay, Giacomo Cavalli
Published 2009-01-01

Multiplexed Cas9 targeting reveals genomic location effects and gRNA-based staggered breaks influencing mutation efficiency

by Santiago Gisler, Joana P. Gonçalves, Waseem Akhtar, Johann de Jong, Alexey V. Pindyurin, Lodewyk F. A. Wessels, Maarten van Lohuizen
Published 2019-04-01

Interactions among Polycomb domains are guided by chromosome architecture.

by Bas Tolhuis, Marleen Blom, Ron M Kerkhoven, Ludo Pagie, Hans Teunissen, Marja Nieuwland, Marieke Simonis, Wouter de Laat, Maarten van Lohuizen, Bas van Steensel
Published 2011-03-01

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression

by Nienke A. de Vries, Danielle Hulsman, Waseem Akhtar, Johann de Jong, Denise C. Miles, Marleen Blom, Olaf van Tellingen, Jos Jonkers, Maarten van Lohuizen
Published 2015-01-01

Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.

by Petra van der Stoop, Erwin A Boutsma, Danielle Hulsman, Sonja Noback, Mike Heimerikx, Ron M Kerkhoven, J Willem Voncken, Lodewyk F A Wessels, Maarten van Lohuizen
Published 2008-05-01

Chromatin landscapes of retroviral and transposon integration profiles.

by Johann de Jong, Waseem Akhtar, Jitendra Badhai, Alistair G Rust, Roland Rad, John Hilkens, Anton Berns, Maarten van Lohuizen, Lodewyk F A Wessels, Jeroen de Ridder
Published 2014-04-01

Bmi1 Is Required for Hedgehog Pathway-Driven Medulloblastoma Expansion

by Lowell Evan Michael, Bart A. Westerman, Alexandre N. Ermilov, Aiqin Wang, Jennifer Ferris, Jianhong Liu, Marleen Blom, David W. Ellison, Maarten van Lohuizen, Andrzej A. Dlugosz
Published 2008-12-01

Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Eff...

by Martial Mbefo, Adeline Berger, Karine Schouwey, Xavier Gérard, Corinne Kostic, Avigail Beryozkin, Dror Sharon, Hélène Dolfuss, Francis Munier, Hoai Viet Tran, Maarten van Lohuizen, William A. Beltran, Yvan Arsenijevic
Published 2021-08-01

GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.

by Bart A Westerman, Marleen Blom, Ellen Tanger, Martin van der Valk, Ji-Ying Song, Marije van Santen, Jules Gadiot, Paulien Cornelissen-Steijger, John Zevenhoven, Haydn M Prosser, Anthony Uren, Eleonora Aronica, Maarten van Lohuizen
Published 2012-01-01

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

by Christiaan Klijn, Marco J Koudijs, Jaap Kool, Jelle ten Hoeve, Mandy Boer, Joost de Moes, Waseem Akhtar, Martine van Miltenburg, Annabel Vendel-Zwaagstra, Marcel J T Reinders, David J Adams, Maarten van Lohuizen, John Hilkens, Lodewyk F A Wessels, Jos Jonkers
Published 2013-01-01

Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer

by Leonie Ratz, Chiara Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, Ron D. Jachimowicz, Marieke van de Ven, Natalie Proost, Bjørn Siteur, Renske de Korte-Grimmerink, Peter Bouwman, Emilia M. Pulver, Roebi de Bruijn, Jörg Isensee, Tim Hucho, Gaurav Pandey, Maarten van Lohuizen, Peter Mallmann, Hans Christian Reinhardt, Jos Jonkers, Julian Puppe
Published 2022-06-01

Multiplexed Cas9 targeting reveals genomic location effects and gRNA-based staggered breaks influencing mutation efficiency

by Gisler, Santiago (author), P. Gonçalves, Joana (author), Akhtar, Waseem (author), de Jong, Johann (author), Pindyurin, Alexey V. (author), Wessels, L.F.A. (author), van Lohuizen, Maarten (author)
Published 2019

Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition

by Koppens, Martijn A.J. (author), Bounova, Gergana (author), Cornelissen-Steijger, Paulien (author), de Vries, Nienke (author), Sansom, Owen J. (author), Wessels, L.F.A. (author), van Lohuizen, Maarten (author)
Published 2016