The Landscape of Pediatric Precision Oncology: Program Design, Actionable Alterations, and Clinical Trial Development

by Karin P. S. Langenberg, Eleonora J. Looze, Jan J. Molenaar
Published 2021-08-01

DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.

by M Emmy M Dolman, Ida van der Ploeg, Jan Koster, Laurel Tabe Bate-Eya, Rogier Versteeg, Huib N Caron, Jan J Molenaar
Published 2015-01-01

Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

by Kaylee M. Keller, Thomas F. Eleveld, Linda Schild, Kim van den Handel, Marlinde van den Boogaard, Vicky Amo-Addae, Selma Eising, Kimberley Ober, Bianca Koopmans, Leendert Looijenga, Godelieve A.M. Tytgat, Bauke Ylstra, Jan J. Molenaar, Jan J. Molenaar, M. Emmy M. Dolman, M. Emmy M. Dolman, M. Emmy M. Dolman, Sander R. van Hooff
Published 2022-09-01

MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma

by Thomas F. Eleveld, Thomas F. Eleveld, Lindy Vernooij, Linda Schild, Bianca Koopmans, Lindy K. Alles, Marli E. Ebus, Rana Dandis, Harm van Tinteren, Huib N. Caron, Jan Koster, Max M. van Noesel, Godelieve A. M. Tytgat, Selma Eising, Rogier Versteeg, M. Emmy M. Dolman, M. Emmy M. Dolman, M. Emmy M. Dolman, Jan J. Molenaar, Jan J. Molenaar
Published 2023-02-01

Towards personalized therapy in pediatric acute lymphoblastic leukemia: RAS mutations and prednisolone resistance

by Ingrid M. Ariës, Rosanna E. van den Dungen, Marco J. Koudijs, Edwin Cuppen, Emile Voest, Jan J. Molenaar, Huib N. Caron, Rob Pieters, Monique L. den Boer
Published 2015-04-01

Decitabine mildly attenuates MLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer

by Pauline Schneider, Patricia Garrido Castro, Sandra M. Pinhanços, Mark Kerstjens, Eddy H. vanRoon, Anke H.W. Essing, M. Emmy M. Dolman, Jan J. Molenaar, Rob Pieters, Ronald W. Stam
Published 2020-11-01

P316: PRIORITIZING PRECISION MEDICINES IN PEDIATRIC BLOOD CANCER: EXPERIENCE OF THE DUTCH INDIVIDUALIZED THERAPY (ITHER) STUDY’S MOLECULAR TUMOR BOARD

by Judith M. Boer, Uri Ilan, Babette D.J. Hoen, Aurelie Boeree, Karin P.S. Langenberg, Jan Koster, Jean-Pierre Bourquin, Jan J. Molenaar, Bianca Goemans, Monique L. den Boer, Michel Zwaan
Published 2023-08-01

Preclinical assessment of combined BCL-2 and MCL-1 inhibition in high-risk neuroblastoma

by Lindy Vernooij, Alvin Kamili, Kimberley Ober, Jennemiek van Arkel, Lina Lankhorst, Enya Vermeulen, Hanin Al-Khakany, Gabor Tax, Marlinde L. van den Boogaard, Jamie I. Fletcher, Selma Eising, Jan J. Molenaar, M. Emmy M. Dolman
Published 2024-06-01

High-Throughput Drug Library Screening in Primary <i>KMT2A</i>-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling

by Priscilla Wander, Susan T. C. J. M. Arentsen-Peters, Kirsten S. Vrenken, Sandra Mimoso Pinhanҫos, Bianca Koopmans, M. Emmy M. Dolman, Luke Jones, Patricia Garrido Castro, Pauline Schneider, Mark Kerstjens, Jan J. Molenaar, Rob Pieters, Christian Michel Zwaan, Ronald W. Stam
Published 2022-03-01

αβ-T Cells Engineered to Express γδ-T Cell Receptors Can Kill Neuroblastoma Organoids Independent of MHC-I Expression

by Josephine G. M. Strijker, Ronja Pscheid, Esther Drent, Jessica J. F. van der Hoek, Bianca Koopmans, Kimberley Ober, Sander R. van Hooff, Waleed M. Kholosy, Annelisa M. Cornel, Chris Coomans, Andrea Bisso, Marleen M. van Loenen, Jan J. Molenaar, Judith Wienke
Published 2021-09-01

Neuroblastoma and DIPG Organoid Coculture System for Personalized Assessment of Novel Anticancer Immunotherapies

by Waleed M. Kholosy, Marc Derieppe, Femke van den Ham, Kim Ober, Yan Su, Lars Custers, Linda Schild, Lieke M. J. van Zogchel, Lianne M. Wellens, Hendrikus R. Ariese, Celina L. Szanto, Judith Wienke, Miranda P. Dierselhuis, Dannis van Vuurden, Emmy M. Dolman, Jan J. Molenaar
Published 2021-08-01

The clinical and biological characteristics of NUP98-KDM5A in pediatric acute myeloid leukemia

by Sanne Noort, Priscilla Wander, Todd A. Alonzo, Jenny Smith, Rhonda E. Ries, Robert B. Gerbing, M. Emmy M. Dolman, Franco Locatelli, Dirk Reinhardt, Andre Baruchel, Jan Stary, Jan J. Molenaar, Ronald W. Stam, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Soheil Meshinchi
Published 2020-05-01

High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia

by Priscilla Wander, Susan T.C.J.M. Arentsen-Peters, Sandra S. Pinhanҫos, Bianca Koopmans, M.Emmy M. Dolman, Rijndert Ariese, Frank L. Bos, Patricia Garrido Castro, Luke Jones, Pauline Schneider, Miriam Guillen Navarro, Jan J. Molenaar, Anne C. Rios, C. Michel Zwaan, Ronald W. Stam
Published 2021-05-01

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma

by Sally L George, Federica Lorenzi, David King, Sabine Hartlieb, James Campbell, Helen Pemberton, Umut H Toprak, Karen Barker, Jennifer Tall, Barbara Martins da Costa, Marlinde L van den Boogaard, M Emmy M Dolman, Jan J Molenaar, Helen E Bryant, Frank Westermann, Christopher J Lord, Louis Chesler
Published 2020-09-01

The potential of PARP as a therapeutic target across pediatric solid malignancies

by Kaylee M. Keller, Joost Koetsier, Linda Schild, Vicky Amo-Addae, Selma Eising, Kim van den Handel, Kimberley Ober, Bianca Koopmans, Anke Essing, Marlinde L. van den Boogaard, Karin P. S. Langenberg, Natalie Jäger, Marcel Kool, Stefan Pfister, M. Emmy M. Dolman, Jan J. Molenaar, Sander R. van Hooff
Published 2023-04-01

Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors

by Camilla Calandrini, Sander R. van Hooff, Irene Paassen, Dilara Ayyildiz, Sepide Derakhshan, M. Emmy M. Dolman, Karin P.S. Langenberg, Marieke van de Ven, Cecilia de Heus, Nalan Liv, Marcel Kool, Ronald R. de Krijger, Godelieve A.M. Tytgat, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Jarno Drost
Published 2021-08-01

G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment

by Taco W Kuijpers, Timo K van den Berg, Paula Martinez Sanz, Dieke J van Rees, Lieke M J van Zogchel, Bart Klein, Panagiota Bouti, Hugo Olsman, Karin Schornagel, Ivana Kok, Ali Sunak, Kira Leeuwenburg, Ilse Timmerman, Miranda P Dierselhuis, Waleed M Kholosy, Jan J Molenaar, Robin van Bruggen, Hanke L Matlung, Godelieve A M Tytgat, Katka Franke
Published 2021-05-01

Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS

by Ianthe A. E. M. van Belzen, Casey Cai, Marc van Tuil, Shashi Badloe, Eric Strengman, Alex Janse, Eugène T. P. Verwiel, Douwe F. M. van der Leest, Lennart Kester, Jan J. Molenaar, Jules Meijerink, Jarno Drost, Weng Chuan Peng, Hindrik H. D. Kerstens, Bastiaan B. J. Tops, Frank C. P. Holstege, Patrick Kemmeren, Jayne Y. Hehir-Kwa
Published 2023-07-01

Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch

by Judith Wienke, S Nierkens, Miranda P Dierselhuis, Jan J Molenaar, Annelisa M Cornel, Ester Dunnebach, Damon A Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Josephine G M Strijker, Denise A M H van den Beemt, Anke H W Essing, Bianca Koopmans, Sem A G Engels, Vania Lo Presti, Celina S Szanto, Rani E George, Sebastiaan van Heesch
Published 2022-12-01

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

by Bieke Decaesteker, Geertrui Denecker, Christophe Van Neste, Emmy M. Dolman, Wouter Van Loocke, Moritz Gartlgruber, Carolina Nunes, Fanny De Vloed, Pauline Depuydt, Karen Verboom, Dries Rombaut, Siebe Loontiens, Jolien De Wyn, Waleed M. Kholosy, Bianca Koopmans, Anke H. W. Essing, Carl Herrmann, Daniel Dreidax, Kaat Durinck, Dieter Deforce, Filip Van Nieuwerburgh, Anton Henssen, Rogier Versteeg, Valentina Boeva, Gudrun Schleiermacher, Johan van Nes, Pieter Mestdagh, Suzanne Vanhauwaert, Johannes H. Schulte, Frank Westermann, Jan J. Molenaar, Katleen De Preter, Frank Speleman
Published 2018-11-01