P342: RAS PATHWAY ACTIVATION REMODELS THE BONE MARROW MICROENVIRONMENT IN ACUTE LYMPHOBLASTIC LEUKAEMIA

by Mauricio Ferrao Blanco, Lennart Kester, Jayne Hehir-Kwa, Monique den Boer, Olaf Heidenreich, Josef Vormoor
Published 2023-08-01

Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta

by Chloé S. Baron, Lennart Kester, Anna Klaus, Jean-Charles Boisset, Roshana Thambyrajah, Laurent Yvernogeau, Valérie Kouskoff, Georges Lacaud, Alexander van Oudenaarden, Catherine Robin
Published 2018-06-01

Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche

by Shilu Amin, Roel Neijts, Salvatore Simmini, Carina van Rooijen, Sander C. Tan, Lennart Kester, Alexander van Oudenaarden, Menno P. Creyghton, Jacqueline Deschamps
Published 2016-12-01

Integration of multiple lineage measurements from the same cell reconstructs parallel tumor evolution

by Lennart Kester, Buys de Barbanson, Anna Lyubimova, Li-Ting Chen, Valérie van der Schrier, Anna Alemany, Dylan Mooijman, Josi Peterson-Maduro, Jarno Drost, Jeroen de Ridder, Alexander van Oudenaarden
Published 2022-02-01

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

by Evelyne Beerling, Daniëlle Seinstra, Elzo de Wit, Lennart Kester, Daphne van der Velden, Carrie Maynard, Ronny Schäfer, Paul van Diest, Emile Voest, Alexander van Oudenaarden, Nienke Vrisekoop, Jacco van Rheenen
Published 2016-03-01

Malignant glioma in L-2-Hydroxy Glutaric Aciduria: thorough molecular characterization of a case and literature review

by Fleur Cordier, Pieter Wesseling, Bastiaan B.J. Tops, Lennart Kester, Pim J. French, Martin van den Bent, Felix Hinz, Eleonora Aronica, K. Mariam Slot, Floor Abbink, Marjo S. van der Knaap, Mariette Kranendonk
Published 2024-05-01

Epithelial-to-Mesenchymal Transition Drives Invasiveness of Breast Cancer Brain Metastases

by Andreia S. Margarido, Rebeca Uceda-Castro, Kerstin Hahn, Roebi de Bruijn, Lennart Kester, Ingrid Hofland, Jeroen Lohuis, Danielle Seinstra, Annegien Broeks, Jos Jonkers, Marike L. D. Broekman, Pieter Wesseling, Claire Vennin, Miguel Vizoso, Jacco van Rheenen
Published 2022-06-01

Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS

by Ianthe A. E. M. van Belzen, Casey Cai, Marc van Tuil, Shashi Badloe, Eric Strengman, Alex Janse, Eugène T. P. Verwiel, Douwe F. M. van der Leest, Lennart Kester, Jan J. Molenaar, Jules Meijerink, Jarno Drost, Weng Chuan Peng, Hindrik H. D. Kerstens, Bastiaan B. J. Tops, Frank C. P. Holstege, Patrick Kemmeren, Jayne Y. Hehir-Kwa
Published 2023-07-01

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

by Cindy J.M. Loomans, Nerys Williams Giuliani, Jeetindra Balak, Femke Ringnalda, Léon van Gurp, Meritxell Huch, Sylvia F. Boj, Toshiro Sato, Lennart Kester, Susana M. Chuva de Sousa Lopes, Matthias S. Roost, Susan Bonner-Weir, Marten A. Engelse, Ton J. Rabelink, Harry Heimberg, Robert G.J. Vries, Alexander van Oudenaarden, Françoise Carlotti, Hans Clevers, Eelco J.P. de Koning
Published 2018-03-01