Integrating pathology into human disease modelling – how to eat the elephant

by Cheryl L. Scudamore
Published 2014-05-01

Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?

by Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L Scudamore, Alan R Prescott, Philip Cohen
Published 2022-01-01

Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?

by Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L. Scudamore, Alan R. Prescott, Philip Cohen
Published 2022-01-01

Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.

by Amany K Elshorbagy, Fredrik Jernerén, Cheryl L Scudamore, Fiona McMurray, Heather Cater, Tertius Hough, Roger Cox, Helga Refsum
Published 2016-01-01

Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice

by Natalie Brown, Rosemary Finnon, Paul Finnon, Roisin McCarron, Lourdes Cruz-Garcia, Grainne O’Brien, Eleanor Herbert, Cheryl L. Scudamore, Edouard Morel, Christophe Badie
Published 2023-09-01

Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues

by Ahmed Al-Jazzar, Behzad Javaheri, Matt Prideaux, Alan Boyde, Cheryl L. Scudamore, Chahrazad Cherifi, Eric Hay, Mark Hopkinson, Michael Boyd, Martine Cohen-Solal, Colin Farquharson, Andrew A. Pitsillides
Published 2016-12-01

Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance

by Alison J. Hugill, Michelle E. Stewart, Marianne A. Yon, Fay Probert, I. Jane Cox, Tertius A. Hough, Cheryl L. Scudamore, Liz Bentley, Gary Wall, Sara E. Wells, Roger D. Cox
Published 2015-11-01

Pharmacological inhibition of FTO.

by Fiona McMurray, Marina Demetriades, WeiShen Aik, Myrte Merkestein, Holger Kramer, Daniel S Andrew, Cheryl L Scudamore, Tertius A Hough, Sara Wells, Frances M Ashcroft, Michael A McDonough, Christopher J Schofield, Roger D Cox
Published 2015-01-01

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

by Samira Alliouachene, Benoit Bilanges, Gaëtan Chicanne, Karen E. Anderson, Wayne Pearce, Khaled Ali, Colin Valet, York Posor, Pei Ching Low, Claire Chaussade, Cheryl L. Scudamore, Rachel S. Salamon, Jonathan M. Backer, Len Stephens, Phill T. Hawkins, Bernard Payrastre, Bart Vanhaesebroeck
Published 2015-12-01

Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors

by Paris Kosti, James W. Opzoomer, Karen I. Larios-Martinez, Rhonda Henley-Smith, Cheryl L. Scudamore, Mary Okesola, Mustafa Y.M. Taher, David M. Davies, Tamara Muliaditan, Daniel Larcombe-Young, Natalie Woodman, Cheryl E. Gillett, Selvam Thavaraj, John Maher, James N. Arnold
Published 2021-04-01

The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities.

by Eleanor Herbert, Michelle Stewart, Marie Hutchison, Ann M Flenniken, Dawei Qu, Lauryl M J Nutter, Colin McKerlie, Liane Hobson, Brenda Kick, Bonnie Lyons, Jean-Paul Wiegand, Rosalinda Doty, Juan Antonio Aguilar-Pimentel, Martin Hrabe de Angelis, Mary Dickinson, John Seavitt, Jacqueline K White, Cheryl L Scudamore, Sara Wells
Published 2020-01-01

Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

by Simon Maguire, Jeanne Estabel, Neil Ingham, Selina Pearson, Edward Ryder, Damian M Carragher, Nicolas Walker, Sanger MGP Slc25a21 Project Team, James Bussell, Wai-In Chan, Thomas M Keane, David J Adams, Cheryl L Scudamore, Christopher J Lelliott, Ramiro Ramírez-Solis, Natasha A Karp, Karen P Steel, Jacqueline K White, Anna-Karin Gerdin
Published 2014-01-01

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

by Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo, Wayne Pearce, Nicholas McGranahan, Sally M. Dewhurst, Valerie Meniel, Nicolai J. Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria E. R. Parker, Karen G. Montgomery, Larissa S. Moniz, Cheryl L. Scudamore, Wayne A. Phillips, Robert K. Semple, Alan Clarke, Charles Swanton, Bart Vanhaesebroeck
Published 2017-11-01

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

by Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaëtan Chicanne, Colin Valet, Julia M. Hill, Peter J. Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Rachel S. Salamon, Jonathan M. Backer, Cheryl L. Scudamore, Maria A. Whitehead, Erin P. Keaney, Leon O. Murphy, Robert K. Semple, Bernard Payrastre, Sharon A. Tooze, Bart Vanhaesebroeck
Published 2017-11-01

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

by Eva Lana-Elola, Heather Cater, Sheona Watson-Scales, Simon Greenaway, Jennifer Müller-Winkler, Dorota Gibbins, Mihaela Nemes, Amy Slender, Tertius Hough, Piia Keskivali-Bond, Cheryl L. Scudamore, Eleanor Herbert, Gareth T. Banks, Helene Mobbs, Tara Canonica, Justin Tosh, Suzanna Noy, Miriam Llorian, Patrick M. Nolan, Julian L. Griffin, Mark Good, Michelle Simon, Ann-Marie Mallon, Sara Wells, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz
Published 2021-10-01

Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

by Rebecca E McIntyre, Pavithra Lakshminarasimhan Chavali, Ozama Ismail, Damian M Carragher, Gabriela Sanchez-Andrade, Josep V Forment, Beiyuan Fu, Martin Del Castillo Velasco-Herrera, Andrew Edwards, Louise van der Weyden, Fengtang Yang, Sanger Mouse Genetics Project, Ramiro Ramirez-Solis, Jeanne Estabel, Ferdia A Gallagher, Darren W Logan, Mark J Arends, Stephen H Tsang, Vinit B Mahajan, Cheryl L Scudamore, Jacqueline K White, Stephen P Jackson, Fanni Gergely, David J Adams
Published 2012-01-01

Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare.

by Gail F Davies, Beth J Greenhough, Pru Hobson-West, Robert G W Kirk, Ken Applebee, Laura C Bellingan, Manuel Berdoy, Henry Buller, Helen J Cassaday, Keith Davies, Daniela Diefenbacher, Tone Druglitrø, Maria Paula Escobar, Carrie Friese, Kathrin Herrmann, Amy Hinterberger, Wendy J Jarrett, Kimberley Jayne, Adam M Johnson, Elizabeth R Johnson, Timm Konold, Matthew C Leach, Sabina Leonelli, David I Lewis, Elliot J Lilley, Emma R Longridge, Carmen M McLeod, Mara Miele, Nicole C Nelson, Elisabeth H Ormandy, Helen Pallett, Lonneke Poort, Pandora Pound, Edmund Ramsden, Emma Roe, Helen Scalway, Astrid Schrader, Chris J Scotton, Cheryl L Scudamore, Jane A Smith, Lucy Whitfield, Sarah Wolfensohn
Published 2016-01-01