Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution

by Kerstin Thol, Piotr Pawlik, Nicholas McGranahan
Published 2022-12-01

Germline ancestry influences the evolutionary disease course in lung adenocarcinomas

by Alina Schenk, Saioa López, Maik Kschischo, Nicholas McGranahan
Published 2020-08-01

Computational Analysis Reveals the Temporal Acquisition of Pathway Alterations during the Evolution of Cancer

by Johanne Ahrenfeldt, Ditte S. Christensen, Mateo Sokač, Judit Kisistók, Nicholas McGranahan, Nicolai J. Birkbak
Published 2022-11-01

Tracking the evolution of esophageal squamous cell carcinoma under dynamic immune selection by multi-omics sequencing

by Sijia Cui, Nicholas McGranahan, Jing Gao, Peng Chen, Wei Jiang, Lingrong Yang, Li Ma, Junfang Liao, Tian Xie, Congying Xie, Tariq Enver, Shixiu Wu
Published 2023-02-01

Phenotyping of lymphoproliferative tumours generated in xenografts of non-small cell lung cancer

by David R. Pearce, David R. Pearce, Ayse U. Akarca, Roel P. H. De Maeyer, Emily Kostina, Ariana Huebner, Ariana Huebner, Ariana Huebner, Monica Sivakumar, Monica Sivakumar, Takahiro Karasaki, Kavina Shah, Sam M. Janes, Nicholas McGranahan, Nicholas McGranahan, Venkat Reddy, Arne N. Akbar, David A. Moore, David A. Moore, Teresa Marafioti, Charles Swanton, Charles Swanton, Robert E. Hynds, Robert E. Hynds, Robert E. Hynds
Published 2023-06-01

Plk1 overexpression induces chromosomal instability and suppresses tumor development

by Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañés, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres, Rocío Sotillo
Published 2018-08-01

Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity.

by Thomas B K Watkins, Emma C Colliver, Matthew R Huska, Tom L Kaufmann, Emilia L Lim, Cody B Duncan, Kerstin Haase, Peter Van Loo, Charles Swanton, Nicholas McGranahan, Roland F Schwarz
Published 2023-10-01

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

by Oliver J. Ziff, Jacob Neeves, Jamie Mitchell, Giulia Tyzack, Carlos Martinez-Ruiz, Raphaelle Luisier, Anob M. Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J. Boulton, Ammar Al-Chalabi, Gavin Kelly, Jack Humphrey, Rickie Patani
Published 2023-04-01

ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA

by Ariana Huebner, James R. M. Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A. Toledo
Published 2023-04-01

Neoantigen-reactive CD8+ T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma

by Nikolaj Pagh Kristensen, Christina Heeke, Siri A. Tvingsholm, Annie Borch, Arianna Draghi, Michael D. Crowther, Ibel Carri, Kamilla K. Munk, Jeppe Sejerø Holm, Anne-Mette Bjerregaard, Amalie Kai Bentzen, Andrea M. Marquard, Zoltan Szallasi, Nicholas McGranahan, Rikke Andersen, Morten Nielsen, Göran B. Jönsson, Marco Donia, Inge Marie Svane, Sine Reker Hadrup
Published 2022-01-01

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

by Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo, Wayne Pearce, Nicholas McGranahan, Sally M. Dewhurst, Valerie Meniel, Nicolai J. Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria E. R. Parker, Karen G. Montgomery, Larissa S. Moniz, Cheryl L. Scudamore, Wayne A. Phillips, Robert K. Semple, Alan Clarke, Charles Swanton, Bart Vanhaesebroeck
Published 2017-11-01

Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer

by Filipe Correia Martins, Dominique-Laurent Couturier, Ines de Santiago, Carolin Margarethe Sauer, Maria Vias, Mihaela Angelova, Deborah Sanders, Anna Piskorz, James Hall, Karen Hosking, Anumithra Amirthanayagam, Sabina Cosulich, Larissa Carnevalli, Barry Davies, Thomas B. K. Watkins, Ionut G. Funingana, Helen Bolton, Krishnayan Haldar, John Latimer, Peter Baldwin, Robin Crawford, Matthew Eldridge, Bristi Basu, Mercedes Jimenez-Linan, Andrew W. Mcpherson, Nicholas McGranahan, Kevin Litchfield, Sohrab P. Shah, Iain McNeish, Carlos Caldas, Gerard Evan, Charles Swanton, James D. Brenton
Published 2022-10-01

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

by Xin Hu, Marcos R. Estecio, Runzhe Chen, Alexandre Reuben, Linghua Wang, Junya Fujimoto, Jian Carrot-Zhang, Nicholas McGranahan, Lisha Ying, Junya Fukuoka, Chi-Wan Chow, Hoa H. N. Pham, Myrna C. B. Godoy, Brett W. Carter, Carmen Behrens, Jianhua Zhang, Mara B. Antonoff, Boris Sepesi, Yue Lu, Harvey I. Pass, Humam Kadara, Paul Scheet, Ara A. Vaporciyan, John V. Heymach, Ignacio I. Wistuba, J. Jack Lee, P. Andrew Futreal, Dan Su, Jean-Pierre J. Issa, Jianjun Zhang
Published 2021-01-01

MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically

by Enkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina S. P. Poh, Xin Wang, Stefan Fröhling, Katja Steiger, Julia Slotta-Huspenina, Martijn van Griensven, Franz Pfeiffer, Sebastian Lange, Roland Rad, Magda Spella, Georgios T. Stathopoulos, Jürgen Ruland, Florian Bassermann, Wilko Weichert, Andreas Strasser, Caterina Branca, Mathias Heikenwalder, Charles Swanton, Nicholas McGranahan, Philipp J. Jost
Published 2020-09-01

Identifying key questions in the ecology and evolution of cancer

by Antoine M. Dujon, Athena Aktipis, Catherine Alix‐Panabières, Sarah R. Amend, Amy M. Boddy, Joel S. Brown, Jean‐Pascal Capp, James DeGregori, Paul Ewald, Robert Gatenby, Marco Gerlinger, Mathieu Giraudeau, Rodrigo K. Hamede, Elsa Hansen, Irina Kareva, Carlo C. Maley, Andriy Marusyk, Nicholas McGranahan, Michael J. Metzger, Aurora M. Nedelcu, Robert Noble, Leonard Nunney, Kenneth J. Pienta, Kornelia Polyak, Pascal Pujol, Andrew F. Read, Benjamin Roche, Susanne Sebens, Eric Solary, Kateřina Staňková, Holly Swain Ewald, Frédéric Thomas, Beata Ujvari
Published 2021-04-01

Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models

by Robert E. Hynds, Ariana Huebner, David R. Pearce, Mark S. Hill, Ayse U. Akarca, David A. Moore, Sophia Ward, Kate H. C. Gowers, Takahiro Karasaki, Maise Al Bakir, Gareth A. Wilson, Oriol Pich, Carlos Martínez-Ruiz, A. S. Md Mukarram Hossain, Simon P. Pearce, Monica Sivakumar, Assma Ben Aissa, Eva Grönroos, Deepak Chandrasekharan, Krishna K. Kolluri, Rebecca Towns, Kaiwen Wang, Daniel E. Cook, Leticia Bosshard-Carter, Cristina Naceur-Lombardelli, Andrew J. Rowan, Selvaraju Veeriah, Kevin Litchfield, Philip A. J. Crosbie, Caroline Dive, Sergio A. Quezada, Sam M. Janes, Mariam Jamal-Hanjani, Teresa Marafioti, TRACERx consortium, Nicholas McGranahan, Charles Swanton
Published 2024-05-01

Author Correction: Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

by Xin Hu, Junya Fujimoto, Lisha Ying, Junya Fukuoka, Kazuto Ashizawa, Wenyong Sun, Alexandre Reuben, Chi-Wan Chow, Nicholas McGranahan, Runzhe Chen, Jinlin Hu, Myrna C. Godoy, Kazuhiro Tabata, Kishio Kuroda, Lei Shi, Jun Li, Carmen Behrens, Edwin Roger Parra, Latasha D. Little, Curtis Gumbs, Xizeng Mao, Xingzhi Song, Samantha Tippen, Rebecca L. Thornton, Humam Kadara, Paul Scheet, Emily Roarty, Edwin Justin Ostrin, Xu Wang, Brett W. Carter, Mara B. Antonoff, Jianhua Zhang, Ara A. Vaporciyan, Harvey Pass, Stephen G. Swisher, John V. Heymach, J. Jack Lee, Ignacio I. Wistuba, Waun Ki Hong, P. Andrew Futreal, Dan Su, Jianjun Zhang
Published 2021-05-01

Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

by Xin Hu, Junya Fujimoto, Lisha Ying, Junya Fukuoka, Kazuto Ashizawa, Wenyong Sun, Alexandre Reuben, Chi-Wan Chow, Nicholas McGranahan, Runzhe Chen, Jinlin Hu, Myrna C. Godoy, Kazuhiro Tabata, Kishio Kuroda, Lei Shi, Jun Li, Carmen Behrens, Edwin Roger Parra, Latasha D. Little, Curtis Gumbs, Xizeng Mao, Xingzhi Song, Samantha Tippen, Rebecca L. Thornton, Humam Kadara, Paul Scheet, Emily Roarty, Edwin Justin Ostrin, Xu Wang, Brett W. Carter, Mara B. Antonoff, Jianhua Zhang, Ara A. Vaporciyan, Harvey Pass, Stephen G. Swisher, John V. Heymach, J. Jack Lee, Ignacio I. Wistuba, Waun Ki Hong, P. Andrew Futreal, Dan Su, Jianjun Zhang
Published 2019-07-01

Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer

by Ming Chen, Runzhe Chen, Ying Jin, Jun Li, Xin Hu, Jiexin Zhang, Junya Fujimoto, Shawna M. Hubert, Carl M. Gay, Bo Zhu, Yanhua Tian, Nicholas McGranahan, Won-Chul Lee, Julie George, Xiao Hu, Yamei Chen, Meijuan Wu, Carmen Behrens, Chi-Wan Chow, Hoa H. N. Pham, Junya Fukuoka, Jia Wu, Edwin Roger Parra, Latasha D. Little, Curtis Gumbs, Xingzhi Song, Chang-Jiun Wu, Lixia Diao, Qi Wang, Robert Cardnell, Jianhua Zhang, Jing Wang, Xiuning Le, Don L. Gibbons, John V. Heymach, J. Jack Lee, William N. William, Chao Cheng, Bonnie Glisson, Ignacio Wistuba, P. Andrew Futreal, Roman K. Thomas, Alexandre Reuben, Lauren A. Byers, Jianjun Zhang
Published 2021-11-01

Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity

by Won-Chul Lee, Alexandre Reuben, Xin Hu, Nicholas McGranahan, Runzhe Chen, Ali Jalali, Marcelo V. Negrao, Shawna M. Hubert, Chad Tang, Chia-Chin Wu, Anthony San Lucas, Whijae Roh, Kenichi Suda, Jihye Kim, Aik-Choon Tan, David H. Peng, Wei Lu, Ximing Tang, Chi-Wan Chow, Junya Fujimoto, Carmen Behrens, Neda Kalhor, Kazutaka Fukumura, Marcus Coyle, Rebecca Thornton, Curtis Gumbs, Jun Li, Chang-Jiun Wu, Latasha Little, Emily Roarty, Xingzhi Song, J. Jack Lee, Erik P. Sulman, Ganesh Rao, Stephen Swisher, Lixia Diao, Jing Wang, John V. Heymach, Jason T. Huse, Paul Scheet, Ignacio I. Wistuba, Don L. Gibbons, P. Andrew Futreal, Jianhua Zhang, Daniel Gomez, Jianjun Zhang
Published 2020-11-01