Ubiquitylation, neddylation and the DNA damage response

by Jessica S. Brown, Stephen P. Jackson
Published 2015-01-01

Clinical prospects of WRN inhibition as a treatment for MSI tumours

by David A. Morales-Juarez, Stephen P. Jackson
Published 2022-11-01

Myocardial Fibrosis in Heart Failure: Anti-Fibrotic Therapies and the Role of Cardiovascular Magnetic Resonance in Drug Trials

by Matthew Webber, Stephen P. Jackson, James C. Moon, Gabriella Captur
Published 2020-08-01

Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.

by Josep V Forment, Melanie Blasius, Ilaria Guerini, Stephen P Jackson
Published 2011-01-01

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

by Pauline Chanut, Sébastien Britton, Julia Coates, Stephen P. Jackson, Patrick Calsou
Published 2016-09-01

Correction: Corrigendum: Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

by Pauline Chanut, Sébastien Britton, Julia Coates, Stephen P. Jackson, Patrick Calsou
Published 2017-06-01

Validating the concept of mutational signatures with isogenic cell models

by Xueqing Zou, Michel Owusu, Rebecca Harris, Stephen P. Jackson, Joanna I. Loizou, Serena Nik-Zainal
Published 2018-05-01

CtIP Mutations Cause Seckel and Jawad Syndromes.

by Per Qvist, Pablo Huertas, Sonia Jimeno, Mette Nyegaard, Muhammad J Hassan, Stephen P Jackson, Anders D Børglum
Published 2011-10-01

PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

by Rimma Belotserkovskaya, Elisenda Raga Gil, Nicola Lawrence, Richard Butler, Gillian Clifford, Marcus D. Wilson, Stephen P. Jackson
Published 2020-02-01

MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

by Israel Salguero, Rimma Belotserkovskaya, Julia Coates, Matylda Sczaniecka-Clift, Mukerrem Demir, Satpal Jhujh, Marcus D. Wilson, Stephen P. Jackson
Published 2019-11-01

Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

by Jessica S. Brown, Natalia Lukashchuk, Matylda Sczaniecka-Clift, Sébastien Britton, Carlos le Sage, Patrick Calsou, Petra Beli, Yaron Galanty, Stephen P. Jackson
Published 2015-05-01

Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance

by Anne Ramsay Bowden, David A Morales-Juarez, Matylda Sczaniecka-Clift, Maria Martin Agudo, Natalia Lukashchuk, John Christopher Thomas, Stephen P Jackson
Published 2020-05-01

Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma.

by Sonja J Gill, Jon Travers, Irina Pshenichnaya, Fiona A Kogera, Syd Barthorpe, Tatiana Mironenko, Laura Richardson, Cyril H Benes, Michael R Stratton, Ultan McDermott, Stephen P Jackson, Mathew J Garnett
Published 2015-01-01

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

by Chloé Lescale, Hélène Lenden Hasse, Andrew N. Blackford, Gabriel Balmus, Joy J. Bianchi, Wei Yu, Léa Bacoccina, Angélique Jarade, Christophe Clouin, Rohan Sivapalan, Bernardo Reina-San-Martin, Stephen P. Jackson, Ludovic Deriano
Published 2016-09-01

SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination

by Estelle Vincendeau, Wenming Wei, Xuefei Zhang, Cyril Planchais, Wei Yu, Hélène Lenden-Hasse, Thomas Cokelaer, Juliana Pipoli da Fonseca, Hugo Mouquet, David J. Adams, Frederick W. Alt, Stephen P. Jackson, Gabriel Balmus, Chloé Lescale, Ludovic Deriano
Published 2022-06-01

Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

by Martin Moder, Georgia Velimezi, Michel Owusu, Abdelghani Mazouzi, Marc Wiedner, Joana Ferreira da Silva, Lydia Robinson-Garcia, Fiorella Schischlik, Rastislav Slavkovsky, Robert Kralovics, Michael Schuster, Christoph Bock, Trey Ideker, Stephen P. Jackson, Jörg Menche, Joanna I. Loizou
Published 2017-11-01

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

by Georgia Velimezi, Lydia Robinson-Garcia, Francisco Muñoz-Martínez, Wouter W. Wiegant, Joana Ferreira da Silva, Michel Owusu, Martin Moder, Marc Wiedner, Sara Brin Rosenthal, Kathleen M. Fisch, Jason Moffat, Jörg Menche, Haico van Attikum, Stephen P. Jackson, Joanna I. Loizou
Published 2018-06-01

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

by Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson
Published 2018-04-01

Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model

by Tracy-Shi Zhang Fang, Yu Sun, Andrew C. Pearce, Simona Eleuteri, Mark Kemp, Christopher A. Luckhurst, Rachel Williams, Ross Mills, Sarah Almond, Laura Burzynski, Nóra M. Márkus, Christopher J. Lelliott, Natasha A. Karp, David J. Adams, Stephen P. Jackson, Jin-Feng Zhao, Ian G. Ganley, Paul W. Thompson, Gabriel Balmus, David K. Simon
Published 2023-11-01

Combinatorial CRISPR screen identifies fitness effects of gene paralogues

by Nicola A. Thompson, Marco Ranzani, Louise van der Weyden, Vivek Iyer, Victoria Offord, Alastair Droop, Fiona Behan, Emanuel Gonçalves, Anneliese Speak, Francesco Iorio, James Hewinson, Victoria Harle, Holly Robertson, Elizabeth Anderson, Beiyuan Fu, Fengtang Yang, Guido Zagnoli-Vieira, Phil Chapman, Martin Del Castillo Velasco-Herrera, Mathew J. Garnett, Stephen P. Jackson, David J. Adams
Published 2021-02-01