RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination

by Leo Kiss, Dean Clift, Nadine Renner, David Neuhaus, Leo C. James
Published 2021-02-01

TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing

by Jakub Luptak, Donna L. Mallery, Aminu S. Jahun, Anna Albecka, Dean Clift, Osaid Ather, Greg Slodkowicz, Ian Goodfellow, Leo C. James
Published 2022-07-01

Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere

by Kitty F Verzijlbergen, Olga O Nerusheva, David Kelly, Alastair Kerr, Dean Clift, Flavia de Lima Alves, Juri Rappsilber, Adele L Marston
Published 2014-02-01

Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates

by Leo Kiss, Tyler Rhinesmith, Jakub Luptak, Claire F. Dickson, Jonas Weidenhausen, Shannon Smyly, Ji-Chun Yang, Sarah L. Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C. James
Published 2023-04-01

A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation

by Alice Fletcher, Dean Clift, Emma de Vries, Sergio Martinez Cuesta, Timothy Malcolm, Francesco Meghini, Raghothama Chaerkady, Junmin Wang, Abby Chiang, Shao Huan Samuel Weng, Jonathan Tart, Edmond Wong, Gerard Donohoe, Philip Rawlins, Euan Gordon, Jonathan D. Taylor, Leo James, James Hunt
Published 2023-11-01

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

by Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson
Published 2018-04-01