Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability

by Bart Vanhaesebroeck, Benoit Bilanges, Ralitsa R. Madsen, Katie L. Dale, Evelyn Lau, Elina Vladimirou
Published 2019-08-01

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation

by Chih-Yao Chung, Kritarth Singh, Vassilios N. Kotiadis, Gabriel E. Valdebenito, Jee Hwan Ahn, Emilie Topley, Joycelyn Tan, William D. Andrews, Benoit Bilanges, Robert D. S. Pitceathly, Gyorgy Szabadkai, Mariia Yuneva, Michael R. Duchen
Published 2021-11-01

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

by Samira Alliouachene, Benoit Bilanges, Gaëtan Chicanne, Karen E. Anderson, Wayne Pearce, Khaled Ali, Colin Valet, York Posor, Pei Ching Low, Claire Chaussade, Cheryl L. Scudamore, Rachel S. Salamon, Jonathan M. Backer, Len Stephens, Phill T. Hawkins, Bernard Payrastre, Bart Vanhaesebroeck
Published 2015-12-01

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

by Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaëtan Chicanne, Colin Valet, Julia M. Hill, Peter J. Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Rachel S. Salamon, Jonathan M. Backer, Cheryl L. Scudamore, Maria A. Whitehead, Erin P. Keaney, Leon O. Murphy, Robert K. Semple, Bernard Payrastre, Sharon A. Tooze, Bart Vanhaesebroeck
Published 2017-11-01