Mucosal Immunity and Protective Efficacy of Intranasal Inactivated Influenza Vaccine Is Improved by Chitosan Nanoparticle Delivery in Pigs

by Santosh Dhakal, Sankar Renu, Shristi Ghimire, Yashavanth Shaan Lakshmanappa, Bradley T. Hogshead, Ninoshkaly Feliciano-Ruiz, Fangjia Lu, Harm HogenEsch, Steven Krakowka, Chang Won Lee, Gourapura J. Renukaradhya
Published 2018-05-01

Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection

by Chase E. Hawes, Sonny R. Elizaldi, Danielle Beckman, Giovanne B. Diniz, Yashavanth Shaan Lakshmanappa, Sean Ott, Blythe P. Durbin-Johnson, Ashok R. Dinasarapu, Andrea Gompers, John H. Morrison, Smita S. Iyer
Published 2022-10-01

Gut Microbiota of Obese Children Influences Inflammatory Mucosal Immune Pathways in the Respiratory Tract to Influenza Virus Infection: Optimization of an Ideal Duration of Microbi...

by Sankar Renu, Loic Deblais, Veerupaxagouda Patil, Jennifer Schrock, Dipak Kathayat, Vishal Srivastava, Ninoshkaly Feliciano-Ruiz, Yi Han, Anikethana Ramesh, Yashavanth S. Lakshmanappa, Shristi Ghimire, Santosh Dhakal, Gireesh Rajashekara, Gourapura J. Renukaradhya
Published 2022-06-01

Amish (Rural) vs. non-Amish (Urban) Infant Fecal Microbiotas Are Highly Diverse and Their Transplantation Lead to Differences in Mucosal Immune Maturation in a Humanized Germfree P...

by Santosh Dhakal, Santosh Dhakal, Lingling Wang, Linto Antony, Jennifer Rank, Jennifer Rank, Pauline Bernardo, Pauline Bernardo, Shristi Ghimire, Shristi Ghimire, Kathy Bondra, Kathy Bondra, Christina Siems, Christina Siems, Yashavanth Shaan Lakshmanappa, Yashavanth Shaan Lakshmanappa, Sankar Renu, Sankar Renu, Bradley Hogshead, Bradley Hogshead, Steven Krakowka, Mike Kauffman, Mike Kauffman, Joy Scaria, Jeffrey T. LeJeune, Jeffrey T. LeJeune, Zhongtang Yu, Gourapura J. Renukaradhya, Gourapura J. Renukaradhya
Published 2019-07-01

Deep analysis of CD4 T cells in the rhesus CNS during SIV infection.

by Sonny R Elizaldi, Anil Verma, Zhong-Min Ma, Sean Ott, Dhivyaa Rajasundaram, Chase E Hawes, Yashavanth Shaan Lakshmanappa, Mackenzie L Cottrell, Angela D M Kashuba, Zandrea Ambrose, Jeffrey D Lifson, John H Morrison, Smita S Iyer
Published 2023-12-01

Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation

by Anil Verma, Chase E. Hawes, Yashavanth Shaan Lakshmanappa, Jamin W. Roh, Brian A. Schmidt, Joseph Dutra, William Louie, Hongwei Liu, Zhong-Min Ma, Jennifer K. Watanabe, Jodie L. Usachenko, Ramya Immareddy, Rebecca L. Sammak, Rachel Pollard, J. Rachel Reader, Katherine J. Olstad, Lark L. Coffey, Pamela A. Kozlowski, Dennis J. Hartigan-O’Connor, Michel Nussenzweig, Koen K.A. Van Rompay, John H. Morrison, Smita S. Iyer
Published 2021-11-01

SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma

by Jesse D. Deere, Timothy D. Carroll, Joseph Dutra, Linda Fritts, Rebecca Lee Sammak, JoAnn L. Yee, Katherine J. Olstad, J. Rachel Reader, Amy Kistler, Jack Kamm, Clara Di Germanio, Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh, Graham Simmons, Jennifer Watanabe, Rachel E. Pollard, Jodie Usachenko, Ramya Immareddy, Brian A. Schmidt, Shelby L. O’Connor, Joseph DeRisi, Michael P. Busch, Smita S. Iyer, Koen K. A. Van Rompay, Dennis J. Hartigan-O’Connor, Christopher J. Miller
Published 2021-12-01

Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaq...

by Koen K A Van Rompay, Katherine J Olstad, Rebecca L Sammak, Joseph Dutra, Jennifer K Watanabe, Jodie L Usachenko, Ramya Immareddy, Anil Verma, Yashavanth Shaan Lakshmanappa, Brian A Schmidt, Jamin W Roh, Sonny R Elizaldi, A Mark Allen, Frauke Muecksch, Julio C C Lorenzi, Sarah Lockwood, Rachel E Pollard, JoAnn L Yee, Peter B Nham, Amir Ardeshir, Jesse D Deere, Jean Patterson, Que Dang, Theodora Hatziioannou, Paul D Bieniasz, Smita S Iyer, Dennis J Hartigan-O'Connor, Michel C Nussenzweig, J Rachel Reader
Published 2021-07-01

SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

by Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh, Brian A. Schmidt, Timothy D. Carroll, Kourtney D. Weaver, Justin C. Smith, Anil Verma, Jesse D. Deere, Joseph Dutra, Mars Stone, Sergej Franz, Rebecca Lee Sammak, Katherine J. Olstad, J. Rachel Reader, Zhong-Min Ma, Nancy K. Nguyen, Jennifer Watanabe, Jodie Usachenko, Ramya Immareddy, JoAnn L. Yee, Daniela Weiskopf, Alessandro Sette, Dennis Hartigan-O’Connor, Stephen J. McSorley, John H. Morrison, Nam K. Tran, Graham Simmons, Michael P. Busch, Pamela A. Kozlowski, Koen K. A. Van Rompay, Christopher J. Miller, Smita S. Iyer
Published 2021-01-01

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung i...

by Koen K A Van Rompay, Katherine J Olstad, Rebecca L Sammak, Joseph Dutra, Jennifer K Watanabe, Jodie L Usachenko, Ramya Immareddy, Jamin W Roh, Anil Verma, Yashavanth Shaan Lakshmanappa, Brian A Schmidt, Clara Di Germanio, Nabeela Rizvi, Hongwei Liu, Zhong-Min Ma, Mars Stone, Graham Simmons, Larry J Dumont, A Mark Allen, Sarah Lockwood, Rachel E Pollard, Rafael Ramiro de Assis, JoAnn L Yee, Peter B Nham, Amir Ardeshir, Jesse D Deere, Aarti Jain, Philip L Felgner, Lark L Coffey, Smita S Iyer, Dennis J Hartigan-O'Connor, Michael P Busch, J Rachel Reader
Published 2022-04-01