Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaq...

by Koen K A Van Rompay, Katherine J Olstad, Rebecca L Sammak, Joseph Dutra, Jennifer K Watanabe, Jodie L Usachenko, Ramya Immareddy, Anil Verma, Yashavanth Shaan Lakshmanappa, Brian A Schmidt, Jamin W Roh, Sonny R Elizaldi, A Mark Allen, Frauke Muecksch, Julio C C Lorenzi, Sarah Lockwood, Rachel E Pollard, JoAnn L Yee, Peter B Nham, Amir Ardeshir, Jesse D Deere, Jean Patterson, Que Dang, Theodora Hatziioannou, Paul D Bieniasz, Smita S Iyer, Dennis J Hartigan-O'Connor, Michel C Nussenzweig, J Rachel Reader
Published 2021-07-01

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung i...

by Koen K A Van Rompay, Katherine J Olstad, Rebecca L Sammak, Joseph Dutra, Jennifer K Watanabe, Jodie L Usachenko, Ramya Immareddy, Jamin W Roh, Anil Verma, Yashavanth Shaan Lakshmanappa, Brian A Schmidt, Clara Di Germanio, Nabeela Rizvi, Hongwei Liu, Zhong-Min Ma, Mars Stone, Graham Simmons, Larry J Dumont, A Mark Allen, Sarah Lockwood, Rachel E Pollard, Rafael Ramiro de Assis, JoAnn L Yee, Peter B Nham, Amir Ardeshir, Jesse D Deere, Aarti Jain, Philip L Felgner, Lark L Coffey, Smita S Iyer, Dennis J Hartigan-O'Connor, Michael P Busch, J Rachel Reader
Published 2022-04-01