Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation

by Anil Verma, Chase E. Hawes, Yashavanth Shaan Lakshmanappa, Jamin W. Roh, Brian A. Schmidt, Joseph Dutra, William Louie, Hongwei Liu, Zhong-Min Ma, Jennifer K. Watanabe, Jodie L. Usachenko, Ramya Immareddy, Rebecca L. Sammak, Rachel Pollard, J. Rachel Reader, Katherine J. Olstad, Lark L. Coffey, Pamela A. Kozlowski, Dennis J. Hartigan-O’Connor, Michel Nussenzweig, Koen K.A. Van Rompay, John H. Morrison, Smita S. Iyer
Published 2021-11-01

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

by Luigi Fontana, Nicole E. Cummings, Sebastian I. Arriola Apelo, Joshua C. Neuman, Ildiko Kasza, Brian A. Schmidt, Edda Cava, Francesco Spelta, Valeria Tosti, Faizan A. Syed, Emma L. Baar, Nicola Veronese, Sara E. Cottrell, Rachel J. Fenske, Beatrice Bertozzi, Harpreet K. Brar, Terri Pietka, Arnold D. Bullock, Robert S. Figenshau, Gerald L. Andriole, Matthew J. Merrins, Caroline M. Alexander, Michelle E. Kimple, Dudley W. Lamming
Published 2016-07-01

SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma

by Jesse D. Deere, Timothy D. Carroll, Joseph Dutra, Linda Fritts, Rebecca Lee Sammak, JoAnn L. Yee, Katherine J. Olstad, J. Rachel Reader, Amy Kistler, Jack Kamm, Clara Di Germanio, Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh, Graham Simmons, Jennifer Watanabe, Rachel E. Pollard, Jodie Usachenko, Ramya Immareddy, Brian A. Schmidt, Shelby L. O’Connor, Joseph DeRisi, Michael P. Busch, Smita S. Iyer, Koen K. A. Van Rompay, Dennis J. Hartigan-O’Connor, Christopher J. Miller
Published 2021-12-01

Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaq...

by Koen K A Van Rompay, Katherine J Olstad, Rebecca L Sammak, Joseph Dutra, Jennifer K Watanabe, Jodie L Usachenko, Ramya Immareddy, Anil Verma, Yashavanth Shaan Lakshmanappa, Brian A Schmidt, Jamin W Roh, Sonny R Elizaldi, A Mark Allen, Frauke Muecksch, Julio C C Lorenzi, Sarah Lockwood, Rachel E Pollard, JoAnn L Yee, Peter B Nham, Amir Ardeshir, Jesse D Deere, Jean Patterson, Que Dang, Theodora Hatziioannou, Paul D Bieniasz, Smita S Iyer, Dennis J Hartigan-O'Connor, Michel C Nussenzweig, J Rachel Reader
Published 2021-07-01

SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

by Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh, Brian A. Schmidt, Timothy D. Carroll, Kourtney D. Weaver, Justin C. Smith, Anil Verma, Jesse D. Deere, Joseph Dutra, Mars Stone, Sergej Franz, Rebecca Lee Sammak, Katherine J. Olstad, J. Rachel Reader, Zhong-Min Ma, Nancy K. Nguyen, Jennifer Watanabe, Jodie Usachenko, Ramya Immareddy, JoAnn L. Yee, Daniela Weiskopf, Alessandro Sette, Dennis Hartigan-O’Connor, Stephen J. McSorley, John H. Morrison, Nam K. Tran, Graham Simmons, Michael P. Busch, Pamela A. Kozlowski, Koen K. A. Van Rompay, Christopher J. Miller, Smita S. Iyer
Published 2021-01-01

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung i...

by Koen K A Van Rompay, Katherine J Olstad, Rebecca L Sammak, Joseph Dutra, Jennifer K Watanabe, Jodie L Usachenko, Ramya Immareddy, Jamin W Roh, Anil Verma, Yashavanth Shaan Lakshmanappa, Brian A Schmidt, Clara Di Germanio, Nabeela Rizvi, Hongwei Liu, Zhong-Min Ma, Mars Stone, Graham Simmons, Larry J Dumont, A Mark Allen, Sarah Lockwood, Rachel E Pollard, Rafael Ramiro de Assis, JoAnn L Yee, Peter B Nham, Amir Ardeshir, Jesse D Deere, Aarti Jain, Philip L Felgner, Lark L Coffey, Smita S Iyer, Dennis J Hartigan-O'Connor, Michael P Busch, J Rachel Reader
Published 2022-04-01