High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

by Jeffrey L. Bessen, Lena K. Afeyan, Vlado Dančík, Luke W. Koblan, David B. Thompson, Chas Leichner, Paul A. Clemons, David R. Liu
Published 2019-04-01

Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

by Jeffrey L. Bessen, Lena K. Afeyan, Vlado Dančík, Luke W. Koblan, David B. Thompson, Chas Leichner, Paul A. Clemons, David R. Liu
Published 2019-07-01

Knowledge Beacons: Web services for data harvesting of distributed biomedical knowledge.

by Lance M Hannestad, Vlado Dančík, Meera Godden, Imelda W Suen, Kenneth C Huellas-Bruskiewicz, Benjamin M Good, Christopher J Mungall, Richard M Bruskiewich
Published 2021-01-01

Predicting compound activity from phenotypic profiles and chemical structures

by Nikita Moshkov, Tim Becker, Kevin Yang, Peter Horvath, Vlado Dancik, Bridget K. Wagner, Paul A. Clemons, Shantanu Singh, Anne E. Carpenter, Juan C. Caicedo
Published 2023-04-01

Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming.

by Amit Choudhary, Kaihui Hu He, Philipp Mertins, Namrata D Udeshi, Vlado Dančík, Dina Fomina-Yadlin, Stefan Kubicek, Paul A Clemons, Stuart L Schreiber, Steven A Carr, Bridget K Wagner
Published 2014-01-01

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

by Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Kost-Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John G. Doench, Clary B. Clish, Paul A. Clemons, Stuart L. Schreiber
Published 2019-04-01

Progress toward a universal biomedical data translator

by Karamarie Fecho, Anne E. Thessen, Sergio E. Baranzini, Chris Bizon, Jennifer J. Hadlock, Sui Huang, Ryan T. Roper, Noel Southall, Casey Ta, Paul B. Watkins, Mark D. Williams, Hao Xu, William Byrd, Vlado Dančík, Marc P. Duby, Michel Dumontier, Gustavo Glusman, Nomi L. Harris, Eugene W. Hinderer, Greg Hyde, Adam Johs, Andrew I. Su, Guangrong Qin, Qian Zhu, The Biomedical Data Translator Consortium
Published 2022-08-01

Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science

by Deepak R. Unni, Sierra A. T. Moxon, Michael Bada, Matthew Brush, Richard Bruskiewich, J. Harry Caufield, Paul A. Clemons, Vlado Dancik, Michel Dumontier, Karamarie Fecho, Gustavo Glusman, Jennifer J. Hadlock, Nomi L. Harris, Arpita Joshi, Tim Putman, Guangrong Qin, Stephen A. Ramsey, Kent A. Shefchek, Harold Solbrig, Karthik Soman, Anne E. Thessen, Melissa A. Haendel, Chris Bizon, Christopher J. Mungall, The Biomedical Data Translator Consortium
Published 2022-08-01

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.

by Gang Li, Dorothée Diogo, Di Wu, Jim Spoonamore, Vlado Dancik, Lude Franke, Fina Kurreeman, Elizabeth J Rossin, Grant Duclos, Cathy Hartland, Xuezhong Zhou, Kejie Li, Jun Liu, Philip L De Jager, Katherine A Siminovitch, Alexandra Zhernakova, Soumya Raychaudhuri, John Bowes, Steve Eyre, Leonid Padyukov, Peter K Gregersen, Jane Worthington, Rheumatoid Arthritis Consortium International (RACI), Namrata Gupta, Paul A Clemons, Eli Stahl, Nicola Tolliday, Robert M Plenge
Published 2013-05-01

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors

by Shrikanta Chattopadhyay, Alison L. Stewart, Siddhartha Mukherjee, Cherrie Huang, Kimberly A. Hartwell, Peter G. Miller, Radhika Subramanian, Leigh C. Carmody, Rushdia Z. Yusuf, David B. Sykes, Joshiawa Paulk, Amedeo Vetere, Sonia Vallet, Loredana Santo, Diana D. Cirstea, Teru Hideshima, Vlado Dančík, Max M. Majireck, Mahmud M. Hussain, Shambhavi Singh, Ryan Quiroz, Jonathan Iaconelli, Rakesh Karmacharya, Nicola J. Tolliday, Paul A. Clemons, Malcolm A.S. Moore, Andrew M. Stern, Alykhan F. Shamji, Benjamin L. Ebert, Todd R. Golub, Noopur S. Raje, David T. Scadden, Stuart L. Schreiber
Published 2015-02-01

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

by Kuo, Szu-Yu, Castoreno, Adam, Aldrich, Leslie, Lassen, Kara, Goel, Gautam, Dančík, Vlado, Kuballa, Petric, Latorre, Isabel, Conway, Kara, Sarkar, Sovan, Maetzel, Dorothea, Jaenisch, Rudolf, Clemons, Paul, Schreiber, Stuart, Shamji, Alykhan, Xavier, Ramnik
Published 2019

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

by Kuo, Szu-Yu, Castoreno, Adam B., Aldrich, Leslie N., Lassen, Kara G., Goel, Gautam, Dancik, Vlado, Kuballa, Petric, Latorre, Isabel, Conway, Kara L., Sarkar, Sovan, Maetzel, Dorothea, Jaenisch, Rudolf, Clemons, Paul A., Schreiber, Stuart L., Shamji, Alykhan F., Xavier, Ramnik J.
Published 2016

Quantitative-Proteomic Comparison of Alpha and Beta Cells to Uncover Novel Targets for Lineage Reprogramming

by Choudhary, Amit, Hu He, Kaihui, Mertins, Philipp, Udeshi, Namrata D., Dancik, Vlado, Fomina-Yadlin, Dina, Kubicek, Stefan, Clemons, Paul A., Schreiber, Stuart L., Wagner, Bridget K., Carr, Steven A
Published 2014

An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules

by Basu, Amrita, Bodycombe, Nicole E., Cheah, Jaime H., Price, Edmund V., Liu, Ke, Schaefer, Giannina Ines, Ebright, Richard Yon, Stewart, Michelle L., Ito, Daisuke, Wang, Stephanie, Bracha, Abigail L., Liefeld, Ted, Wawer, Mathias, Gilbert, Joshua C., Wilson, Andrew J., Stransky, Nicolas, Kryukov, Gregory V., Dancik, Vlado, Barretina, Jordi, Garraway, Levi Alexander, Hon, C. Suk-Yee, Munoz, Benito, Bittker, Joshua A., Stockwell, Brent R., Khabele, Dineo, Stern, Andrew M., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.
Published 2018

Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

by Li, Gang, Diogo, Dorothee, Wu, Di, Spoonamore, Jim, Dancik, Vlado, Franke, Lude, Kurreeman, Fina, Rossin, Elizabeth Jeffries, Duclos, Grant, Hartland, Cathy, Zhou, Xuezhong, Li, Kejie, Liu, Jun, De Jager, Philip Lawrence, Siminovitch, Katherine A., Zhernakova, Alexandra, Raychaudhuri, Soumya, Bowes, John, Eyre, Steve, Padyukov, Leonid, Gregersen, Peter K., Worthington, Jane, Gupta, Namrata, Clemons, Paul A., Stahl, Eli, Tolliday, Nicola, Plenge, Robert M.
Published 2014