NUP98 and KMT2A: usually the bride rather than the bridesmaid

by Alexandre Fagnan, Thomas Mercher
Published 2020-07-01

From hypoxia single‐cell gene signatures to HIF targeting of AML leukemic stem cells

by Thomas Mercher, Juerg Schwaller
Published 2024-03-01

Corrigendum: Pediatric Acute Myeloid Leukemia (AML): From Genes to Models Toward Targeted Therapeutic Intervention

by Thomas Mercher, Juerg Schwaller
Published 2019-11-01

Pediatric Acute Myeloid Leukemia (AML): From Genes to Models Toward Targeted Therapeutic Intervention

by Thomas Mercher, Juerg Schwaller
Published 2019-10-01

Molecular pathways driven by ETO2-GLIS2 in aggressive pediatric leukemia

by Cécile Thirant, Cécile Lopez, Sébastien Malinge, Thomas Mercher
Published 2017-11-01

Molecular Landscapes and Models of Acute Erythroleukemia

by Alexandre Fagnan, Maria-Riera Piqué-Borràs, Samantha Tauchmann, Thomas Mercher, Juerg Schwaller
Published 2021-05-01

JAM-C/Jam-C Expression Is Primarily Expressed in Mouse Hematopoietic Stem Cells

by Elia Henry, Vilma Barroca, Cécile K. Lopez, Michel Aurrand-Lions, Daniel Lewandowski, Thomas Mercher, Marie-Laure Arcangeli
Published 2021-07-01

Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells

by Loelia Babin, Marion Piganeau, Benjamin Renouf, Khadija Lamribet, Cecile Thirant, Ludovic Deriano, Thomas Mercher, Carine Giovannangeli, Erika C. Brunet
Published 2018-07-01

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia

by Katharina Leonards, Marwa Almosailleakh, Samantha Tauchmann, Frederik Otzen Bagger, Cécile Thirant, Sabine Juge, Thomas Bock, Hélène Méreau, Matheus F. Bezerra, Alexandar Tzankov, Robert Ivanek, Régine Losson, Antoine H. F. M. Peters, Thomas Mercher, Juerg Schwaller
Published 2020-06-01

Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis

by Sumin Koo, Brian J. Huntly, Yuan Wang, Jing Chen, Kristina Brumme, Brian Ball, Shannon L. McKinney-Freeman, Akiko Yabuuchi, Claudia Scholl, Dimple Bansal, Leonard I. Zon, Stefan Fröhling, George Q. Daley, D. Gary Gilliland, Thomas Mercher
Published 2010-10-01

The Pediatric Acute Leukemia Fusion Oncogene ETO2-GLIS2 Increases Self-Renewal and Alters Differentiation in a Human Induced Pluripotent Stem Cells-Derived Model

by Salvatore Nicola Bertuccio, Fabien Boudia, Marie Cambot, Cécile K. Lopez, Larissa Lordier, Alessandro Donada, Elie Robert, Cécile Thirant, Zakia Aid, Salvatore Serravalle, Annalisa Astolfi, Valentina Indio, Franco Locatelli, Andrea Pession, William Vainchenker, Riccardo Masetti, Hana Raslova, Thomas Mercher
Published 2020-02-01

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

by Yana Pikman, Benjamin H Lee, Thomas Mercher, Elizabeth McDowell, Benjamin L Ebert, Maricel Gozo, Adam Cuker, Gerlinde Wernig, Sandra Moore, Ilene Galinsky, Daniel J DeAngelo, Jennifer J Clark, Stephanie J Lee, Todd R Golub, Martha Wadleigh, D Gary Gilliland, Ross L Levine
Published 2006-07-01

De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells

by Loélia Babin, Alice Darchen, Elie Robert, Zakia Aid, Rosalie Borry, Claire Soudais, Marion Piganeau, Anne De Cian, Carine Giovannangeli, Olivia Bawa, Charlotte Rigaud, Jean-Yves Scoazec, Lucile Couronné, Layla Veleanu, Agata Cieslak, Vahid Asnafi, David Sibon, Laurence Lamant, Fabienne Meggetto, Thomas Mercher, Erika Brunet
Published 2022-03-01

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model

by Lucile Couronné, Laurianne Scourzic, Camilla Pilati, Véronique Della Valle, Yannis Duffourd, Eric Solary, William Vainchenker, Jean-Philippe Merlio, Marie Beylot-Barry, Frederik Damm, Marc-Henri Stern, Philippe Gaulard, Laurence Lamant, Eric Delabesse, Hélène Merle-Beral, Florence Nguyen-Khac, Michaëla Fontenay, Hervé Tilly, Christian Bastard, Jessica Zucman-Rossi, Olivier A. Bernard, Thomas Mercher
Published 2013-11-01

The ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300‐dependent stemness program

by Alexandre Fagnan, Zakia Aid, Marie Baille, Aneta Drakul, Elie Robert, Cécile K. Lopez, Cécile Thirant, Yann Lecluse, Julie Rivière, Cathy Ignacimouttou, Silvia Salmoiraghi, Eduardo Anguita, Audrey Naimo, Christophe Marzac, Françoise Pflumio, Sébastien Malinge, Christian Wichmann, Yun Huang, Camille Lobry, Julie Chaumeil, Eric Soler, Jean‐Pierre Bourquin, Claus Nerlov, Olivier A. Bernard, Juerg Schwaller, Thomas Mercher
Published 2024-06-01

Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia

by Shannon L. Carey-Smith, Maryam H. Simad, Kunjal Panchal, Carlos Aya-Bonilla, Hannah Smolders, Sang Lin, Jesse D. Armitage, Vivien T. Nguyen, Kathryn Bentley, Jette Ford, Sajla Singh, Joyce Oommen, Anouchka P. Laurent, Thomas Mercher, John D. Crispino, Andrew P. Montgomery, Michael Kassiou, Thierry Besson, Emmanuel Deau, Laurent Meijer, Laurence C. Cheung, Rishi S. Kotecha, Sébastien Malinge
Published 2024-02-01

Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model

by Brahim Arkoun, Elie Robert, Fabien Boudia, Stefania Mazzi, Virginie Dufour, Aurélie Siret, Yasmine Mammasse, Zakia Aid, Matthieu Vieira, Aygun Imanci, Marine Aglave, Marie Cambot, Rachel Petermann, Sylvie Souquere, Philippe Rameau, Cyril Catelain, Romain Diot, Gérard Tachdjian, Olivier Hermine, Nathalie Droin, Najet Debili, Isabelle Plo, Sébastien Malinge, Eric Soler, Hana Raslova, Thomas Mercher, William Vainchenker
Published 2023-04-01

A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors

by Maria Eugénia Marques Da Costa, Sakina Zaidi, Jean-Yves Scoazec, Robin Droit, Wan Ching Lim, Antonin Marchais, Jerome Salmon, Sarah Cherkaoui, Raphael J. Morscher, Anouchka Laurent, Sébastien Malinge, Thomas Mercher, Séverine Tabone-Eglinger, Isabelle Goddard, Francoise Pflumio, Julien Calvo, Francoise Redini, Natacha Entz-Werlé, Aroa Soriano, Alberto Villanueva, Stefano Cairo, Pascal Chastagner, Massimo Moro, Cormac Owens, Michela Casanova, Raquel Hladun-Alvaro, Pablo Berlanga, Estelle Daudigeos-Dubus, Philippe Dessen, Laurence Zitvogel, Ludovic Lacroix, Gaelle Pierron, Olivier Delattre, Gudrun Schleiermacher, Didier Surdez, Birgit Geoerger
Published 2023-09-01