Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview

by Mattias F. Lindberg, Laurent Meijer
Published 2021-06-01

The protein kinase CK1: Inhibition, activation, and possible allosteric modulation

by Yashoda Krishna Sunkari, Laurent Meijer, Marc Flajolet
Published 2022-08-01

An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs

by Svenja Koslowski, Camille Latapy, Pierrïck Auvray, Marc Blondel, Laurent Meijer
Published 2020-06-01

Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

by Damien Hédou, Julien Godeau, Nadège Loaëc, Laurent Meijer, Corinne Fruit, Thierry Besson
Published 2016-04-01

Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models.

by Bénédicte Menn, Stéphane Bach, Teri L Blevins, Mark Campbell, Laurent Meijer, Serge Timsit
Published 2010-08-01

Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation

by Damien Hédou, Carole Dubouilh-Benard, Nadège Loaëc, Laurent Meijer, Corinne Fruit, Thierry Besson
Published 2016-06-01

Non-Linear Pharmacokinetics of Oral Roscovitine (Seliciclib) in Cystic Fibrosis Patients Chronically Infected with <i>Pseudomonas aeruginosa</i>: A Study on Population Pharmacokine...

by Cyril Leven, Sacha Schutz, Marie-Pierre Audrezet, Emmanuel Nowak, Laurent Meijer, Tristan Montier
Published 2020-11-01

A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

by Jean Pierre Bazureau, Laurent Meijer, Olivier Lozach, Ludovic Paquin, Khadidja Bourahla, François Carreaux
Published 2011-08-01

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design

by Rosanna Meine, Walter Becker, Hannes Falke, Lutz Preu, Nadège Loaëc, Laurent Meijer, Conrad Kunick
Published 2018-01-01

A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back...

by Krystel El Hage, Jean-Philip Piquemal, Nassima Oumata, Laurent Meijer, Hervé Galons, Nohad Gresh
Published 2017-07-01

(R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages

by Chandra L. Shrestha, Shuzhong Zhang, Benjamin Wisniewski, Stephanie Häfner, Jonathan Elie, Laurent Meijer, Benjamin T. Kopp
Published 2020-12-01

Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance

by Vassilios Myrianthopoulos, Olivier Lozach, Danae Zareifi, Leonidas Alexopoulos, Laurent Meijer, Vassilis G. Gorgoulis, Emmanuel Mikros
Published 2017-10-01

Exploring Kinase Inhibition Properties of 9<i>H</i>-pyrimido[5,4-<i>b</i>]- and [4,5-<i>b</i>]indol-4-amine Derivatives

by Yvonnick Loidreau, Carole Dubouilh-Benard, Marie-Renée Nourrisson, Nadège Loaëc, Laurent Meijer, Thierry Besson, Pascal Marchand
Published 2020-05-01

Several Human Cyclin-Dependent Kinase Inhibitors, Structurally Related to Roscovitine, As New Anti-Malarial Agents

by Sandrine Houzé, Nha-Thu Hoang, Olivier Lozach, Jacques Le Bras, Laurent Meijer, Hervé Galons, Luc Demange
Published 2014-09-01

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.

by Anne Walter, Apirat Chaikuad, Renate Helmer, Nadège Loaëc, Lutz Preu, Ingo Ott, Stefan Knapp, Laurent Meijer, Conrad Kunick
Published 2018-01-01

Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I

by Alicia Foucourt, Damien Hédou, Carole Dubouilh-Benard, Laurent Désiré, Anne-Sophie Casagrande, Bertrand Leblond, Nadège Loäec, Laurent Meijer, Thierry Besson
Published 2014-09-01

Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.

by Fei He, Linh H. Mai, Arlette Longeon, Brent R. Copp, Nadège Loaëc, Amandine Bescond, Laurent Meijer, Marie-Lise Bourguet-Kondracki
Published 2015-04-01

Development of Kinase Inhibitors via Metal-Catalyzed C–H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies

by Florence Couly, Marine Harari, Carole Dubouilh-Benard, Laetitia Bailly, Emilie Petit, Julien Diharce, Pascal Bonnet, Laurent Meijer, Corinne Fruit, Thierry Besson
Published 2018-08-01

Anticancer Alkaloid Lamellarins Inhibit Protein Kinases

by Laurent Meijer, Masatomo Iwao, Fumito Ishibashi, Somsak Rucirawat, Poonsakdi Ploypradith, Olivier Lozach, Yoan Ferandin, Nolwenn Trinkler, Dianne Baunbæk
Published 2008-10-01

A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge <i>Acanthostrongylophora ingens</i>

by Germana Esposito, Linh H. Mai, Arlette Longeon, Alfonso Mangoni, Emilie Durieu, Laurent Meijer, Rob Van Soest, Valeria Costantino, Marie-Lise Bourguet-Kondracki
Published 2019-08-01