Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection

by Mazharul Maishan, Aartik Sarma, Aartik Sarma, Lauren F. Chun, Saharai Caldera, Xiaohui Fang, Jason Abbott, Stephanie A. Christenson, Stephanie A. Christenson, Charles R. Langelier, Charles R. Langelier, Carolyn S. Calfee, Carolyn S. Calfee, Carolyn S. Calfee, Carolyn S. Calfee, Jeffrey E. Gotts, Jeffrey E. Gotts, Jeffrey E. Gotts, Michael A. Matthay, Michael A. Matthay, Michael A. Matthay
Published 2023-03-01

Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity

by Alane Blythe C. Dy, Paul R. Langlais, Natalie K. Barker, Kenneth J. Addison, Sasipa Tanyaratsrisakul, Scott Boitano, Stephanie A. Christenson, Monica Kraft, Deborah Meyers, Eugene R. Bleecker, Xingnan Li, Julie G. Ledford
Published 2021-12-01

High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis

by Arindam Chakrabarti, Jordan S. Mar, David F. Choy, Yi Cao, Nisha Rathore, Xiaoying Yang, Gaik W. Tew, Olga Li, Prescott G. Woodruff, Christopher E. Brightling, Michele Grimbaldeston, Stephanie A. Christenson, Mona Bafadhel, Carrie M. Rosenberger
Published 2021-08-01

The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils

by Benedikt Ditz, Aartik Sarma, Huib A.M. Kerstjens, Jeroen J.W. Liesker, Erik Bathoorn, Judith M. Vonk, Victor Bernal, Peter Horvatovich, Victor Guryev, Saharai Caldera, Chaz Langelier, Alen Faiz, Stephanie A. Christenson, Maarten van den Berge
Published 2021-07-01

15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation

by Tadao Nagasaki, Alexander J. Schuyler, Jinming Zhao, Svetlana N. Samovich, Kazuhiro Yamada, Yanhan Deng, Scott P. Ginebaugh, Stephanie A. Christenson, Prescott G. Woodruff, John V. Fahy, John B. Trudeau, Detcho Stoyanovsky, Anuradha Ray, Yulia Y. Tyurina, Valerian E. Kagan, Sally E. Wenzel
Published 2022-01-01

Genome-wide association study of lung function and clinical implication in heavy smokers

by Xingnan Li, Victor E. Ortega, Elizabeth J. Ampleford, R. Graham Barr, Stephanie A. Christenson, Christopher B. Cooper, David Couper, Mark T. Dransfield, Mei Lan K. Han, Nadia N. Hansel, Eric A. Hoffman, Richard E. Kanner, Eric C. Kleerup, Fernando J. Martinez, Robert Paine, Prescott G. Woodruff, Gregory A. Hawkins, Eugene R. Bleecker, Deborah A. Meyers, for the SPIROMICS Research Group
Published 2018-08-01

Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses

by Eran Mick, Jack Kamm, Angela Oliveira Pisco, Kalani Ratnasiri, Jennifer M. Babik, Gloria Castañeda, Joseph L. DeRisi, Angela M. Detweiler, Samantha L. Hao, Kirsten N. Kangelaris, G. Renuka Kumar, Lucy M. Li, Sabrina A. Mann, Norma Neff, Priya A. Prasad, Paula Hayakawa Serpa, Sachin J. Shah, Natasha Spottiswoode, Michelle Tan, Carolyn S. Calfee, Stephanie A. Christenson, Amy Kistler, Charles Langelier
Published 2020-11-01

Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes.

by Eric Van Buren, Giorgia Radicioni, Sarah Lester, Wanda K O'Neal, Hong Dang, Silva Kasela, Suresh Garudadri, Jeffrey L Curtis, MeiLan K Han, Jerry A Krishnan, Emily S Wan, Edwin K Silverman, Annette Hastie, Victor E Ortega, Tuuli Lappalainen, Martijn C Nawijn, Maarten van den Berge, Stephanie A Christenson, Yun Li, Michael H Cho, Mehmet Kesimer, Samir N P Kelada
Published 2023-06-01

Heterogeneous burden of lung disease in smokers with borderline airflow obstruction

by Cheryl S. Pirozzi, Tian Gu, Pedro M. Quibrera, Elizabeth E. Carretta, MeiLan K. Han, Susan Murray, Christopher B. Cooper, Donald P. Tashkin, Eric C. Kleerup, Igor Barjaktarevic, Eric A. Hoffman, Carlos H. Martinez, Stephanie A. Christenson, Nadia N. Hansel, R. Graham Barr, Eugene R. Bleecker, Victor E. Ortega, Fernando J. Martinez, Richard E. Kanner, Robert Paine, for the NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS)
Published 2018-11-01

NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes

by Daniel R. Calabrese, Tasha Tsao, Mélia Magnen, Colin Valet, Ying Gao, Beñat Mallavia, Jennifer J. Tian, Emily A. Aminian, Kristin M. Wang, Avishai Shemesh, Elman B. Punzalan, Aartik Sarma, Carolyn S. Calfee, Stephanie A. Christenson, Charles R. Langelier, Steven R. Hays, Jeffrey A. Golden, Lorriana E. Leard, Mary Ellen Kleinhenz, Nicholas A. Kolaitis, Rupal Shah, Aida Venado, Lewis L. Lanier, John R. Greenland, David M. Sayah, Abbas Ardehali, Jasleen Kukreja, S. Samuel Weigt, John A. Belperio, Jonathan P. Singer, Mark R. Looney
Published 2022-12-01

Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease

by Preeti Lakshman Kumar, Ava C. Wilson, Alison Rocco, Michael H. Cho, Emily Wan, Brian D. Hobbs, George R. Washko, Victor E. Ortega, Stephanie A. Christenson, Xingnan Li, J. Michael Wells, Surya P. Bhatt, Dawn L. DeMeo, Sharon M. Lutz, Harry Rossiter, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Wassim W. Labaki, Ruth Tal‐Singer, Russel P. Bowler, Craig P. Hersh, Hemant K. Tiwari, Mark Dransfield, Anna Thalacker‐Mercer, Deborah A. Meyers, Edwin K. Silverman, Merry‐Lynn N. McDonald, COPDGene, ECLIPSE and SPIROMICS investigators
Published 2021-12-01

Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS

by Aartik Sarma, Stephanie A. Christenson, Ashley Byrne, Eran Mick, Angela Oliveira Pisco, Catherine DeVoe, Thomas Deiss, Rajani Ghale, Beth Shoshana Zha, Alexandra Tsitsiklis, Alejandra Jauregui, Farzad Moazed, Angela M. Detweiler, Natasha Spottiswoode, Pratik Sinha, Norma Neff, Michelle Tan, Paula Hayakawa Serpa, Andrew Willmore, K. Mark Ansel, Jennifer G. Wilson, Aleksandra Leligdowicz, Emily R. Siegel, Marina Sirota, Joseph L. DeRisi, Michael A. Matthay, COMET Consortium, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Matthew F. Krummel, Prescott G. Woodruff, David J. Erle, Carolyn S. Calfee, Charles R. Langelier
Published 2021-08-01

Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort

by Kristopher Opron, Lesa A. Begley, John R. Erb-Downward, Christine Freeman, Siddharth Madapoosi, Neil E. Alexis, Igor Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Stephanie A. Christenson, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Claire M. Doerschuk, Mark T. Dransfield, MeiLan K. Han, Nadia N. Hansel, Annette T. Hastie, Eric A. Hoffman, Robert J. Kaner, Jerry Krishnan, Wanda K. O’Neal, Victor E. Ortega, Robert Paine, Stephen P. Peters, J. Michael Wells, Prescott G. Woodruff, Fernando J. Martinez, Jeffrey L. Curtis, Gary B. Huffnagle, Yvonne J. Huang
Published 2021-02-01

A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD

by Katarina M. DiLillo, Katy C. Norman, Christine M. Freeman, Stephanie A. Christenson, Neil E. Alexis, Wayne H. Anderson, Igor Z. Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, Eugene R. Bleecker, Richard C. Boucher, David J. Couper, Gerard J. Criner, Claire M. Doerschuk, J. Michael Wells, MeiLan K. Han, Eric A. Hoffman, Nadia N. Hansel, Annette T. Hastie, Robert J. Kaner, Jerry A. Krishnan, Wassim W. Labaki, Fernando J. Martinez, Deborah A. Meyers, Wanda K. O’Neal, Victor E. Ortega, Robert Paine, Stephen P. Peters, Prescott G. Woodruff, Christopher B. Cooper, Russell P. Bowler, Jeffrey L. Curtis, Kelly B. Arnold, SPIROMICS investigators
Published 2023-05-01

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

by Wei Sun, Katerina Kechris, Sean Jacobson, M Bradley Drummond, Gregory A Hawkins, Jenny Yang, Ting-Huei Chen, Pedro Miguel Quibrera, Wayne Anderson, R Graham Barr, Patricia V Basta, Eugene R Bleecker, Terri Beaty, Richard Casaburi, Peter Castaldi, Michael H Cho, Alejandro Comellas, James D Crapo, Gerard Criner, Dawn Demeo, Stephanie A Christenson, David J Couper, Jeffrey L Curtis, Claire M Doerschuk, Christine M Freeman, Natalia A Gouskova, MeiLan K Han, Nicola A Hanania, Nadia N Hansel, Craig P Hersh, Eric A Hoffman, Robert J Kaner, Richard E Kanner, Eric C Kleerup, Sharon Lutz, Fernando J Martinez, Deborah A Meyers, Stephen P Peters, Elizabeth A Regan, Stephen I Rennard, Mary Beth Scholand, Edwin K Silverman, Prescott G Woodruff, Wanda K O'Neal, Russell P Bowler, SPIROMICS Research Group, COPDGene Investigators
Published 2016-08-01

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

by Silva Kasela, Victor E. Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, Srilaxmi Nerella, Kristina L. Buschur, Igor Z. Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Gerard J. Criner, Jeffrey L. Curtis, MeiLan K. Han, Nadia N. Hansel, Eric A. Hoffman, Robert J. Kaner, Jerry A. Krishnan, Fernando J. Martinez, Merry-Lynn N. McDonald, Deborah A. Meyers, Robert Paine, Stephen P. Peters, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Xingnan Li, Wendy C. Moore, Sally E. Wenzel, Joe Zein, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Charles Langelier, Prescott G. Woodruff, Tuuli Lappalainen, Stephanie A. Christenson
Published 2021-04-01