Mitochondrial fission in Huntington's disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca2+ efflux and Reactive Oxygen Species (ROS) homeostasis

by Marta Cherubini, Laura Lopez-Molina, Silvia Gines
Published 2020-03-01

A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice

by Nuria Suelves, Lucy Kirkham-McCarthy, Robert S. Lahue, Silvia Ginés
Published 2017-07-01

CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease.

by Andrea Comella Bolla, Tony Valente, Andres Miguez, Veronica Brito, Silvia Gines, Carme Solà, Marco Straccia, Josep M Canals
Published 2019-01-01

Lack of Helios During Neural Development Induces Adult Schizophrenia-Like Behaviors Associated With Aberrant Levels of the TRIF-Recruiter Protein WDFY1

by Anna Sancho-Balsells, Anna Sancho-Balsells, Anna Sancho-Balsells, Anna Sancho-Balsells, Veronica Brito, Veronica Brito, Veronica Brito, Veronica Brito, Belissa Fernández, Belissa Fernández, Belissa Fernández, Belissa Fernández, Mónica Pardo, Mónica Pardo, Mónica Pardo, Mónica Pardo, Marco Straccia, Marco Straccia, Marco Straccia, Marco Straccia, Marco Straccia, Silvia Ginés, Silvia Ginés, Silvia Ginés, Silvia Ginés, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Isabel Hernández, Belén Arranz, Josep M. Canals, Josep M. Canals, Josep M. Canals, Josep M. Canals, Josep M. Canals, Albert Giralt, Albert Giralt, Albert Giralt, Albert Giralt, Albert Giralt
Published 2020-05-01

Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons

by Laura López-Molina, Joaquín Fernández-Irigoyen, Carmen Cifuentes-Díaz, Jordi Alberch, Jean-Antoine Girault, Enrique Santamaría, Silvia Ginés, Albert Giralt
Published 2022-03-01

A human single-chain Fv intrabody preferentially targets amino-terminal huntingtin fragments in striatal models of Huntington's disease

by Todd W. Miller, Chun Zhou, Silvia Gines, Marcy E. MacDonald, Nicholas D. Mazarakis, Gillian P. Bates, James S. Huston, Anne Messer
Published 2005-06-01

The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice

by Marc Espina, Nadia Di Franco, Martina Brañas-Navarro, Irene Rodriguez Navarro, Veronica Brito, Laura Lopez-Molina, Carlos Costas-Insua, Manuel Guzmán, Silvia Ginés
Published 2023-08-01

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

by Albert Giralt, Veronica Brito, Quentin Chevy, Clémence Simonnet, Yo Otsu, Carmen Cifuentes-Díaz, Benoit de Pins, Renata Coura, Jordi Alberch, Sílvia Ginés, Jean-Christophe Poncer, Jean-Antoine Girault
Published 2017-05-01

IDENTIFYING VPS13A INTERACTING PARTNERS AND THEIR ROLE IN THE NEURONAL MITOCHONDRIAL FUNCTIONING IN A MODEL OF CHOREA-ACANTHOCYTOSIS

by Alba Ramon-Lainez, Esther García García, Daniel Del Toro, Georgia Escaramís, Laura Lopez Molina, L Valls, G Garrabou, Eulàlia Martí, Silvia Gines, Mercè Masana, Jordi Alberch, Manuel J Rodríguez
Published 2023-10-01

Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease

by Alice S. Chen-Plotkin, Ghazaleh Sadri-Vakili, George J. Yohrling, Melissa W. Braveman, Caroline L. Benn, Kelly E. Glajch, Derek P. DiRocco, Laurie A. Farrell, Dimitri Krainc, Silvia Gines, Marcy E. MacDonald, Jang-Ho J. Cha
Published 2006-05-01

Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease

by David Moreno-Delgado, Mar Puigdellívol, Estefanía Moreno, Mar Rodríguez-Ruiz, Joaquín Botta, Paola Gasperini, Anna Chiarlone, Lesley A Howell, Marco Scarselli, Vicent Casadó, Antoni Cortés, Sergi Ferré, Manuel Guzmán, Carmen Lluís, Jordi Alberch, Enric I Canela, Silvia Ginés, Peter J McCormick
Published 2020-06-01

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

by Manuel Daldin, Valentina Fodale, Cristina Cariulo, Lucia Azzollini, Margherita Verani, Paola Martufi, Maria Carolina Spiezia, Sean M. Deguire, Marta Cherubini, Douglas Macdonald, Andreas Weiss, Alberto Bresciani, Jean-Paul Gerard Vonsattel, Lara Petricca, J. Lawrence Marsh, Silvia Gines, Iolanda Santimone, Massimo Marano, Hilal A. Lashuel, Ferdinando Squitieri, Andrea Caricasole
Published 2017-07-01

Reversal of a Full-length Mutant Huntingtin Neuronal Cell Phenotype by Chemical Inhibitors of Polyglutamine-mediated Aggregation

by Wang, Jin, Gines, Silvia, MacDonald, Marcy Elizabeth, Gusella, James Francis
Published 2011