A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice

by Nuria Suelves, Lucy Kirkham-McCarthy, Robert S. Lahue, Silvia Ginés
Published 2017-07-01

PSGL-1 decorated with sialyl Lewisa/x promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement

by Michael O’Dwyer, Lucy Kirkham-McCarthy, Marina Cerreto, Robin Foà, Alessandro Natoni
Published 2024-01-01

Histone deacetylase complexes promote trinucleotide repeat expansions.

by Kim Debacker, Aisling Frizzell, Olive Gleeson, Lucy Kirkham-McCarthy, Tony Mertz, Robert S Lahue
Published 2012-02-01

Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model

by Alessandro Natoni, Mariah L. Farrell, Sophie Harris, Carolyne Falank, Lucy Kirkham-McCarthy, Matthew S. Macauley, Michaela R. Reagan, Michael O’Dwyer
Published 2020-02-01

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide

by Mark Gurney, Arwen Stikvoort, Emma Nolan, Lucy Kirkham-McCarthy, Stanislav Khoruzhenko, Rama Shivakumar, Sonja Zweegman, Niels W.C.J. van de Donk, Tuna Mutis, Eva Szegezdi, Subhashis Sarkar, Michael O’Dwyer
Published 2020-12-01

Sialofucosylation Enables Platelet Binding to Myeloma Cells via P-Selectin and Suppresses NK Cell-Mediated Cytotoxicity

by Alessandro Natoni, Marina Cerreto, Maria Stefania De Propris, Maria Teresa Petrucci, Francesca Fazio, Stefania Intoppa, Maria Laura Milani, Lucy Kirkham-McCarthy, Robert Henderson, Dawn Swan, Anna Guarini, Michael O’Dwyer, Robin Foà
Published 2023-04-01