Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells.

by Subhashis Sarkar, Wilfred T V Germeraad, Kasper M A Rouschop, Elisabeth M P Steeghs, Michel van Gelder, Gerard M J Bos, Lotte Wieten
Published 2013-01-01

NKG2A Expression Is Not per se Detrimental for the Anti-Multiple Myeloma Activity of Activated Natural Killer Cells in an In Vitro System Mimicking the Tumor Microenvironment

by Niken M. Mahaweni, Niken M. Mahaweni, Niken M. Mahaweni, Femke A. I. Ehlers, Femke A. I. Ehlers, Femke A. I. Ehlers, Subhashis Sarkar, Subhashis Sarkar, Johanna W. H. Janssen, Marcel G. J. Tilanus, Marcel G. J. Tilanus, Gerard M. J. Bos, Gerard M. J. Bos, Lotte Wieten, Lotte Wieten
Published 2018-06-01

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide

by Mark Gurney, Arwen Stikvoort, Emma Nolan, Lucy Kirkham-McCarthy, Stanislav Khoruzhenko, Rama Shivakumar, Sonja Zweegman, Niels W.C.J. van de Donk, Tuna Mutis, Eva Szegezdi, Subhashis Sarkar, Michael O’Dwyer
Published 2020-12-01

CD38-specific Chimeric Antigen Receptor Expressing Natural Killer KHYG-1 Cells: A Proof of Concept for an “Off the Shelf” Therapy for Multiple Myeloma

by Arwen Stikvoort, Jort van der Schans, Subhashis Sarkar, Renée Poels, Ruud Ruiter, Jyoti Naik, Huipin Yuan, Joost D. de Bruijn, Niels W. C. J. van de Donk, Sonja Zweegman, Maria Themeli, Richard Groen, Michael O’Dwyer, Tuna Mutis
Published 2021-07-01