Detection of innate immune response modulating impurities (IIRMI) in therapeutic peptides and proteins: Impact of excipients

by Seth G. Thacker, Cheng Her, Logan Kelley-Baker, Derek D C. Ireland, Mohanraj Manangeeswaran, Eric S. Pang, Daniela Verthelyi
Published 2022-09-01

CpG ODN D35 improves the response to abbreviated low-dose pentavalent antimonial treatment in non-human primate model of cutaneous leishmaniasis.

by Seth G Thacker, Ian L McWilliams, Beatrice Bonnet, Lydia Halie, Serge Beaucage, Swaksha Rachuri, Ranadhir Dey, Robert Duncan, Farrokh Modabber, Stephen Robinson, Graeme Bilbe, Byron Arana, Daniela Verthelyi
Published 2020-02-01

Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice[S]

by Seth G. Thacker, Xavier Rousset, Safiya Esmail, Abdalrahman Zarzour, Xueting Jin, Heidi L. Collins, Maureen Sampson, John Stonik, Stephen Demosky, Daniela A. Malide, Lita Freeman, Boris L. Vaisman, Howard S. Kruth, Steven J. Adelman, Alan T. Remaley
Published 2015-07-01

Lipoprotein X Causes Renal Disease in LCAT Deficiency.

by Alice Ossoli, Edward B Neufeld, Seth G Thacker, Boris Vaisman, Milton Pryor, Lita A Freeman, Christine A Brantner, Irina Baranova, Nicolás O Francone, Stephen J Demosky, Cecilia Vitali, Monica Locatelli, Mauro Abbate, Carlamaria Zoja, Guido Franceschini, Laura Calabresi, Alan T Remaley
Published 2016-01-01

BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein

by Mohanraj Manangeeswaran, Derek D. C. Ireland, Seth G. Thacker, Ha-Na Lee, Logan Kelley-Baker, Aaron P. Lewkowicz, Paul W. Rothlauf, Paul W. Rothlauf, Marjorie Cornejo Pontelli, Louis-Marie Bloyet, Michael A. Eckhaus, Mirian I. Mendoza, Sean Whelan, Daniela Verthelyi
Published 2022-07-01