399 Class I HLA-independent lysis of cancer cells by tumor-infiltrating CD8 T cells

by Nir Hacohen, Robert T Manguso, Russell W Jenkins, Moshe Sade-Feldman, Hongyan Xie, Aiping Jiang, Jonathan Perera
Published 2023-11-01

Protocol for in vivo CRISPR screening using selective CRISPR antigen removal lentiviral vectors

by Sarah Kate Lane-Reticker, Emily A. Kessler, Audrey J. Muscato, Sarah Y. Kim, John G. Doench, Kathleen B. Yates, Robert T. Manguso, Juan Dubrot
Published 2023-03-01

PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

by Yashaswi Shrestha, Michael Quigley, Travis Hughes, Robert T Manguso, Natalie B Collins, Rose Al Abosy, Brian C Miller, Kevin Bi, Qihong Zhao, Jeffrey J Ishizuka, Kathleen B Yates, Hans W Pope, Marc Wadsworth, Alex K Shalek, Jesse S Boehm, William C Hahn, John G Doench, W Nicholas Haining
Published 2022-03-01

561 Targeting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

by Nir Hacohen, Soldano Ferrone, Keith Flaherty, Tatyana Sharova, Genevieve M Boland, Robert T Manguso, Payal Tiwari, Debattama R Sen, Arnav Mehta, William Michaud, Or-Yam Revach, Angelina Cicerchia, Moshe Sade-Feldman, Seth Anderson, Boryana Petrova, Ofir Shorer, Lloyd Bod, Giulia Cattaneo, Hongyan Xie, Martin Rasmussen, Jacy Fang, Keren Yizhak, Naama Kanarek, Russell Jenkins
Published 2023-11-01

Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders

by Zhe Zhang, Yi Zhang, Fan Zhang, Xiaojing Ma, Ravindra Uppaluri, Robert Haddad, Jonathan D Schoenfeld, Shengqing Gu, Joshua Keegan, James A Lederer, Xiaoqing Wang, Zexian Zeng, Jingxin Fu, Liye Zhou, Ann Marie Egloff, Fei Guo, Katie M Campbell, Peter Du, Paul Zolkind, Rachel Riley, Yasutaka Nakahori, Obi Griffith, Robert T Manguso, X Shirley Liu
Published 2022-01-01

999 The PTPN2/N1 small molecule inhibitor ABBV-CLS-484 promotes NK cell activity driving primary tumor regression and preventing metastasis

by Chirag Patel, Meng Sun, Yue Liu, Jonathan Powell, Kyle Halliwill, Jennifer M Frost, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Keith M Hamel, Kira Olander, Kathleen A McGuire, Audrey J Muscato, Kelly Klinge, Joseph Klahn, Jacqueline Aguado, Payal Tiwari, Kayla J Colvin, Marcia N Paddock, Philip R Kym, Omar Avila-Monge, Alexander Schutte
Published 2023-11-01

Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening

by Azucena Ramos, Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger, Taeyoon Kyung, Keene L. Abbott, Julia Fröse, Daniel Goulet, Khloe S. Gordon, Keith P. Eidell, Paul Leclerc, Charles A. Whittaker, Rebecca C. Larson, Audrey J. Muscato, Kathleen B. Yates, Juan Dubrot, John G. Doench, Aviv Regev, Matthew G. Vander Heiden, Marcela V. Maus, Robert T. Manguso, Michael E. Birnbaum, Michael T. Hemann
Published 2023-12-01

1403-A PTPN2/N1 inhibitor ABBV-CLS-484 unleashes potent anti-tumor immunity

by Wei Qiu, Qi Sun, Yi Yang, Chirag Patel, Meng Sun, Yue Liu, Kyle Halliwill, Sarah Kim, Rebecca Mathew, Jennifer M Frost, Jennifer A Roth, Domenick Kennedy, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Arvin Iracheta-Vellve, Keith M Hamel, Kira Olander, Thomas GR Davis, Kathleen A McGuire, Geoff T Halvorsen, Omar I Avila, Ashwin V Kammula, Audrey J Muscato, Prasanthi Geda, Kelly Klinge, Zhaoming Xiong, Ryan Duggan, Liang Mu, Mitchell D Yeary, James C Patti, Tyler M Balon, Carey Backus, Angeline Chen, Kenton Longenecker, Joseph Klahn, Cara Hrusch, Navasona Krishnan, Charles W Hutchins, Jacqueline Aguado, Marinka Bulic, Payal Tiwari, Kayla J Colvin, Cun Lan Chuong, Ian C Kohnle, Matthew G Rees, Andrew Boghossian, Melissa Ronan, Meng-Ju Wu, Debattama R Sen, Gabriel K Griffin, Nabeel El-Bardeesy, Patricia Trusk, Joshua H Decker, Stacey Fossey, Marcia N Paddock, Elliot P Farney, Clay Beauregard, Philip R Kym
Published 2023-11-01

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

by Juneja, Vikram R., McGuire, Kathleen A., Manguso, Robert T., LaFleur, Martin W., Collins, Natalie, Haining, W. Nicholas, Freeman, Gordon J., Sharpe, Arlene H.
Published 2017