A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies

by Xun Chen, Matteo Gentili, Nir Hacohen, Aviv Regev
Published 2021-09-01

MAUDE: inferring expression changes in sorting-based CRISPR screens

by Carl G. de Boer, John P. Ray, Nir Hacohen, Aviv Regev
Published 2020-06-01

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

by Yuk Yuen Lan, Diana Londoño, Richard Bouley, Michael S. Rooney, Nir Hacohen
Published 2014-10-01

564 Single-cell transcriptomic analysis of immune compartments following combination immunotherapy treatment in poorly immunogenic tumors

by Nir Hacohen, Shuqiang Li, Darrell Irvine, Ang Cui, Kelly Moynihan, Chensu Wang, Jackson Southard
Published 2021-11-01

TGF-β suppresses β-catenin-dependent tolerogenic activation program in dendritic cells.

by Bryan Vander Lugt, Zachary T Beck, Robert C Fuhlbrigge, Nir Hacohen, James J Campbell, Marianne Boes
Published 2011-01-01

509 The localization of novel macrophage subsets in class III and IV lupus nephritis kidney sections

by Nir Hacohen, ANNE DAVIDSON, Paul J Hoover, Michael Peters, Tony Jones, Jeff Hodgin, Jon Chen
Published 2021-11-01

399 Class I HLA-independent lysis of cancer cells by tumor-infiltrating CD8 T cells

by Nir Hacohen, Robert T Manguso, Russell W Jenkins, Moshe Sade-Feldman, Hongyan Xie, Aiping Jiang, Jonathan Perera
Published 2023-11-01

920 A single-cell spatially resolved MERFISH map of the colorectal tumor immune microenvironment

by Jonathan Chen, Nir Hacohen, Jiang He, Genevieve Boland, Karin Pelka, Colles Price, Sherry Chao, George Emanuel
Published 2021-11-01

Protocol for bulk RNA sequencing of enriched human neutrophils from whole blood and estimation of sample purity

by Anna L.K. Gonye, Thomas J. LaSalle, Samuel S. Freeman, Miguel Reyes, Nir Hacohen, Alexandra-Chloé Villani, Moshe Sade-Feldman
Published 2023-03-01

641 Spatially organized multicellular immune hubs in MMRd and MMRp colorectal cancer

by Jonathan Chen, Ana Anderson, Nir Hacohen, Genevieve Boland, Marios Giannakis, Aviv Regev, Karin Pelka, Matan Hofree, Andrew Aguirre, Orit Rozenblatt-Rosen
Published 2021-11-01

152 Immuno-oncology protein biomarker panels provide greater biological insights and improved patient stratification

by Nir Hacohen, Keith Flaherty, Ryan Sullivan, Genevieve M Boland, Marijana Rucevic, Arnav Mehta, Katarina Horneaus, Emmett Sprecher, Alexis Schneider, Russell W Jenkins, William Michaud, Benchun Miao
Published 2023-11-01

Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells.

by Sylvie Rato, Sara Maia, Paula M Brito, Leonor Resende, Carina F Pereira, Catarina Moita, Rui P Freitas, José Moniz-Pereira, Nir Hacohen, Luis Ferreira Moita, Joao Goncalves
Published 2010-02-01

An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion.

by Pedro Moura-Alves, Ana Neves-Costa, Helena Raquel, Teresa Raquel Pacheco, Bruno D'Almeida, Raquel Rodrigues, Iris Cadima-Couto, Ângelo Chora, Mariana Oliveira, Margarida Gama-Carvalho, Nir Hacohen, Luis F Moita
Published 2011-01-01

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

by Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah Dele-Oni, Marc A. Schwartz, Rebecca J. Carlson, Aziz M. Al’Khafaji, Karsten Krug, Adam Brown, John G. Doench, Steven A. Carr, Nir Hacohen
Published 2023-02-01

An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling

by Philipp Mertins, Dariusz Przybylski, Nir Yosef, Jana Qiao, Karl Clauser, Raktima Raychowdhury, Thomas M. Eisenhaure, Tanja Maritzen, Volker Haucke, Takashi Satoh, Shizuo Akira, Steven A. Carr, Aviv Regev, Nir Hacohen, Nicolas Chevrier
Published 2017-06-01

The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.

by Claire Marie Filone, Ignacio S Caballero, Ken Dower, Marc L Mendillo, Glenn S Cowley, Sandro Santagata, Daniel K Rozelle, Judy Yen, Kathleen H Rubins, Nir Hacohen, David E Root, Lisa E Hensley, John Connor
Published 2014-02-01

SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint

by Emma Hajaj, Galit Eisenberg, Shiri Klein, Shoshana Frankenburg, Sharon Merims, Inna Ben David, Thomas Eisenhaure, Sarah E Henrickson, Alexandra Chloé Villani, Nir Hacohen, Nathalie Abudi, Rinat Abramovich, Jonathan E Cohen, Tamar Peretz, Andre Veillette, Michal Lotem
Published 2020-03-01

Immune receptor repertoires in pediatric and adult acute myeloid leukemia

by Jian Zhang, Xihao Hu, Jin Wang, Avinash Das Sahu, David Cohen, Li Song, Zhangyi Ouyang, Jingyu Fan, Binbin Wang, Jingxin Fu, Shengqing Gu, Moshe Sade-Feldman, Nir Hacohen, Wuju Li, Xiaomin Ying, Bo Li, X. Shirley Liu
Published 2019-11-01

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

by John P. Ray, Carl G. de Boer, Charles P. Fulco, Caleb A. Lareau, Masahiro Kanai, Jacob C. Ulirsch, Ryan Tewhey, Leif S. Ludwig, Steven K. Reilly, Drew T. Bergman, Jesse M. Engreitz, Robbyn Issner, Hilary K. Finucane, Eric S. Lander, Aviv Regev, Nir Hacohen
Published 2020-03-01

1255 Single cell dissection of human checkpoint inhibitor hepatitis reveals insights into liver immune tolerance

by Nir Hacohen, Ryan Sullivan, Molly Thomas, John McGuire, Dejan Juric, Leyre Zubiri, Kerry Reynolds, Genevieve M Boland, Alexandra-Chloe Villani, Mazen Nasrallah, Neal Smith, Kasidet Manakongtreecheep, Jessica Tantivit, Alice Tirard, Swetha Ramesh, Tos Chan, Marc Sherman, Georg Lauer, Shreyash Sonthalia
Published 2023-11-01