pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels.

by Paul Geeleher, Nancy Cox, R Stephanie Huang
Published 2014-01-01

Random-effects meta-analysis of effect sizes as a unified framework for gene set analysis.

by Mohammad A Makrooni, Dónal O'Shea, Paul Geeleher, Cathal Seoighe
Published 2022-10-01

Integrative "omic" analysis for tamoxifen sensitivity through cell based models.

by Liming Weng, Dana Ziliak, Bonnie Lacroix, Paul Geeleher, R Stephanie Huang
Published 2014-01-01

Facilitating Drug Discovery in Breast Cancer by Virtually Screening Patients Using In Vitro Drug Response Modeling

by Robert F. Gruener, Alexander Ling, Ya-Fang Chang, Gladys Morrison, Paul Geeleher, Geoffrey L. Greene, R. Stephanie Huang
Published 2021-02-01

Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity

by Paul Geeleher, Aritro Nath, Fan Wang, Zhenyu Zhang, Alvaro N. Barbeira, Jessica Fessler, Robert L. Grossman, Cathal Seoighe, R. Stephanie Huang
Published 2018-09-01

A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics

by Hyeong-Min Lee, William C. Wright, Min Pan, Jonathan Low, Duane Currier, Jie Fang, Shivendra Singh, Stephanie Nance, Ian Delahunty, Yuna Kim, Richard H. Chapple, Yinwen Zhang, Xueying Liu, Jacob A. Steele, Jun Qi, Shondra M. Pruett-Miller, John Easton, Taosheng Chen, Jun Yang, Adam D. Durbin, Paul Geeleher
Published 2023-11-01

An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs

by Richard H. Chapple, Xueying Liu, Sivaraman Natarajan, Margaret I. M. Alexander, Yuna Kim, Anand G. Patel, Christy W. LaFlamme, Min Pan, William C. Wright, Hyeong-Min Lee, Yinwen Zhang, Meifen Lu, Selene C. Koo, Courtney Long, John Harper, Chandra Savage, Melissa D. Johnson, Thomas Confer, Walter J. Akers, Michael A. Dyer, Heather Sheppard, John Easton, Paul Geeleher
Published 2024-06-01

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

by Min Pan, William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder, Brandt C. Huddle, Jonathan Low, Kaley B. Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel W. Brady, Sivaraman Natarajan, Matthew J. Posgai, John Schuetz, Darcie Miller, Ravi Kalathur, Siquan Chen, Jon Patrick Connelly, M. Madan Babu, Michael A. Dyer, Shondra M. Pruett-Miller, Burgess B. Freeman, Taosheng Chen, Lucy A. Godley, Scott C. Blanchard, Elizabeth Stewart, John Easton, Paul Geeleher
Published 2021-11-01