Surgical Strikes on Host Defenses: Role of the Viral Protease Activity in Innate Immune Antagonism

by Chue Vin Chin, Mohsan Saeed
Published 2022-04-01

SARS-CoV-2 nonstructural protein 6 from Alpha to Omicron: evolution of a transmembrane protein

by Shuchen Feng, Amornrat O'Brien, Da-Yuan Chen, Mohsan Saeed, Susan C. Baker
Published 2023-08-01

NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus

by Shafi Kuchay, Mohsan Saeed, Carlotta Giorgi, Jie Li, Hans-Heinrich Hoffmann, Paolo Pinton, Charles M. Rice, Michele Pagano
Published 2018-10-01

Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication

by Lin Lin, Da-Yuan Chen, Christina Scartelli, Huanzhang Xie, Glenn Merrill-Skoloff, Moua Yang, Lijun Sun, Mohsan Saeed, Robert Flaumenhaft
Published 2023-09-01

DNA templates with blocked long 3ʹ end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci

by Saptaparni Bandyopadhyay, Joseph Douglass, Sebastian Kapell, Nazimuddin Khan, Fabiana Feitosa-Suntheimer, Jenny A Klein, Jasmine Temple, Jayce Brown-Culbertson, Alexander H Tavares, Mohsan Saeed, Nelson C Lau
Published 2021-05-01

The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication

by Madeline Loffredo, Hector Lucero, Da-Yuan Chen, Aoife O’Connell, Simon Bergqvist, Ahmad Munawar, Asanga Bandara, Steff De Graef, Stephen D. Weeks, Florian Douam, Mohsan Saeed, Ali H. Munawar
Published 2021-03-01

HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses

by Shira Weingarten-Gabbay, Leah R. Pearlman, Da-Yuan Chen, Susan Klaeger, Hannah B. Taylor, Nicole L. Welch, Derin B. Keskin, Steven A. Carr, Jennifer G. Abelin, Mohsan Saeed, Pardis C. Sabeti
Published 2022-12-01

Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus

by Dandan Liu, Philip R. Tedbury, Shuiyun Lan, Andrew D. Huber, Maritza N. Puray-Chavez, Juan Ji, Eleftherios Michailidis, Mohsan Saeed, Tanyaradzwa P. Ndongwe, Leda C. Bassit, Raymond F. Schinazi, Robert Ralston, Charles M. Rice, Stefan G. Sarafianos
Published 2019-11-01

Identification, Molecular Cloning, and Analysis of Full-Length Hepatitis C Virus Transmitted/Founder Genotypes 1, 3, and 4

by Mark B. Stoddard, Hui Li, Shuyi Wang, Mohsan Saeed, Linda Andrus, Wenge Ding, Xinpei Jiang, Gerald H. Learn, Markus von Schaewen, Jessica Wen, Paul A. Goepfert, Beatrice H. Hahn, Alexander Ploss, Charles M. Rice, George M. Shaw
Published 2015-05-01

Defining the proteolytic landscape during enterovirus infection.

by Mohsan Saeed, Sebastian Kapell, Nicholas T Hertz, Xianfang Wu, Kierstin Bell, Alison W Ashbrook, Milica Tesic Mark, Henry A Zebroski, Maxwell L Neal, Malin Flodström-Tullberg, Margaret R MacDonald, John D Aitchison, Henrik Molina, Charles M Rice
Published 2020-09-01

The HLA-II immunopeptidome of SARS-CoV-2

by Shira Weingarten-Gabbay, Da-Yuan Chen, Siranush Sarkizova, Hannah B. Taylor, Matteo Gentili, Gabrielle M. Hernandez, Leah R. Pearlman, Matthew R. Bauer, Charles M. Rice, Karl R. Clauser, Nir Hacohen, Steven A. Carr, Jennifer G. Abelin, Mohsan Saeed, Pardis C. Sabeti
Published 2024-01-01

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

by David W Sanders, Chanelle C Jumper, Paul J Ackerman, Dan Bracha, Anita Donlic, Hahn Kim, Devin Kenney, Ivan Castello-Serrano, Saori Suzuki, Tomokazu Tamura, Alexander H Tavares, Mohsan Saeed, Alex S Holehouse, Alexander Ploss, Ilya Levental, Florian Douam, Robert F Padera, Bruce D Levy, Clifford P Brangwynne
Published 2021-04-01

Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection

by Liuliu Yang, Yuling Han, Ting Zhou, Lauretta A. Lacko, Mohsan Saeed, Christina Tan, Ron Danziger, Jiajun Zhu, Zeping Zhao, Clare Cahir, Alice Maria Giani, Yang Li, Xue Dong, Dorota Moroziewicz, Daniel Paull, Zhengming Chen, Aaron Zhong, Scott A. Noggle, Charles M. Rice, Qibin Qi, Todd Evans, Shuibing Chen
Published 2023-07-01

Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus

by Da-Yuan Chen, Jacquelyn Turcinovic, Shuchen Feng, Devin J. Kenney, Chue Vin Chin, Manish C. Choudhary, Hasahn L. Conway, Marc Semaan, Brianna J. Close, Alexander H. Tavares, Scott Seitz, Nazimuddin Khan, Sebastian Kapell, Nicholas A. Crossland, Jonathan Z. Li, Florian Douam, Susan C. Baker, John H. Connor, Mohsan Saeed
Published 2023-05-01

Male germ cells support long-term propagation of Zika virus

by Christopher L. Robinson, Angie C. N. Chong, Alison W. Ashbrook, Ginnie Jeng, Julia Jin, Haiqi Chen, Elizabeth I. Tang, Laura A. Martin, Rosa S. Kim, Reyn M. Kenyon, Eileen Do, Joseph M. Luna, Mohsan Saeed, Lori Zeltser, Harold Ralph, Vanessa L. Dudley, Marc Goldstein, Charles M. Rice, C. Yan Cheng, Marco Seandel, Shuibing Chen
Published 2018-05-01

Stem cell-derived polarized hepatocytes

by Viet Loan Dao Thi, Xianfang Wu, Rachel L. Belote, Ursula Andreo, Constantin N. Takacs, Joseph P. Fernandez, Luis Andre Vale-Silva, Sarah Prallet, Charlotte C. Decker, Rebecca M. Fu, Bingqian Qu, Kunihiro Uryu, Henrik Molina, Mohsan Saeed, Eike Steinmann, Stephan Urban, Roshni R. Singaraja, William M. Schneider, Sanford M. Simon, Charles M. Rice
Published 2020-04-01

Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression

by Mariano Carossino, Devin Kenney, Aoife K. O’Connell, Paige Montanaro, Anna E. Tseng, Hans P. Gertje, Kyle A. Grosz, Maria Ericsson, Bertrand R. Huber, Susanna A. Kurnick, Saravanan Subramaniam, Thomas A. Kirkland, Joel R. Walker, Kevin P. Francis, Alexander D. Klose, Neal Paragas, Markus Bosmann, Mohsan Saeed, Udeni B. R. Balasuriya, Florian Douam, Nicholas A. Crossland
Published 2022-03-01

A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction

by Monir Ejemel, Qi Li, Shurong Hou, Zachary A. Schiller, Julia A. Tree, Aaron Wallace, Alla Amcheslavsky, Nese Kurt Yilmaz, Karen R. Buttigieg, Michael J. Elmore, Kerry Godwin, Naomi Coombes, Jacqueline R. Toomey, Ryan Schneider, Anudeep S. Ramchetty, Brianna J. Close, Da-Yuan Chen, Hasahn L. Conway, Mohsan Saeed, Chandrashekar Ganesa, Miles W. Carroll, Lisa A. Cavacini, Mark S. Klempner, Celia A. Schiffer, Yang Wang
Published 2020-08-01

A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates

by Jennifer R. Keeffe, Koen K.A. Van Rompay, Priscilla C. Olsen, Qiao Wang, Anna Gazumyan, Stephanie A. Azzopardi, Dennis Schaefer-Babajew, Yu E. Lee, Jackson B. Stuart, Anil Singapuri, Jennifer Watanabe, Jodie Usachenko, Amir Ardeshir, Mohsan Saeed, Marianna Agudelo, Thomas Eisenreich, Stylianos Bournazos, Thiago Y. Oliveira, Charles M. Rice, Lark L. Coffey, Margaret R. MacDonald, Pamela J. Bjorkman, Michel C. Nussenzweig, Davide F. Robbiani
Published 2018-11-01