Neurodevelopment in Down syndrome: Concordance in humans and models

by Jenny A. Klein, Tarik F. Haydar, Tarik F. Haydar
Published 2022-07-01

Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome

by Zhen Li, Jenny A. Klein, Jenny A. Klein, Sanjeev Rampam, Ronni Kurzion, Natalie Baker Campbell, Yesha Patel, Yesha Patel, Tarik F. Haydar, Ella Zeldich
Published 2022-09-01

Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome

by Patricia R. Shaw, Jenny A. Klein, Nadine M. Aziz, Tarik F. Haydar
Published 2020-09-01

Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21

by Jenny A. Klein, Jenny A. Klein, Zhen Li, Sanjeev Rampam, Jack Cardini, Amara Ayoub, Patricia Shaw, Angela L. Rachubinski, Angela L. Rachubinski, Joaquin M. Espinosa, Joaquin M. Espinosa, Ella Zeldich, Tarik F. Haydar
Published 2022-01-01

Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome

by Nadine M. Aziz, Jenny A. Klein, Morgan R. Brady, Jose Luis Olmos-Serrano, Vittorio Gallo, Tarik F. Haydar
Published 2019-12-01

DNA templates with blocked long 3ʹ end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci

by Saptaparni Bandyopadhyay, Joseph Douglass, Sebastian Kapell, Nazimuddin Khan, Fabiana Feitosa-Suntheimer, Jenny A Klein, Jasmine Temple, Jayce Brown-Culbertson, Alexander H Tavares, Mohsan Saeed, Nelson C Lau
Published 2021-05-01

High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly

by Martin H Berryer, Gizem Rizki, Anna Nathanson, Jenny A Klein, Darina Trendafilova, Sara G Susco, Daisy Lam, Angelica Messana, Kristina M Holton, Kyle W Karhohs, Beth A Cimini, Kathleen Pfaff, Anne E Carpenter, Lee L Rubin, Lindy E Barrett
Published 2023-04-01

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells

by Martin H. Berryer, Matthew Tegtmeyer, Loïc Binan, Vera Valakh, Anna Nathanson, Darina Trendafilova, Ethan Crouse, Jenny A. Klein, Daniel Meyer, Olli Pietiläinen, Francesca Rapino, Samouil L. Farhi, Lee L. Rubin, Steven A. McCarroll, Ralda Nehme, Lindy E. Barrett
Published 2023-07-01