Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy, and tumor-targeting S. typhimurium A1-R is superior to first-line chem...

by Miyake, Kentaro, Kiyuna, Tasuku, Miyake, Masuyo, Kawaguchi, Kei, Yoon, Sang Nam, Zhang, Zhiying, Igarashi, Kentaro, Razmjooei, Sahar, Wangsiricharoen, Sintawat, Murakami, Takashi, Li, Yunfeng, Nelson, Scott D, Russell, Tara A, Singh, Arun S, Hiroshima, Yukihiko, Momiyama, Masashi, Matsuyama, Ryusei, Chishima, Takashi, Singh, Shree Ram, Endo, Itaru, Eilber, Fritz C, Hoffman, Robert M
Published 2018

A novel patient-derived orthotopic xenograft (PDOX) mouse model of highly-aggressive liver metastasis for identification of candidate effective drug-combinations.

by Zhang, Zhiying, Hu, Kaiwen, Miyake, Kentaro, Kiyuna, Tasuku, Oshiro, Hiromichi, Wangsiricharoen, Sintawat, Kawaguchi, Kei, Higuchi, Takashi, Razmjooei, Sahar, Miyake, Masuyo, Chawla, Sant P, Singh, Shree Ram, Hoffman, Robert M
Published 2020

Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models.

by Kawaguchi, Kei, Han, Qinghong, Li, Shukuan, Tan, Yuying, Igarashi, Kentaro, Miyake, Kentaro, Kiyuna, Tasuku, Miyake, Masuyo, Chemielwski, Bartosz, Nelson, Scott D, Russell, Tara A, Dry, Sarah M, Li, Yunfeng, Singh, Arun S, Eckardt, Mark A, Unno, Michiaki, Eilber, Fritz C, Hoffman, Robert M
Published 2018

Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations.

by Miyake, Kentaro, Kawaguchi, Kei, Miyake, Masuyo, Zhao, Ming, Kiyuna, Tasuku, Igarashi, Kentaro, Zhang, Zhiying, Murakami, Takashi, Li, Yunfeng, Nelson, Scott D, Bouvet, Michael, Elliott, Irmina, Russell, Tara A, Singh, Arun S, Hiroshima, Yukihiko, Momiyama, Masashi, Matsuyama, Ryusei, Chishima, Takashi, Singh, Shree Ram, Endo, Itaru, Eilber, Fritz C, Hoffman, Robert M
Published 2018

Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model.

by Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Miyake, Kentaro, Miyake, Masuyo, Li, Yunfeng, Nelson, Scott D, Dry, Sarah M, Singh, Arun S, Elliott, Irmina A, Russell, Tara A, Eckardt, Mark A, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Tsuchiya, Hiroyuki, Eilber, Fritz C, Hoffman, Robert M
Published 2018

Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mou...

by Igarashi, Kentaro, Kawaguchi, Kei, Zhao, Ming, Kiyuna, Tasuku, Miyake, Kentaro, Miyake, Masuyo, Nelson, Scott D, Dry, Sarah M, Li, Yunfeng, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Higuchi, Takashi, Singh, Shree Ram, Tsuchiya, Hiroyuki, Hoffman, Robert M
Published 2020

Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model.

by Kiyuna, Tasuku, Tome, Yasunori, Murakami, Takashi, Kawaguchi, Kei, Igarashi, Kentaro, Miyake, Kentaro, Miyake, Masuyo, Li, Yunfeng, Nelson, Scott D, Dry, Sarah M, Singh, Arun S, Russell, Tara A, Elliott, Irmina, Singh, Shree Ram, Kanaya, Fuminori, Eilber, Fritz C, Hoffman, Robert M
Published 2018

Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model.

by Igarashi, Kentaro, Kawaguchi, Kei, Li, Shukuan, Han, Qinghong, Tan, Yuying, Gainor, Emily, Kiyuna, Tasuku, Miyake, Kentaro, Miyake, Masuyo, Higuchi, Takashi, Oshiro, Hiromichi, Singh, Arun S, Eckardt, Mark A, Nelson, Scott D, Russell, Tara A, Dry, Sarah M, Li, Yunfeng, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Tsuchiya, Hiroyuki, Eilber, Fritz C, Hoffman, Robert M
Published 2018

The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing's sarcoma with a FUS-ER...

by Miyake, Kentaro, Murakami, Takashi, Kiyuna, Tasuku, Igarashi, Kentaro, Kawaguchi, Kei, Miyake, Masuyo, Li, Yunfeng, Nelson, Scott D, Dry, Sarah M, Bouvet, Michael, Elliott, Irmina A, Russell, Tara A, Singh, Arun S, Eckardt, Mark A, Hiroshima, Yukihiko, Momiyama, Masashi, Matsuyama, Ryusei, Chishima, Takashi, Endo, Itaru, Eilber, Fritz C, Hoffman, Robert M
Published 2017

Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models.

by Kawaguchi, Kei, Igarashi, Kentaro, Li, Shukuan, Han, Qinghong, Tan, Yuying, Miyake, Kentaro, Kiyuna, Tasuku, Miyake, Masuyo, Murakami, Takashi, Chmielowski, Bartosz, Nelson, Scott D, Russell, Tara A, Dry, Sarah M, Li, Yunfeng, Unno, Michiaki, Eilber, Fritz C, Hoffman, Robert M
Published 2018