CoVaccine HT™ Adjuvant Potentiates Robust Immune Responses to Recombinant SARS-CoV-2 Spike S1 Immunization

by Brien K. Haun, Brien K. Haun, Chih-Yun Lai, Caitlin A. Williams, Teri Ann S. Wong, Michael M. Lieberman, Laurent Pessaint, Hanne Andersen, Axel T. Lehrer, Axel T. Lehrer
Published 2020-10-01

Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT™ adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice

by Chih-Yun Lai, Albert To, Teri Ann S. Wong, Michael M. Lieberman, David E. Clements, James T. Senda, Aquena H. Ball, Laurent Pessaint, Hanne Andersen, Wakako Furuyama, Andrea Marzi, Oreola Donini, Axel T. Lehrer
Published 2021-12-01

One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunization

by Maggie Gu, Jonathan L. Torres, Yijia Li, Alex Van Ry, Jack Greenhouse, Shannon Wallace, Chi-I Chiang, Laurent Pessaint, Abigail M. Jackson, Maciel Porto, Swagata Kar, Yuxing Li, Andrew B. Ward, Yimeng Wang
Published 2021-01-01

Preclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2

by Ria Lassaunière, Charlotta Polacek, Gregers J. Gram, Anders Frische, Jeanette Linnea Tingstedt, Maren Krüger, Brigitte G. Dorner, Anthony Cook, Renita Brown, Tatyana Orekov, Tammy Putmon-Taylor, Tracey-Ann Campbell, Jack Greenhouse, Laurent Pessaint, Hanne Andersen, Mark G. Lewis, Anders Fomsgaard
Published 2021-12-01

Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques.

by Margherita Rosati, Mahesh Agarwal, Xintao Hu, Santhi Devasundaram, Dimitris Stellas, Bhabadeb Chowdhury, Jenifer Bear, Robert Burns, Duncan Donohue, Laurent Pessaint, Hanne Andersen, Mark G Lewis, Evangelos Terpos, Meletios Athanasios Dimopoulos, Alexander Wlodawer, James I Mullins, David J Venzon, George N Pavlakis, Barbara K Felber
Published 2021-09-01

Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

by Mariana F. Tioni, Robert Jordan, Angie Silva Pena, Aditya Garg, Danlu Wu, Shannon I. Phan, Christopher M. Weiss, Xing Cheng, Jack Greenhouse, Tatyana Orekov, Daniel Valentin, Swagata Kar, Laurent Pessaint, Hanne Andersen, Christopher C. Stobart, Melissa H. Bloodworth, R. Stokes Peebles, Yang Liu, Xuping Xie, Pei-Yong Shi, Martin L. Moore, Roderick S. Tang
Published 2022-07-01

Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques

by Yongjun Sui, Jianping Li, Roushu Zhang, Sunaina Kiran Prabhu, Hanne Andersen, David Venzon, Anthony Cook, Renita Brown, Elyse Teow, Jason Velasco, Jack Greenhouse, Tammy Putman-Taylor, Tracey-Ann Campbell, Laurent Pessaint, Ian N. Moore, Laurel Lagenaur, Jim Talton, Matthew W. Breed, Josh Kramer, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Mark G. Lewis, Lai-Xi Wang, Jay A. Berzofsky
Published 2021-05-01

Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26.CoV2.S vaccine study in nonhuman primates.

by Daniel Y Zhu, Matthew J Gorman, Dansu Yuan, Jingyou Yu, Noe B Mercado, Katherine McMahan, Erica N Borducchi, Michelle Lifton, Jinyan Liu, Felix Nampanya, Shivani Patel, Lauren Peter, Lisa H Tostanoski, Laurent Pessaint, Alex Van Ry, Brad Finneyfrock, Jason Velasco, Elyse Teow, Renita Brown, Anthony Cook, Hanne Andersen, Mark G Lewis, Douglas A Lauffenburger, Dan H Barouch, Galit Alter
Published 2022-05-01

Immune Responses of a Novel Bi-Cistronic SARS-CoV-2 DNA Vaccine Following Intradermal Immunization With Suction Delivery

by Moonsup Jeong, Sagar B. Kudchodkar, Areum Gil, Bohyun Jeon, Gee Ho Park, Youngran Cho, Hyojin Lee, Mi Sun Cheong, Wonil Kim, Yun-Ho Hwang, Jung-Ah Lee, Heeji Lim, Mi Young Kim, Emran O. Lallow, Tej Brahmbhatt, Stephen A. Kania, Nandita C. Jhumur, Jerry W. Shan, Jeffrey D. Zahn, David I. Shreiber, Jonathan P. Singer, Hao Lin, Erin K. Spiegel, Laurent Pessaint, Maciel Porto, Alex Van Ry, Danielle Nase, Swagata Kar, Hanne Andersen, Ian Tietjen, Joel Cassel, Joseph M. Salvino, Luis J. Montaner, Young K. Park, Kar Muthumani, Christine C. Roberts, Joel N. Maslow
Published 2022-05-01

Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model

by Ami Patel, Jewell N. Walters, Emma L. Reuschel, Katherine Schultheis, Elizabeth Parzych, Ebony N. Gary, Igor Maricic, Mansi Purwar, Zeena Eblimit, Susanne N. Walker, Diana Guimet, Pratik Bhojnagarwala, Opeyemi S. Adeniji, Arthur Doan, Ziyang Xu, Dustin Elwood, Sophia M. Reeder, Laurent Pessaint, Kevin Y. Kim, Anthony Cook, Neethu Chokkalingam, Brad Finneyfrock, Edgar Tello-Ruiz, Alan Dodson, Jihae Choi, Alison Generotti, John Harrison, Nicholas J. Tursi, Viviane M. Andrade, Yaya Dia, Faraz I. Zaidi, Hanne Andersen, Mohamed Abdel-Mohsen, Mark G. Lewis, Kar Muthumani, J. Joseph Kim, Daniel W. Kulp, Laurent M. Humeau, Stephanie J. Ramos, Trevor R.F. Smith, David B. Weiner, Kate E. Broderick
Published 2021-10-01