Structural investigations of proteins encoded by SARS‐CoV‐2

by Alexander Wlodawer
Published 2022-09-01

An open chat with…Alexander Wlodawer

by Ioannis Tsagakis, Alexander Wlodawer
Published 2022-09-01

Structural analysis and molecular substrate recognition properties of Arabidopsis thaliana ornithine transcarbamylase, the molecular target of phaseolotoxin produced by Pseudomonas...

by Maciej Nielipinski, Agnieszka J. Pietrzyk-Brzezinska, Alexander Wlodawer, Bartosz Sekula
Published 2023-12-01

Avoidable errors in deposited macromolecular structures: an impediment to efficient data mining

by Zbigniew Dauter, Alexander Wlodawer, Wladek Minor, Mariusz Jaskolski, Bernhard Rupp
Published 2014-05-01

Generalized enzymatic mechanism of catalysis by tetrameric l-asparaginases from mesophilic bacteria

by Pawel Strzelczyk, Di Zhang, Marzena Dyba, Alexander Wlodawer, Jacek Lubkowski
Published 2020-10-01

The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of <italic toggle="yes">Vibrio cholerae</italic> Chromosome 2

by Jyoti K. Jha, Mi Li, Rodolfo Ghirlando, Lisa M. Miller Jenkins, Alexander Wlodawer, Dhruba Chattoraj
Published 2017-05-01

Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding.

by Jill Glesner, Sabina Wünschmann, Mi Li, Alla Gustchina, Alexander Wlodawer, Martin Himly, Martin D Chapman, Anna Pomés
Published 2011-01-01

Crystallographic models of SARS-CoV-2 3CLpro: in-depth assessment of structure quality and validation

by Mariusz Jaskolski, Zbigniew Dauter, Ivan G. Shabalin, Miroslaw Gilski, Dariusz Brzezinski, Marcin Kowiel, Bernhard Rupp, Alexander Wlodawer
Published 2021-03-01

New insights into structural and functional relationships between LonA proteases and ClpB chaperones

by Tatyana V. Rotanova, Anna G. Andrianova, Arsen M. Kudzhaev, Mi Li, Istvan Botos, Alexander Wlodawer, Alla Gustchina
Published 2019-09-01

Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery

by Vandana Mishra, Anuradha Deshmukh, Ishan Rathore, Satadru Chakraborty, Swati Patankar, Alla Gustchina, Alexander Wlodawer, Rickey Y. Yada, Prasenjit Bhaumik
Published 2024-01-01

RC1339/APRc from Rickettsia conorii is a novel aspartic protease with properties of retropepsin-like enzymes.

by Rui Cruz, Pitter Huesgen, Sean P Riley, Alexander Wlodawer, Carlos Faro, Christopher M Overall, Juan J Martinez, Isaura Simões
Published 2014-08-01

Crystal structures of a plant trypsin inhibitor from Enterolobium contortisiliquum (EcTI) and of its complex with bovine trypsin.

by Dongwen Zhou, Yara A Lobo, Isabel F C Batista, Rafael Marques-Porto, Alla Gustchina, Maria L V Oliva, Alexander Wlodawer
Published 2013-01-01

The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms

by Hannes M. Beyer, Salla I. Virtanen, A. Sesilja Aranko, Kornelia M. Mikula, George T. Lountos, Alexander Wlodawer, O. H. Samuli Ollila, Hideo Iwaï
Published 2020-11-01

Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41.

by Elena Gustchina, Mi Li, Rodolfo Ghirlando, Peter Schuck, John M Louis, Jason Pierson, Prashant Rao, Sriram Subramaniam, Alla Gustchina, G Marius Clore, Alexander Wlodawer
Published 2013-01-01

Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41.

by Elena Gustchina, Mi Li, John M Louis, D Eric Anderson, John Lloyd, Christian Frisch, Carole A Bewley, Alla Gustchina, Alexander Wlodawer, G Marius Clore
Published 2010-11-01

Structural Studies Reveal the Role of Helix 68 in the Elongation Step of Protein Biosynthesis

by Giuseppe Cimicata, Gil Fridkin, Tanaya Bose, Zohar Eyal, Yehuda Halfon, Elinor Breiner-Goldstein, Tara Fox, Ella Zimmerman, Anat Bashan, Natalia de Val, Alexander Wlodawer, Ada Yonath
Published 2022-04-01

Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

by Istvan Botos, George T. Lountos, Weimin Wu, Scott Cherry, Rodolfo Ghirlando, Arsen M. Kudzhaev, Tatyana V. Rotanova, Natalia de Val, Joseph E. Tropea, Alla Gustchina, Alexander Wlodawer
Published 2019-11-01

Unique Structural Fold of LonBA Protease from <i>Bacillus subtilis,</i> a Member of a Newly Identified Subfamily of Lon Proteases

by Alla Gustchina, Mi Li, Anna G. Andrianova, Arsen M. Kudzhaev, George T. Lountos, Bartosz Sekula, Scott Cherry, Joseph E. Tropea, Ivan V. Smirnov, Alexander Wlodawer, Tatyana V. Rotanova
Published 2022-09-01

Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysis.

by Elena Peletskaya, Mark Andrake, Alla Gustchina, George Merkel, Jerry Alexandratos, Dongwen Zhou, Ravi S Bojja, Tadashi Satoh, Mikhail Potapov, Alex Kogon, Viktor Potapov, Alexander Wlodawer, Anna Marie Skalka
Published 2011-01-01

Rapid response to emerging biomedical challenges and threats

by Marek Grabowski, Joanna M. Macnar, Marcin Cymborowski, David R. Cooper, Ivan G. Shabalin, Miroslaw Gilski, Dariusz Brzezinski, Marcin Kowiel, Zbigniew Dauter, Bernhard Rupp, Alexander Wlodawer, Mariusz Jaskolski, Wladek Minor
Published 2021-05-01