Nucleic acid-based vaccines targeting respiratory syncytial virus: Delivering the goods

by Trevor R. F. Smith, Katherine Schultheis, Kate E. Broderick
Published 2017-11-01

Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface Electroporation

by Kate E Broderick, Amy Chan, Feng Lin, Xuefei Shen, Gleb Kichaev, Amir S Khan, Justin Aubin, Tracy S Zimmermann, Niranjan Y. Sardesai
Published 2012-01-01

Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ

by Kaustuv Banerjee, Julie Hickman, Andrew Geall, Jeffrey B. Ulmer, Gleb Kichaev, Niranjan Y. Sardesai, Yen Cu, Susan Barnett, Gillis Otten, Kate E. Broderick
Published 2013-08-01

Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques

by Jingjing Jiang, Preeti Banglore, Kathleen A. Cashman, Connie S. Schmaljohn, Katherine Schultheis, Holly Pugh, Jacklyn Nguyen, Laurent M. Humeau, Kate E. Broderick, Stephanie J. Ramos
Published 2019-09-01

Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene Delivery Enhanced by Surface Dermal Electroporation

by Kate E. Broderick, Niranjan Y. Sardesai, Trevor R. F. Smith, William B. Kiosses, Christine L. Knott, Gleb Kichaev, Dinah H. Amante, Janess M. Mendoza
Published 2013-08-01

DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa and Ebola viruses in guinea pigs

by Kathleen A. Cashman, Eric R. Wilkinson, Suzanne E. Wollen, Joshua D. Shamblin, Justine M. Zelko, Jeremy J. Bearss, Xiankun Zeng, Kate E. Broderick, Connie S. Schmaljohn
Published 2017-12-01

Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaqu...

by Xintao Hu, Zhongyan Lu, Antonio Valentin, Margherita Rosati, Kate E. Broderick, Niranjan Y. Sardesai, Preston A. Marx, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Published 2018-09-01

DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response

by Trevor RF Smith, Katherine Schultheis, William B Kiosses, Dinah H Amante, Janess M Mendoza, John C Stone, Jay R McCoy, Niranjan Y Sardesai, Kate E Broderick
Published 2014-01-01

Adjuvant Screen Identifies Synthetic DNA-Encoding Flt3L and CD80 Immunotherapeutics as Candidates for Enhancing Anti-tumor T Cell Responses

by Amy Haseley Thorne, Kirsten N. Malo, Ashley J. Wong, Tricia T. Nguyen, Neil Cooch, Charles Reed, Jian Yan, Kate E. Broderick, Trevor R. F. Smith, Emma L. Masteller, Laurent Humeau
Published 2020-02-01

Immunotherapy with DNA vaccine and live attenuated rubella/SIV gag vectors plus early ART can prevent SIVmac251 viral rebound in acutely infected rhesus macaques.

by Konstantin Virnik, Margherita Rosati, Alexei Medvedev, Aaron Scanlan, Gabrielle Walsh, Frances Dayton, Kate E Broderick, Mark Lewis, Yvonne Bryson, Jeffrey D Lifson, Ruth M Ruprecht, Barbara K Felber, Ira Berkower
Published 2020-01-01

A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever

by Kathleen A. Cashman, Eric R. Wilkinson, Carl I. Shaia, Paul R. Facemire, Todd M. Bell, Jeremy J. Bearss, Joshua D. Shamblin, Suzanne E. Wollen, Kate E. Broderick, Niranjan Y. Sardesai, Connie S. Schmaljohn
Published 2017-12-01

Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal Electroporation

by Niranjan Y. Sardesai, Connie S. Schmaljohn, Catherine V. Badger, Mary C. Guttieri, Kristin W. Spik, Carl I. Shaia, Amy C. Shurtleff, Todd M. Bell, Kate E. Broderick, Eric R. Wilkinson, Kathleen A. Cashman
Published 2013-07-01

HIV Env conserved element DNA vaccine alters immunodominance in macaques

by Xintao Hu, Antonio Valentin, Margherita Rosati, Siriphan Manocheewa, Candido Alicea, Bhabadeb Chowdhury, Jenifer Bear, Kate E. Broderick, Niranjan Y. Sardesai, Sylvie Le Gall, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Published 2017-12-01

Live Virus Neutralisation of the 501Y.V1 and 501Y.V2 SARS-CoV-2 Variants following INO-4800 Vaccination of Ferrets

by Shane Riddell, Sarah Goldie, Alexander J. McAuley, Michael J. Kuiper, Peter A. Durr, Kim R. Blasdell, Mary Tachedjian, Julian D. Druce, Trevor R. F. Smith, Kate E. Broderick, Seshadri S. Vasan, Seshadri S. Vasan
Published 2021-06-01

HIV-1 Env DNA vaccine plus protein boost delivered by EP expands B- and T-cell responses and neutralizing phenotype in vivo.

by Kar Muthumani, Megan C Wise, Kate E Broderick, Natalie Hutnick, Jonathan Goodman, Seleeke Flingai, Jian Yan, Chaoran B Bian, Janess Mendoza, Colleen Tingey, Christine Wilson, Krzysztof Wojtak, Niranjan Y Sardesai, David B Weiner
Published 2013-01-01

Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity

by Katherine Schultheis, Holly M Pugh, Janet Oh, Jacklyn Nguyen, Bryan Yung, Charles Reed, Neil Cooch, Jing Chen, Jian Yan, Kar Muthumani, Laurent M. Humeau, David B. Weiner, Kate E. Broderick, Trevor R. F. Smith
Published 2020-09-01

Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.

by Viraj Kulkarni, Antonio Valentin, Margherita Rosati, Candido Alicea, Ashish K Singh, Rashmi Jalah, Kate E Broderick, Niranjan Y Sardesai, Sylvie Le Gall, Beatriz Mothe, Christian Brander, Morgane Rolland, James I Mullins, George N Pavlakis, Barbara K Felber
Published 2014-01-01

Protection against Borreliella burgdorferi infection mediated by a synthetically engineered DNA vaccine

by Ghiabe H. Guibinga, Bikash Sahay, Heather Brown, Neil Cooch, Jing Chen, Jian Yan, Charles Reed, Meerambika Mishra, Bryan Yung, Holly Pugh, Katherine Schultheis, Rianne N. Esquivel, David B. Weiner, Laurent H. Humeau, Kate E. Broderick, Trevor R.F. Smith
Published 2020-09-01

Multivalent DNA Vaccines as a Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses

by Jingjing Jiang, Stephanie J. Ramos, Preeti Bangalore, Dustin Elwood, Kathleen A. Cashman, Sagar B. Kudchodkar, Katherine Schultheis, Holly Pugh, Jewell Walters, Jared Tur, Jian Yan, Ami Patel, Kar Muthumani, Connie S. Schmaljohn, David B. Weiner, Laurent M. Humeau, Kate E. Broderick
Published 2021-02-01

Synthetic nucleic acid antibody prophylaxis confers rapid and durable protective immunity against Zika virus challenge

by Hyeree Choi, Sagar B. Kudchodkar, Emma L. Reuschel, Kanika Asija, Piyush Borole, Sangya Agarwal, Lucas Van Gorder, Charles C. Reed, Gayathri Gulendran, Stephanie Ramos, Kate E. Broderick, J Joseph Kim, Kenneth E. Ugen, Gary Kobinger, Don L. Siegel, David B. Weiner, Kar Muthumani
Published 2020-04-01