Pluripotent Stem Cell Models of Human Heart Disease

by Moretti, A., Laugwitz, K.L., Dorn, T., Sinnecker, D., Mummery, C.
Published 2013

SUBTY PE-SPECIFIC PROMOTER-DRIVEN ACTION POTENTIAL IMAGING FOR PRECISE DISEASE MODELING AND DRUG TESTING IN HIPSC-DERIVED CARDIOMYOCYTES

by Chen, Z., Xian, W., Bellin, M., Dorn, T., Tian, Q., Mummery, C.L., Lipp, P., Moretti, A., Sinnecker, D., Laugwitz, K.L.
Published 2016

Isogenic Sets of Human Pluripotent Stem Cells as Model of LQT2 Syndrome

by Casini, S., Bellin, M., Davis, R.P., Aniello, C. d', Haas, J., Ward-van Oostwaard, D., Tertoolen, L.G.J., Laugwitz, K.L., Moretti, A., Mummery, C.L.
Published 2014

A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

by Sala, L., Yu, Z., Ward-van Oostwaard, D., Veldhoven, J.P.D. van, Moretti, A., Laugwitz, K.L., Mummery, C.L., IJzerman, A.P., Bellin, M.
Published 2016

A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

by Sala, L., Yu, Z.Y., Ward-van Oostwaard, D., Veldhoven, J.P.D. van, Moretti, A., Laugwitz, K.L., Mummery, C.L., IJzerman, A.P., Bellin, M.
Published 2016

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome

by Bellin, M., Casini, S., Davis, R.P., D'Aniello, C., Haas, J., Ward-van Oostwaard, D., Tertoolen, L.G.J., Jung, C.B., Elliott, D.A., Welling, A., Laugwitz, K.L., Moretti, A., Mummery, C.L.
Published 2013

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy

by Gramlich, M., Pane, L.S., Zhou, Q.F., Chen, Z.F., Murgia, M., Schotterl, S., Goedel, A., Metzger, K., Brade, T., Parrotta, E., Schaller, M., Gerull, B., Thierfelder, L., Aartsma-Rus, A., Labeit, S., Atherton, J.J., McGaughran, J., Harvey, R.P., Sinnecker, D., Mann, M., Laugwitz, K.L., Gawaz, M.P., Moretti, A.
Published 2015

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes

by Chen, Z.F., Xian, W.Y., Bellin, M., Dorn, T., Tian, Q.H., Goedel, A., Dreizehnter, L., Schneider, C.M., Oostwaard, D.V., Ng, J.K.M., Hinkel, R., Pane, L.S., Mummery, C.L., Lipp, P., Moretti, A., Laugwitz, K.L., Sinnecker, D.
Published 2017

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

by Webb, T.R., Erdmann, J., Stirrups, K.E., Stitziel, N.O., Masca, N.G.D., Jansen, H., Kanoni, S., Nelson, C.P., Ferrario, P.G., Konig, I.R., Eicher, J.D., Johnson, A.D., Hamby, S.E., Betsholtz, C., Ruusalepp, A., Franzen, O., Schadt, E.E., Bjorkegren, J.L.M., Weeke, P.E., Auer, P.L., Schick, U.M., Lu, Y.C., Zhang, H., Dube, M.P., Goel, A., Farrall, M., Peloso, G.M., Won, H.H., , R. do, Iperen, E. van, Kruppa, J., Mahajan, A., Scott, R.A., Willenborg, C., Braund, P.S., Capelleveen, J.C. van, Doney, A.S.F., Donnelly, L.A., Asselta, R., Merlini, P.A., Duga, S., Marziliano, N., Denny, J.C., Shaffer, C., El-Mokhtari, N.E., Franke, A., Heilmann, S., Hengstenberg, C., Hoffmann, P., Holmen, O.L., Hveem, K., Jansson, J.H., Jockel, K.H., Kessler, T., Kriebel, J., Laugwitz, K.L., Marouli, E., Martinelli, N., McCarthy, M.I., Zuydam, N.R. van, Meisinger, C., Esko, T., Mihailov, E., Escher, S.A., Alver, M., Moebus, S., Morris, A.D., Virtamo, J., Nikpay, M., Olivieri, O., Provost, S., AlQarawi, A., Robertson, N.R., Akinsansya, K.O., Reilly, D.F., Vogt, T.F., Yin, W., Asselbergs, F.W., Kooperberg, C., Jackson, R.D., Stahl, E., Muller-Nurasyid, M., Strauch, K., Varga, T.V., Waldenberger, M., Zeng, L.Y., Chowdhury, R., Salomaa, V., Ford, I., Jukema, J.W., Amouyel, P., Kontto, J., Nordestgaard, B.G., Ferrieres, J., Saleheen, D., Sattar, N., Surendran, P., Wagner, A., Young, R., Howson, J.M.M., Butterworth, A.S., Danesh, J., Ardissino, D., Bottinger, E.P., Erbel, R., Franks, P.W., Girelli, D., Hall, A.S., Hovingh, G.K., Kastrati, A., Lieb, W., Meitinger, T., Kraus, W.E., Shah, S.H., McPherson, R., Orho-Melander, M., Melander, O., Metspalu, A., Palmer, C.N.A., Peters, A., Rader, D.J., Reilly, M.P., Loos, R.J.F., Reiner, A.P., Roden, D.M., Tardif, J.C., Thompson, J.R., Wareham, N.J., Watkins, H., Willer, C.J., Samani, N.J., Schunkert, H., Deloukas, P., Kathiresan, S., Wellcome Trust Case Control, MORGAM Investigators, Myocardial Infarction Genetics
Published 2017

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

by Webb, TR, Erdmann, J, Stirrups, KE, Stitziel, NO, Masca, NGD, Jansen, H, Kanoni, S, Nelson, CP, Ferrario, PG, König, IR, Eicher, JD, Johnson, AD, Hamby, SE, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, EE, Björkegren, JLM, Weeke, PE, Auer, PL, Schick, UM, Lu, Y, Zhang, H, Dube, M-P, Goel, A, Farrall, M, Peloso, GM, Won, H-H, Do, R, van Iperen, E, Kruppa, J, Mahajan, A, Scott, RA, Willenborg, C, Braund, PS, van Capelleveen, JC, Doney, ASF, Donnelly, LA, Asselta, R, Merlini, PA, Duga, S, Marziliano, N, Denny, JC, Shaffer, C, El-Mokhtari, NE, Franke, A, Heilmann, S, Hengstenberg, C, Hoffmann, P, Holmen, OL, Hveem, K, Jansson, J-H, Jöckel, K-H, Kessler, T, Kriebel, J, Laugwitz, KL, Marouli, E, Martinelli, N, McCarthy, MI, Van Zuydam, NR, Meisinger, C, Esko, T, Mihailov, E, Escher, SA, Alver, M, Moebus, S, Morris, AD, Virtamo, J, Nikpay, M, Olivieri, O, Provost, S, AlQarawi, A, Robertson, NR, Akinsansya, KO, Reilly, DF, Vogt, TF, Yin, W, Asselbergs, FW, Kooperberg, C, Jackson, RD, Stahl, E, Müller-Nurasyid, M, Strauch, K, Varga, TV, Waldenberger, M, Wellcome Trust Case Control Consortium, Zeng, L, Chowdhury, R, Salomaa, V, Ford, I, Jukema, JW, Amouyel, P, Kontto, J, MORGAM Investigators, Nordestgaard, BG, Ferrières, J, Saleheen, D, Sattar, N, Surendran, P, Wagner, A, Young, R, Howson, JMM, Butterworth, AS, Danesh, J, Ardissino, D, Bottinger, EP, Erbel, R, Franks, PW, Girelli, D, Hall, AS, Hovingh, GK, Kastrati, A, Lieb, W, Meitinger, T, Kraus, WE, Shah, SH, McPherson, R, Orho-Melander, M, Melander, O, Metspalu, A, Palmer, CNA, Peters, A, Rader, DJ, Reilly, MP, Loos, RJF, Reiner, AP, Roden, DM, Tardif, J-C, Thompson, JR, Wareham, NJ, Watkins, H, Willer, CJ, Samani, NJ, Schunkert, H, Deloukas, P, Kathiresan, S, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators
Published 2017