Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol

by Tietjen I., Hovingh G.K., Singaraja R.R., Radomski C., Barhdadi A., McEwen J., Chan E., Mattice M., Legendre A., Franchini P.L., Dubé M.-P., Kastelein J.J.P., Hayden M.R.
Published 2018

Adrenal Function in Females with Low Plasma HDL-C Due to Mutations in ABCA1 and LCAT

by Bochem, A.E., Holleboom, A.G., Romijn, J.A., Hoekstra, M., Dallinga, G.M., Motazacker, M.M., Hovingh, G.K., Kuivenhoven, J.A., Stroes, E.S.G.
Published 2014

Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin

by Brunham, L.R., Lansberg, P.J., Zhang, L., Miao, F., Carter, C., Hovingh, G.K., Visscher, H., Jukema, J.W., Stalenhoef, A.F., Ross, C.J.D., Carleton, B.C., Kastelein, J.J.P., Hayden, M.R.
Published 2012

High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C

by Bochem, A.E., Holleboom, A.G., Romijn, J.A., Hoekstra, M., Dallinga-Thie, G.M., Motazacker, M.M., Hovingh, G.K., Kuivenhoven, J.A., Stroes, E.S.G.
Published 2013

Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial

by Hovingh, G.K., Kastelein, J.J.P., Deventer, S.J.H. van, Round, P., Ford, J., Saleheen, D., Rader, D.J., Brewer, H.B., Barter, P.J.
Published 2015

New prospects for PCSK9 inhibition?

by Landmesser, U., Chapman, M.J., Stock, J.K., Amarenco, P., Belch, J.J.F., Boren, J., Farnier, M., Ference, B.A., Gielen, S., Graham, I., Grobbee, D.E., Hovingh, G.K., Luscher, T.F., Piepoli, M.F., Ray, K.K., Stroes, E.S., Wiklund, O., Windecker, S., Zamorano, J.L., Pinto, F., Tokgozoglu, L., Bax, J.J., Catapano, A.L., European Soc Cardiology, European Atherosclerosis Soc Task
Published 2018

Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

by Lim E.T., Würtz P., Havulinna A.S., Palta P., Tukiainen T., Rehnström K., Esko T., Mägi R., Inouye M., Lappalainen T., Chan Y., Salem R.M., Lek M., Flannick J., Sim X., Manning A., Ladenvall C., Bumpstead S., Hämäläinen E., Aalto K., Maksimow M., Salmi M., Blankenberg S., Ardissino D., Shah S., Horne B., McPherson R., Hovingh G.K., Reilly M.P., Watkins H., Goel A., Farrall M., Girelli D., Reiner A.P., Stitziel N.O., Kathiresan S., Gabriel S., Barrett J.C., Lehtimäki T., Laakso M., Groop L., Kaprio J., Perola M., McCarthy M.I., Boehnke M., Altshuler D.M., Lindgren C.M., Hirschhorn J.N., Metspalu A., Freimer N.B., Zeller T., Jalkanen S., Koskinen S., Raitakari O., Durbin R., MacArthur D.G., Salomaa V., Ripatti S., Daly M.J., Palotie A.
Published 2018

Heterozygosity for a Loss-of-Function Mutation in GALNT2 Improves Plasma Triglyceride Clearance in Man

by Holleboom, A.G., Karlsson, H., Lin, R.S., Beres, T.M., Sierts, J.A., Herman, D.S., Stroes, E.S.G., Aerts, J.M.F.G., Kastelein, J.J.P., Motazacker, M.M., Dallinga-Thie, G.M., Levels, J.H.M., Zwinderman, A.H., Seidman, J.G., Seidman, C.E., Ljunggren, S., Lefeber, D.J., Morava, E., Wevers, R.A., Fritz, T.A., Tabak, L.A., Lindahl, M., Hovingh, G.K., Kuivenhoven, J.A.
Published 2011

Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses

by Capelleveen, J.C. van, Kastelein, J.J.P., Zwinderman, A.H., Deventer, S.J.H. van, Collins, H.L., Adelman, S.J., Round, P., Ford, J., Rader, D.J., Hovingh, G.K.
Published 2016

High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins

by Hommes, J.W., Kratofil, R.M., Wahlen, S., Haas, C.J.C. de, Hildebrand, R.B., Hovingh, G.K., Otto, M., Eck, M. van, Hoekstra, M., Korporaal, S.J.A., Surewaard, B.G.J.
Published 2021

Neuroimmune guidance cues in vascular (patho)physiology

by Vreeken, D.
Published 2022

EPH receptor B2 stimulates human monocyte adhesion and migration independently of its EphrinB ligands

by Vreeken, D., Bruikman, C.S., Cox, S.M.L., Zhang, H.Y., Lalai, R., Koudijs, A., Zonneveld, A.J. van, Hovingh, G.K., Gils, J.M. van
Published 2020

Downregulation of endothelial plexin A4 under inflammatory conditions impairs vascular integrity

by Vreeken, D., Bruikman, C.S., Stam, W., Cox, S.M.L., Nagy, Z., Zhang, H.Y., Postma, R.J., Zonneveld, A.J. van, Hovingh, G.K., Gils, J.M. van
Published 2021

Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.

by Maiwald, S., Sivapalaratnam, S., Motazacker, M.M., Capelleveen, J.C. van, Bot, I., Jager, S.C. de, Eck, M. van, Jolley, J., Kuiper, J., Stephens, J., Albers, C.A., Vosmeer, C.R., Kruize, H., Geerke, D.P., Wal, A.C. van der, Loos, C.M. van der, Kastelein, J.J., Trip, M.D., Ouwehand, W.H., Dallinga-Thie, G.M., Hovingh, G.K.
Published 2014

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

by Postmus, I., Warren, H.R., Trompet, S., Arsenault, B.J., Avery, C.L., Bis, J.C., Chasman, D.I., Keyser, C.E. de, Deshmukh, H.A., Evans, D.S., Feng, Q.P., Li, X.H., Smit, R.A.J., Smith, A.V., Sun, F.G., Taylor, K.D., Arnold, A.M., Barnes, M.R., Barratt, B.J., Betteridge, J., Boekholdt, S.M., Boerwinkle, E., Buckley, B.M., Chen, Y.D.I., Craen, A.J.M. de, Cummings, S.R., Denny, J.C., Dube, M.P., Durrington, P.N., Eiriksdottir, G., Ford, I., Guo, X.Q., Harris, T.B., Heckbert, S.R., Hofman, A., Hovingh, G.K., Kastelein, J.J.P., Launer, L.J., Liu, C.T., Liu, Y.M., Lumley, T., McKeigue, P.M., Munroe, P.B., Neil, A., Nickerson, D.A., Nyberg, F., O'Brien, E., O'Donnell, C.J., Post, W., Poulter, N., Vasan, R.S., Rice, K., Rich, S.S., Rivadeneira, F., Sattar, N., Sever, P., Shaw-Hawkins, S., Shields, D.C., Slagboom, P.E., Smith, N.L., Smith, J.D., Sotoodehnia, N., Stanton, A., Stott, D.J., Stricker, B.H., Sturmer, T., Uitterlinden, A.G., Wei, W.Q., Westendorp, R.G.J., Whitsel, E.A., Wiggins, K.L., Wilke, R.A., Ballantyne, C.M., Colhoun, H.M., Cupples, L.A., Franco, O.H., Gudnason, V., Hitman, G., Palmer, C.N.A., Psaty, B.M., Ridker, P.M., Stafford, J.M., Stein, C.M., Tardif, J.C., Caulfield, M.J., Jukema, J.W., Rotter, J.I., Krauss, R.M.
Published 2016

The identification and function of a Netrin-1 mutation in a pedigree with premature atherosclerosis

by Bruikman, C.S., Vreeken, D., Zhang, H.Y., Gils, M.J. van, Peter, J., Zonneveld, A.J. van, Hovingh, G.K., Gils, J.M. van
Published 2020

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

by Postmus, I., Trompet, S., Deshmukh, H.A., Barnes, M.R., Li, X.H., Warren, H.R., Chasman, D.I., Zhou, K.X., Arsenault, B.J., Donnelly, L.A., Wiggins, K.L., Avery, C.L., Griffin, P., Feng, Q.P., Taylor, K.D., Li, G., Evans, D.S., Smith, A.V., Keyser, C.E. de, Johnson, A.D., Craen, A.J.M. de, Stott, D.J., Buckley, B.M., Ford, I., Westendorp, R.G.J., Slagboom, P.E., Sattar, N., Munroe, P.B., Sever, P., Poulter, N., Stanton, A., Shields, D.C., O'Brien, E., Shaw-Hawkins, S., Chen, Y.D.I., Nickerson, D.A., Smith, J.D., Dube, M.P., Boekholdt, S.M., Hovingh, G.K., Kastelein, J.J.P., McKeigue, P.M., Betteridge, J., Neil, A., Durrington, P.N., Doney, A., Carr, F., Morris, A., McCarthy, M.I., Groop, L., Ahlqvist, E., Bis, J.C., Rice, K., Smith, N.L., Lumley, T., Whitsel, E.A., Sturmer, T., Boerwinkle, E., Ngwa, J.S., O'Donnell, C.J., Vasan, R.S., Wei, W.Q., Wilke, R.A., Liu, C.T., Sun, F.G., Guo, X.Q., Heckbert, S.R., Post, W., Sotoodehnia, N., Arnold, A.M., Stafford, J.M., Ding, J.Z., Herrington, D.M., Kritchevsky, S.B., Eiriksdottir, G., Launer, L.J., Harris, T.B., Chu, A.Y., Giulianini, F., MacFadyen, J.G., Barratt, B.J., Nyberg, F., Stricker, B.H., Uitterlinden, A.G., Hofman, A., Rivadeneira, F., Emilsson, V., Franco, O.H., Ridker, P.M., Gudnason, V., Liu, Y.M., Denny, J.C., Ballantyne, C.M., Rotter, J.I., Cupples, L.A., Psaty, B.M., Palmer, C.N.A., Tardif, J.C., Colhoun, H.M., Hitman, G., Krauss, R.M., Jukema, J.W., Caulfield, M.J., Welcome Trust Case Control Consort
Published 2014

Netrin-1 and the Grade of Atherosclerosis Are Inversely Correlated in Humans

by Bruikman, C.S., Vreeken, D., Hoogeveen, R.M., Bom, M.J., Danad, I., Pinto-Sietsma, S.J., Zonneveld, A.J. van, Knaapen, P., Hovingh, G.K., Stroes, E.S.G., Gils, J.M. van
Published 2020

Secretory Phospholipase A(2)-IIA and Cardiovascular Disease

by Holmes, M.V., Simon, T., Exeter, H.J., Folkersen, L., Asselbergs, F.W., Guardiola, M., Cooper, J.A., Palmen, J., Hubacek, J.A., Carruthers, K.F., Horne, B.D., Brunisholz, K.D., Mega, J.L., Iperen, E.P.A. van, Li, M.Y., Leusink, M., Trompet, S., Verschuren, J.J.W., Hovingh, G.K., Dehghan, A., Nelson, C.P., Kotti, S., Danchin, N., Scholz, M., Haase, C.L., Rothenbacher, D., Swerdlow, D.I., Kuchenbaecker, K.B., Staines-Urias, E., Goel, A., Hooft, F. van 't, Gertow, K., Faire, U. de, Panayiotou, A.G., Tremoli, E., Baldassarre, D., Veglia, F., Holdt, L.M., Beutner, F., Gansevoort, R.T., Navis, G.J., Leach, I.M., Breitling, L.P., Brenner, H., Thiery, J., Dallmeier, D., Franco-Cereceda, A., Boer, J.M.A., Stephens, J.W., Hofker, M.H., Tedgui, A., Hofman, A., Uitterlinden, A.G., Adamkova, V., Pitha, J., Onland-Moret, N.C., Cramer, M.J., Nathoe, H.M., Spiering, W., Klungel, O.H., Kumari, M., Whincup, P.H., Morrow, D.A., Braund, P.S., Hall, A.S., Olsson, A.G., Doevendans, P.A., Trip, M.D., Tobin, M.D., Hamsten, A., Watkins, H., Koenig, W., Nicolaides, A.N., Teupser, D., Day, I.N.M., Carlquist, J.F., Gaunt, T.R., Ford, I., Sattar, N., Tsimikas, S., Schwartz, G.G., Lawlor, D.A., Morris, R.W., Sandhu, M.S., Poledne, R., Maitland-van der Zee, A.H., Khaw, K.T., Keating, B.J., Harst, P. van der, Price, J.F., Mehta, S.R., Yusuf, S., Witteman, J.C.M., Franco, O.H., Jukema, J.W., Knijff, P. de, Tybjaerg-Hansen, A., Rader, D.J., Farrall, M., Samani, N.J., Kivimaki, M., Fox, K.A.A., Humphries, S.E., Anderson, J.L., Boekholdt, S.M., Palmer, T.M., Eriksson, P., Pare, G., Hingorani, A.D., Sabatine, M.S., Mallat, Z., Casas, J.P., Talmud, P.J.
Published 2013

Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report

by Verbeek, R, Boyer, M, Boekholdt, SM, Hovingh, GK, Kastelein, JJP, Wareham, N, Khaw, K-T, Arsenault, BJ
Published 2017