Unveiling the culprit: the fusobacterium lineage that populates colorectal cancer

by Johannes Betge, Matthias P. Ebert
Published 2024-05-01

Precision medicine for metastatic colorectal cancer in clinical practice

by Julian E. Riedesser, Matthias P. Ebert, Johannes Betge
Published 2022-01-01

Prognostic Cancer Gene Expression Signatures: Current Status and Challenges

by Yuquan Qian, Jimmy Daza, Timo Itzel, Johannes Betge, Tianzuo Zhan, Frederik Marmé, Andreas Teufel
Published 2021-03-01

A multicenter open-label phase II trial to evaluate nivolumab and ipilimumab for 2nd line therapy in elderly patients with advanced esophageal squamous cell cancer (RAMONA)

by Nadja M. Meindl-Beinker, Johannes Betge, Tobias Gutting, Elke Burgermeister, Sebastian Belle, Tianzuo Zhan, Nadine Schulte, Martin Maenz, Matthias P. Ebert, Nicolai Haertel
Published 2019-03-01

A multicenter phase 4 geriatric assessment directed trial to evaluate gemcitabine +/− nab-paclitaxel in elderly pancreatic cancer patients (GrantPax)

by Johannes Betge, Jing Chi-Kern, Nadine Schulte, Sebastian Belle, Tobias Gutting, Elke Burgermeister, Ralf Jesenofsky, Martin Maenz, Ulrich Wedding, Matthias P. Ebert, Nicolai Haertel
Published 2018-07-01

Clinical impact of panel gene sequencing on therapy of advanced cancers of the digestive system: a retrospective, single center study

by Lena Dreikhausen, Anna Klupsch, Isabella Wiest, Qiyun Xiao, Nadine Schulte, Johannes Betge, Tobias Boch, Christoph Brochhausen, Timo Gaiser, Ralf-Dieter Hofheinz, Matthias Ebert, Tianzuo Zhan
Published 2024-04-01

Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

by Johannes Betge, Grainne Kerr, Thilo Miersch, Svenja Leible, Gerrit Erdmann, Christian L Galata, Tianzuo Zhan, Timo Gaiser, Stefan Post, Matthias P Ebert, Karoline Horisberger, Michael Boutros
Published 2015-01-01

Detection of mutational patterns in cell‐free DNA of colorectal cancer by custom amplicon sequencing

by Simon Herrmann, Tianzuo Zhan, Johannes Betge, Benedikt Rauscher, Sebastian Belle, Tobias Gutting, Nadine Schulte, Ralf Jesenofsky, Nicolai Härtel, Timo Gaiser, Ralf‐Dieter Hofheinz, Matthias P. Ebert, Michael Boutros
Published 2019-08-01

Patient-Derived Organoids of Cholangiocarcinoma

by Christopher Fabian Maier, Lei Zhu, Lahiri Kanth Nanduri, Daniel Kühn, Susan Kochall, May-Linn Thepkaysone, Doreen William, Konrad Grützmann, Barbara Klink, Johannes Betge, Jürgen Weitz, Nuh N. Rahbari, Christoph Reißfelder, Sebastian Schölch
Published 2021-08-01

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

by Tianzuo Zhan, Giulia Ambrosi, Anna Maxi Wandmacher, Benedikt Rauscher, Johannes Betge, Niklas Rindtorff, Ragna S. Häussler, Isabel Hinsenkamp, Leonhard Bamberg, Bernd Hessling, Karin Müller-Decker, Gerrit Erdmann, Elke Burgermeister, Matthias P. Ebert, Michael Boutros
Published 2019-05-01

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth facto...

by Elke Burgermeister, Francesca Battaglin, Fagr Eladly, Wen Wu, Frank Herweck, Nadine Schulte, Johannes Betge, Nicolai Härtel, Jakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert
Published 2019-07-01

PPARγ induces PD-L1 expression in MSS+ colorectal cancer cells

by Tobias Gutting, Veronika Hauber, Jens Pahl, Kay Klapproth, Wenyue Wu, Ioana Dobrota, Frank Herweck, Juliane Reichling, Laura Helm, Torsten Schroeder, Beifang Li, Philip Weidner, Tianzuo Zhan, Maximilian Eckardt, Johannes Betge, Sebastian Belle, Carsten Sticht, Timo Gaiser, Michael Boutros, Matthias P.A. Ebert, Adelheid Cerwenka, Elke Burgermeister
Published 2021-01-01

The drug-induced phenotypic landscape of colorectal cancer organoids

by Johannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini, Kim E. Boonekamp, Veronika Hauber, Tobias Gutting, Larissa Frank, Sebastian Belle, Timo Gaiser, Inga Buchholz, Ralf Jesenofsky, Nicolai Härtel, Tianzuo Zhan, Bernd Fischer, Katja Breitkopf-Heinlein, Elke Burgermeister, Matthias P. Ebert, Michael Boutros
Published 2022-06-01

Analysis of cell free DNA to predict outcome to bevacizumab therapy in colorectal cancer patients

by Tom Venken, Ian S. Miller, Ingrid Arijs, Valentina Thomas, Ana Barat, Johannes Betge, Tianzuo Zhan, Timo Gaiser, Matthias P. Ebert, Alice C. O’Farrell, Jochen Prehn, Rut Klinger, Darran P. O’Connor, Brian Moulton, Verena Murphy, Garazi Serna, Paolo G. Nuciforo, Ray McDermott, Brian Bird, Gregory Leonard, Liam Grogan, Anne Horgan, Nadine Schulte, Markus Moehler, Diether Lambrechts, Annette T. Byrne
Published 2024-05-01

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

by Dominiek Smeets, Ian S. Miller, Darran P. O’Connor, Sudipto Das, Bruce Moran, Bram Boeckx, Timo Gaiser, Johannes Betge, Ana Barat, Rut Klinger, Nicole C. T. van Grieken, Chiara Cremolini, Hans Prenen, Massimiliano Mazzone, Jeroen Depreeuw, Orna Bacon, Bozena Fender, Joseph Brady, Bryan T. Hennessy, Deborah A. McNamara, Elaine Kay, Henk M. Verheul, Neerincx Maarten, William M. Gallagher, Verena Murphy, Jochen H. M. Prehn, Miriam Koopman, Cornelis J. A. Punt, Fotios Loupakis, Matthias P. A. Ebert, Bauke Ylstra, Diether Lambrechts, Annette T. Byrne
Published 2018-10-01

Second-line therapy with nivolumab plus ipilimumab for older patients with oesophageal squamous cell cancer (RAMONA): a multicentre, open-label phase 2 trial

by Matthias P Ebert, ProfMD, Nadja M Meindl-Beinker, PhD, Tobias Gutting, MD, Martin Maenz, PhD, Johannes Betge, MD, Nadine Schulte, MD, Tianzuo Zhan, MD, Philip Weidner, MD, Elke Burgermeister, PhD, Ralf Hofheinz, ProfMD, Arndt Vogel, ProfMD, Stefan Angermeier, MD, Claus Bolling, MD, Maike de Wit, ProfMD, Ralf Jakobs, ProfMD, Meinolf Karthaus, ProfMD, Gertraud Stocker, MD, Peter Thuss-Patience, MD, Tobias Leidig, PhD, Timo Gaiser, ProfMD, Jakob N Kather, ProfMD, Nicolai Haertel, MD
Published 2022-06-01