Patterns of Tumor Progression Predict Small and Tissue-Specific Tumor-Originating Niches

by Thomas Buder, Thomas Buder, Andreas Deutsch, Barbara Klink, Barbara Klink, Barbara Klink, Barbara Klink, Anja Voss-Böhme, Anja Voss-Böhme
Published 2019-01-01

Network-based analysis of oligodendrogliomas predicts novel cancer gene candidates within the region of the 1p/19q co-deletion

by Josef Gladitz, Barbara Klink, Michael Seifert
Published 2018-06-01

Comparative analysis of histologically classified oligodendrogliomas reveals characteristic molecular differences between subgroups

by Chris Lauber, Barbara Klink, Michael Seifert
Published 2018-04-01

A mathematical model of the metastatic bottleneck predicts patient outcome and response to cancer treatment.

by Ewa Szczurek, Tyll Krüger, Barbara Klink, Niko Beerenwinkel
Published 2020-10-01

Model-Based Evaluation of Spontaneous Tumor Regression in Pilocytic Astrocytoma.

by Thomas Buder, Andreas Deutsch, Barbara Klink, Anja Voss-Böhme
Published 2015-12-01

Cell adhesion heterogeneity reinforces tumour cell dissemination: novel insights from a mathematical model

by David Reher, Barbara Klink, Andreas Deutsch, Anja Voss-Böhme
Published 2017-08-01

Network-based analysis of prostate cancer cell lines reveals novel marker gene candidates associated with radioresistance and patient relapse.

by Michael Seifert, Claudia Peitzsch, Ielizaveta Gorodetska, Caroline Börner, Barbara Klink, Anna Dubrovska
Published 2019-11-01

Molecular Characterization of Astrocytoma Progression Towards Secondary Glioblastomas Utilizing Patient-Matched Tumor Pairs

by Michael Seifert, Gabriele Schackert, Achim Temme, Evelin Schröck, Andreas Deutsch, Barbara Klink
Published 2020-06-01

Autoregressive higher-order hidden Markov models: exploiting local chromosomal dependencies in the analysis of tumor expression profiles.

by Michael Seifert, Khalil Abou-El-Ardat, Betty Friedrich, Barbara Klink, Andreas Deutsch
Published 2014-01-01

Glioblastomas with Oligodendroglial Component – Common Origin of the Different Histological Parts and Genetic Subclassification

by Barbara Klink, Ben Schlingelhof, Martin Klink, Karen Stout-Weider, Stephan Patt, Evelin Schrock
Published 2010-01-01

Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells

by Marina Conde, Susanne Michen, Ralf Wiedemuth, Barbara Klink, Evelin Schröck, Gabriele Schackert, Achim Temme
Published 2017-12-01

Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model

by Maximilian Clausing, Doreen William, Matthias Preussler, Julia Biedermann, Konrad Grützmann, Susan Richter, Frank Buchholz, Achim Temme, Evelin Schröck, Barbara Klink
Published 2022-05-01

Targeted Quantification of Carbon Metabolites Identifies Metabolic Progression Markers and an Undiagnosed Case of SDH-Deficient Clear Cell Renal Cell Carcinoma in a German Cohort

by Doreen William, Kati Erdmann, Jonas Ottemöller, Anastasios Mangelis, Catleen Conrad, Mirko Peitzsch, Evelin Schröck, Graeme Eisenhofer, Aristeidis Zacharis, Susanne Füssel, Daniela Aust, Barbara Klink, Susan Richter
Published 2021-11-01

Patient-Derived Organoids of Cholangiocarcinoma

by Christopher Fabian Maier, Lei Zhu, Lahiri Kanth Nanduri, Daniel Kühn, Susan Kochall, May-Linn Thepkaysone, Doreen William, Konrad Grützmann, Barbara Klink, Johannes Betge, Jürgen Weitz, Nuh N. Rahbari, Christoph Reißfelder, Sebastian Schölch
Published 2021-08-01

Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids

by Max Naumann, Tabea Czempiel, Anna Jana Lößner, Kristin Pape, Elke Beyreuther, Steffen Löck, Stephan Drukewitz, Alexander Hennig, Cläre von Neubeck, Barbara Klink, Mechthild Krause, Doreen William, Daniel E. Stange, Rebecca Bütof, Antje Dietrich
Published 2022-08-01

Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.

by Lara Marrone, Christine Bus, David Schöndorf, Julia Catherine Fitzgerald, Manuela Kübler, Benjamin Schmid, Peter Reinhardt, Lydia Reinhardt, Michela Deleidi, Tanya Levin, Andrea Meixner, Barbara Klink, Michael Glatza, Christian Johannes Gloeckner, Thomas Gasser, Jared Sterneckert
Published 2018-01-01

Targeted capture-based NGS is superior to multiplex PCR-based NGS for hereditary BRCA1 and BRCA2 gene analysis in FFPE tumor samples

by Falk Zakrzewski, Laura Gieldon, Andreas Rump, Michael Seifert, Konrad Grützmann, Alexander Krüger, Sina Loos, Silke Zeugner, Karl Hackmann, Joseph Porrmann, Johannes Wagner, Karin Kast, Pauline Wimberger, Gustavo Baretton, Evelin Schröck, Daniela Aust, Barbara Klink
Published 2019-04-01

Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing.

by Sophie Eisenreich, Khalil Abou-El-Ardat, Karol Szafranski, Jaime A Campos Valenzuela, Andreas Rump, Janice M Nigro, Rolf Bjerkvig, Eva-Maria Gerlach, Karl Hackmann, Evelin Schröck, Dietmar Krex, Lars Kaderali, Gabriele Schackert, Matthias Platzer, Barbara Klink
Published 2013-01-01

Differential Effects of Trp53 Alterations in Murine Colorectal Cancer

by Alexander M. Betzler, Lahiri K. Nanduri, Barbara Hissa, Linda Blickensdörfer, Michael H. Muders, Janine Roy, Moritz Jesinghaus, Katja Steiger, Wilko Weichert, Matthias Kloor, Barbara Klink, Michael Schroeder, Massimiliano Mazzone, Jürgen Weitz, Christoph Reissfelder, Nuh N. Rahbari, Sebastian Schölch
Published 2021-02-01

The dopamine receptor D1 inhibitor, SKF83566, suppresses GBM stemness and invasion through the DRD1-c-Myc-UHRF1 interactions

by Zhiyi Xue, Yan Zhang, Ruiqi Zhao, Xiaofei Liu, Konrad Grützmann, Barbara Klink, Xun Zhang, Shuai Wang, Wenbo Zhao, Yanfei Sun, Mingzhi Han, Xu Wang, Yaotian Hu, Xuemeng Liu, Ning Yang, Chen Qiu, Wenjie Li, Bin Huang, Xingang Li, Rolf Bjerkvig, Jian Wang, Wenjing Zhou
Published 2024-01-01