Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme

by Joe A. Kaczmarski, Mithun C. Mahawaththa, Akiva Feintuch, Ben E. Clifton, Luke A. Adams, Daniella Goldfarb, Gottfried Otting, Colin J. Jackson
Published 2020-11-01

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

by Deepyan Chatterjee, Fiona J. Lewis, Henry J. Sutton, Joe A. Kaczmarski, Xin Gao, Yeping Cai, Hayley A. McNamara, Colin J. Jackson, Ian A. Cockburn
Published 2021-04-01

Exploring the selectivity and engineering potential of an NRPS condensation domain involved in the biosynthesis of the thermophilic siderophore fuscachelin

by Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Thierry Izoré, Thierry Izoré, Joe A. Kaczmarski, Joe A. Kaczmarski, Edward Marschall, Edward Marschall, Edward Marschall, Minuri S. Ratnayake, Minuri S. Ratnayake, Minuri S. Ratnayake, Julien Tailhades, Julien Tailhades, Julien Tailhades, David L. Steer, David L. Steer, Ralf B. Schittenhelm, Ralf B. Schittenhelm, Manuela Tosin, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Max J. Cryle, Max J. Cryle, Max J. Cryle
Published 2023-06-01

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

by Camilla R Fisher, Henry J Sutton, Joe A Kaczmarski, Hayley A McNamara, Ben Clifton, Joshua Mitchell, Yeping Cai, Johanna N Dups, Nicholas J D'Arcy, Mandeep Singh, Aaron Chuah, Thomas S Peat, Colin J Jackson, Ian A Cockburn
Published 2017-07-01

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

by Thierry Izoré, Y. T. Candace Ho, Joe A. Kaczmarski, Athina Gavriilidou, Ka Ho Chow, David L. Steer, Robert J. A. Goode, Ralf B. Schittenhelm, Julien Tailhades, Manuela Tosin, Gregory L. Challis, Elizabeth H. Krenske, Nadine Ziemert, Colin J. Jackson, Max J. Cryle
Published 2021-05-01

P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate

by Songya Zhang, Lin Zhang, Anja Greule, Julien Tailhades, Edward Marschall, Panward Prasongpholchai, Daniel J. Leng, Jingfan Zhang, Jing Zhu, Joe A. Kaczmarski, Ralf B. Schittenhelm, Oliver Einsle, Colin J. Jackson, Fabrizio Alberti, Andreas Bechthold, Youming Zhang, Manuela Tosin, Tong Si, Max J. Cryle
Published 2023-08-01

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

by Anja Greule, Thierry Izoré, Dumitrita Iftime, Julien Tailhades, Melanie Schoppet, Yongwei Zhao, Madeleine Peschke, Iftekhar Ahmed, Andreas Kulik, Martina Adamek, Robert J. A. Goode, Ralf B. Schittenhelm, Joe A. Kaczmarski, Colin J. Jackson, Nadine Ziemert, Elizabeth H. Krenske, James J. De Voss, Evi Stegmann, Max J. Cryle
Published 2019-06-01