Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

by Miriam Kaltenbach, Colin J Jackson, Eleanor C Campbell, Florian Hollfelder, Nobuhiko Tokuriki
Published 2015-08-01

Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade

by Audrey A Burnim, Matthew A Spence, Da Xu, Colin J Jackson, Nozomi Ando
Published 2022-09-01

Classification and substrate head-group specificity of membrane fatty acid desaturases

by Dongdi Li, Ruth Moorman, Thomas Vanhercke, James Petrie, Surinder Singh, Colin J. Jackson
Published 2016-01-01

Geographic Linkage and Variation in Cryptosporidium hominis

by Rachel M. Chalmers, Stephen J. Hadfield, Colin J. Jackson, Kristin Elwin, Lihua Xiao, Paul Hunter
Published 2008-03-01

Exploring the selectivity and engineering potential of an NRPS condensation domain involved in the biosynthesis of the thermophilic siderophore fuscachelin

by Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Thierry Izoré, Thierry Izoré, Joe A. Kaczmarski, Joe A. Kaczmarski, Edward Marschall, Edward Marschall, Edward Marschall, Minuri S. Ratnayake, Minuri S. Ratnayake, Minuri S. Ratnayake, Julien Tailhades, Julien Tailhades, Julien Tailhades, David L. Steer, David L. Steer, Ralf B. Schittenhelm, Ralf B. Schittenhelm, Manuela Tosin, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Max J. Cryle, Max J. Cryle, Max J. Cryle
Published 2023-06-01

Improved production of the non-native cofactor F420 in Escherichia coli

by Mihir V. Shah, Hadi Nazem-Bokaee, James Antoney, Suk Woo Kang, Colin J. Jackson, Colin Scott
Published 2021-11-01

A 5000-fold increase in the specificity of a bacterial phosphotriesterase for malathion through combinatorial active site mutagenesis.

by Tatheer Naqvi, Andrew C Warden, Nigel French, Elena Sugrue, Paul D Carr, Colin J Jackson, Colin Scott
Published 2014-01-01

Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera.

by Sunita Biswas, Robyn J Russell, Colin J Jackson, Maria Vidovic, Olga Ganeshina, John G Oakeshott, Charles Claudianos
Published 2008-01-01

Intramolecular epistasis and the evolution of a new enzymatic function.

by Sajid Noor, Matthew C Taylor, Robyn J Russell, Lars S Jermiin, Colin J Jackson, John G Oakeshott, Colin Scott
Published 2012-01-01

Kinetic and sequence-structure-function analysis of known LinA variants with different hexachlorocyclohexane isomers.

by Pooja Sharma, Rinku Pandey, Kirti Kumari, Gunjan Pandey, Colin J Jackson, Robyn J Russell, John G Oakeshott, Rup Lal
Published 2011-01-01

Structural and functional characterization of a putative de novo gene in Drosophila

by Andreas Lange, Prajal H. Patel, Brennen Heames, Adam M. Damry, Thorsten Saenger, Colin J. Jackson, Geoffrey D. Findlay, Erich Bornberg-Bauer
Published 2021-03-01

Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme

by Joe A. Kaczmarski, Mithun C. Mahawaththa, Akiva Feintuch, Ben E. Clifton, Luke A. Adams, Daniella Goldfarb, Gottfried Otting, Colin J. Jackson
Published 2020-11-01

Correction to “Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases”

by Madhuri Gade, Li Lynn Tan, Adam M. Damry, Mahakaran Sandhu, Joseph S. Brock, Andie Delaney, Alejandro Villar-Briones, Colin J. Jackson, Paola Laurino
Published 2022-01-01

Cofactor F₄₂₀-Dependent Enzymes: An Under-Explored Resource for Asymmetric Redox Biocatalysis

by Mihir V. Shah, James Antoney, Suk Woo Kang, Andrew C. Warden, Carol J. Hartley, Hadi Nazem-Bokaee, Colin J. Jackson, Colin Scott
Published 2019-10-01

Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases

by Madhuri Gade, Li Lynn Tan, Adam M. Damry, Mahakaran Sandhu, Joseph S. Brock, Andie Delaney, Alejandro Villar-Briones, Colin J. Jackson, Paola Laurino
Published 2021-11-01

Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes

by Florian Baier, Nansook Hong, Gloria Yang, Anna Pabis, Charlotte M Miton, Alexandre Barrozo, Paul D Carr, Shina CL Kamerlin, Colin J Jackson, Nobuhiko Tokuriki
Published 2019-02-01

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

by Deepyan Chatterjee, Fiona J. Lewis, Henry J. Sutton, Joe A. Kaczmarski, Xin Gao, Yeping Cai, Hayley A. McNamara, Colin J. Jackson, Ian A. Cockburn
Published 2021-04-01

Local Efficacy of Glutamate Uptake Decreases with Synapse Size

by Michel K. Herde, Kirsten Bohmbach, Cátia Domingos, Natascha Vana, Joanna A. Komorowska-Müller, Stefan Passlick, Inna Schwarz, Colin J. Jackson, Dirk Dietrich, Martin K. Schwarz, Christian Henneberger
Published 2020-09-01

Cofactor Tail Length Modulates Catalysis of Bacterial F420-Dependent Oxidoreductases

by Blair Ney, Blair Ney, Carlo R. Carere, Richard Sparling, Richard Sparling, Thanavit Jirapanjawat, Matthew B. Stott, Colin J. Jackson, John G. Oakeshott, Andrew C. Warden, Chris Greening, Chris Greening
Published 2017-09-01

A revised biosynthetic pathway for the cofactor F420 in prokaryotes

by Ghader Bashiri, James Antoney, Ehab N. M. Jirgis, Mihir V. Shah, Blair Ney, Janine Copp, Stephanie M. Stuteley, Sreevalsan Sreebhavan, Brian Palmer, Martin Middleditch, Nobuhiko Tokuriki, Chris Greening, Colin Scott, Edward N. Baker, Colin J. Jackson
Published 2019-04-01