Adapt or Die: Targeting Unique Transmission-Stage Biology for Malaria Elimination

by Mariëtte E. van der Watt, Janette Reader, Janette Reader, Lyn-Marié Birkholtz, Lyn-Marié Birkholtz
Published 2022-06-01

Streamlined and Robust Stage-Specific Profiling of Gametocytocidal Compounds Against Plasmodium falciparum

by Janette Reader, Mariette E. van der Watt, Mariette E. van der Watt, Lyn-Marié Birkholtz
Published 2022-06-01

H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum

by Jessica Connacher, Gabrielle A. Josling, Lindsey M. Orchard, Janette Reader, Manuel Llinás, Lyn-Marié Birkholtz
Published 2021-04-01

The ecdysone receptor regulates several key physiological factors in Anopheles funestus

by Surina Maharaj, Elodie Ekoka, Erica Erlank, Luisa Nardini, Janette Reader, Lyn-Marie Birkholtz, Lizette L. Koekemoer
Published 2022-03-01

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation

by Riëtte van Biljon, Roelof van Wyk, Heather J. Painter, Lindsey Orchard, Janette Reader, Jandeli Niemand, Manuel Llinás, Lyn-Marie Birkholtz
Published 2019-12-01

The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage <i>P. falciparum</i> Parasites, DMPK Properties, and the Case for Artemiside

by Liezl Gibhard, Dina Coertzen, Janette Reader, Mariëtte E. van der Watt, Lyn-Marie Birkholtz, Ho Ning Wong, Kevin T. Batty, Richard K. Haynes, Lubbe Wiesner
Published 2021-12-01

Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products

by Phanankosi Moyo, William Shamburger, Mariëtte E. van der Watt, Janette Reader, Ana Carolina C. de Sousa, Timothy J. Egan, Vinesh J. Maharaj, Gerhard Bringmann, Lyn-Marie Birkholtz
Published 2020-08-01

Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C...

by Ho Ning Wong, Vivian Padín-Irizarry, Mariëtte E. van der Watt, Janette Reader, Wilna Liebenberg, Lubbe Wiesner, Peter Smith, Korina Eribez, Elizabeth A. Winzeler, Dennis E. Kyle, Lyn-Marie Birkholtz, Dina Coertzen, Richard K. Haynes
Published 2020-01-01

Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer

by Yabalu Z. Abacha, Yabalu Z. Abacha, Arnold Donkor Forkuo, Stephen Y. Gbedema, Nimisha Mittal, Sabine Ottilie, Frances Rocamora, Elizabeth A. Winzeler, Donelly A. van Schalkwyk, John M. Kelly, Martin C. Taylor, Janette Reader, Lyn-Marie Birkholtz, David R. Lisgarten, Jeremy K. Cockcroft, John N. Lisgarten, Rex A. Palmer, Rosemary C. Talbert, Steven D. Shnyder, Colin W. Wright
Published 2022-04-01

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

by Janette Reader, Mariëtte E. van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja Lauterbach, Belinda Bezuidenhout, Andre Horatscheck, Ashleigh van Heerden, Natalie J. Spillman, Anne N. Cowell, Jessica Connacher, Daniel Opperman, Lindsey M. Orchard, Manuel Llinás, Eva S. Istvan, Daniel E. Goldberg, Grant A. Boyle, David Calvo, Dalu Mancama, Theresa L. Coetzer, Elizabeth A. Winzeler, James Duffy, Lizette L. Koekemoer, Gregory Basarab, Kelly Chibale, Lyn-Marié Birkholtz
Published 2021-01-01