Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B

by Shinji Nakayama, Kota Toshimoto, Shinji Yamazaki, Jan Snoeys, Yuichi Sugiyama
Published 2023-10-01

Genome-wide association study of abnormal elevation of ALT in patients exposed to atabecestat

by Qingqin S. Li, Stephan Francke, Jan Snoeys, John Thipphawong, Gary Romano, Gerald P. Novak
Published 2023-09-01

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

by Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami‐Hodjegan, Aleksandra Galetin
Published 2021-05-01

Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

by Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Published 2023-01-01

Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition

by Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Published 2021-12-01

The relative atherogenicity of VLDL and LDL is dependent on the topographic site[S]

by Eline Van Craeyveld, Frank Jacobs, Yingmei Feng, Leen C.J. Thomassen, Johan A. Martens, Joke Lievens, Jan Snoeys, Bart De Geest
Published 2010-06-01

Prediction of the drug–drug interaction potential of the α1‐acid glycoprotein bound, CYP3A4/CYP2C9 metabolized oncology drug, erdafitinib

by Loeckie De Zwart, Jan Snoeys, Frank Jacobs, Lilian Y. Li, Italo Poggesi, Peter Verboven, Ivo Goris, Ellen Scheers, Inneke Wynant, Mario Monshouwer, Rao N. V. S. Mamidi
Published 2021-09-01

In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System

by Fanny Knöspel, Frank Jacobs, Nora Freyer, Georg Damm, An De Bondt, Ilse van den Wyngaert, Jan Snoeys, Mario Monshouwer, Marco Richter, Nadja Strahl, Daniel Seehofer, Katrin Zeilinger
Published 2016-04-01

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

by Ruben Boon, Manoj Kumar, Tine Tricot, Ilaria Elia, Laura Ordovas, Frank Jacobs, Jennifer One, Jonathan De Smedt, Guy Eelen, Matthew Bird, Philip Roelandt, Ginevra Doglioni, Kim Vriens, Matteo Rossi, Marta Aguirre Vazquez, Thomas Vanwelden, François Chesnais, Adil El Taghdouini, Mustapha Najimi, Etienne Sokal, David Cassiman, Jan Snoeys, Mario Monshouwer, Wei-Shou Hu, Christian Lange, Peter Carmeliet, Sarah-Maria Fendt, Catherine M. Verfaillie
Published 2020-03-01