Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

by Manoranjenni Chetty, Theresa Cain, Janak Wedagedera, Amin Rostami-Hodjegan, Amin Rostami-Hodjegan, Masoud Jamei
Published 2018-03-01

Opening a debate on open‐source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate

by Amin Rostami‐Hodjegan, Frederic Y. Bois
Published 2021-05-01

Editorial: Precision Medicine: Impact of Cytochromes P450 and Transporters Genetic Polymorphisms, Drug-Drug Interactions, Disease on Safety and Efficacy of Drugs

by Youssef Daali, Youssef Daali, Youssef Daali, Amin Rostami-Hodjegan, Amin Rostami-Hodjegan, Caroline F. Samer, Caroline F. Samer
Published 2022-01-01

Precision medicine technology hype or reality? The example of computer-guided dosing [version 1; peer review: 2 approved]

by Thomas M. Polasek, Sepehr Shakib, Amin Rostami-Hodjegan
Published 2019-10-01

Precision medicine technology reality not hype - The example of model-informed precision dosing [version 2; peer review: 2 approved]

by Thomas M. Polasek, Sepehr Shakib, Amin Rostami-Hodjegan
Published 2019-12-01

Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

by Hiroyuki Takita, Adam S. Darwich, Amais Ahmad, Amin Rostami‐Hodjegan
Published 2020-11-01

Seeing what is behind the smokescreen: A systematic review of methodological aspects of smoking interaction studies over the last three decades and implications for future clinical...

by Robert Hermann, Amin Rostami‐Hodjegan, Ping Zhao, Isabelle Ragueneau‐Majlessi
Published 2023-05-01

Precision dosing to avoid adverse drug reactions

by Thomas M. Polasek, Carl M. J. Kirkpatrick, Amin Rostami-Hodjegan
Published 2019-12-01

Proteomic quantification of receptor tyrosine kinases involved in the development and progression of colorectal cancer liver metastasis

by Areti-Maria Vasilogianni, Zubida M. Al-Majdoub, Brahim Achour, Brahim Achour, Sheila Annie Peters, Sheila Annie Peters, Amin Rostami-Hodjegan, Amin Rostami-Hodjegan, Jill Barber
Published 2023-02-01

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

by Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami‐Hodjegan, Aleksandra Galetin
Published 2021-05-01

Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn’s Disease Patients through PBPK Modeling

by Chunyan Han, Tiancheng Sun, Siri Kalyan Chirumamilla, Frederic Y. Bois, Mandy Xu, Amin Rostami-Hodjegan
Published 2023-08-01

A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations

by Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew‐Mei Huang, Amin Rostami‐Hodjegan, Aleksandra Galetin
Published 2020-06-01

Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions

by Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew‐Mei Huang, Amin Rostami‐Hodjegan, Aleksandra Galetin
Published 2020-05-01

Delineating gene–environment effects using virtual twins of patients treated with clozapine

by Sam Mostafa, Thomas M. Polasek, Chad Bousman, Amin Rostami‐Hodjegan, Leslie J. Sheffield, Ian Everall, Christos Pantelis, Carl M. J. Kirkpatrick
Published 2023-02-01

Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia

by Sam Mostafa, Reza Rafizadeh, Thomas M. Polasek, Chad A. Bousman, Amin Rostami‐Hodjegan, Robert Stowe, Prescilla Carrion, Leslie J. Sheffield, Carl M. J. Kirkpatrick
Published 2024-03-01