In silico modeling and simulation of organ‐on‐a‐chip systems to support data analysis and a priori experimental design

by Nicoló Milani, Neil Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
Published 2024-04-01

PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter‐Individual Variability

by Hiroyuki Takita, Shelby Barnett, Yueping Zhang, Karelle Ménochet, Hong Shen, Kayode Ogungbenro, Aleksandra Galetin
Published 2021-02-01

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

by Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami‐Hodjegan, Aleksandra Galetin
Published 2021-05-01

A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations

by Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew‐Mei Huang, Amin Rostami‐Hodjegan, Aleksandra Galetin
Published 2020-06-01

Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions

by Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew‐Mei Huang, Amin Rostami‐Hodjegan, Aleksandra Galetin
Published 2020-05-01

Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug–Drug Interactions in Rats

by Nicola Melillo, Daniel Scotcher, J. Gerry Kenna, Claudia Green, Catherine D. G. Hines, Iina Laitinen, Paul D. Hockings, Kayode Ogungbenro, Ebony R. Gunwhy, Steven Sourbron, John C. Waterton, Gunnar Schuetz, Aleksandra Galetin
Published 2023-03-01