Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-IgResearch in context

by Ziyang Xu, Megan C. Wise, Hyeree Choi, Alfredo Perales-Puchalt, Ami Patel, Edgar Tello-Ruiz, Jacqueline D. Chu, Kar Muthumani, David B. Weiner
Published 2018-09-01

Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection

by Elizabeth M. Parzych, Sunita Gulati, Bo Zheng, Mamadou A. Bah, Sarah T. C. Elliott, Jacqueline D. Chu, Nancy Nowak, George W. Reed, Frank J. Beurskens, Janine Schuurman, Peter A. Rice, David B. Weiner, Sanjay Ram
Published 2021-04-01

Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model

by Nicholas J. Tursi, Sophia M. Reeder, Yevel Flores-Garcia, Mamadou A. Bah, Shamika Mathis-Torres, Berenice Salgado-Jimenez, Rianne Esquivel, Ziyang Xu, Jacqueline D. Chu, Laurent Humeau, Ami Patel, Fidel Zavala, David B. Weiner
Published 2022-08-01

DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2

by Elizabeth M. Parzych, Jianqiu Du, Ali R. Ali, Katherine Schultheis, Drew Frase, Trevor R. F. Smith, Jiayan Cui, Neethu Chokkalingam, Nicholas J. Tursi, Viviane M. Andrade, Bryce M. Warner, Ebony N. Gary, Yue Li, Jihae Choi, Jillian Eisenhauer, Igor Maricic, Abhijeet Kulkarni, Jacqueline D. Chu, Gabrielle Villafana, Kim Rosenthal, Kuishu Ren, Joseph R. Francica, Sarah K. Wootton, Pablo Tebas, Darwyn Kobasa, Kate E. Broderick, Jean D. Boyer, Mark T. Esser, Jesper Pallesen, Dan W. Kulp, Ami Patel, David B. Weiner
Published 2022-10-01